LOCI

作品数：242被引量：941H指数：11
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Genome-wide association study identifies novel loci associated with feed efficiency traits in Hu lambs
《Journal of Integrative Agriculture》2025年第4期1259-1269,共11页Deyin Zhang Xiaolong Li Fadi Li Xiaoxue Zhang Yuan Zhao Yukun Zhang Zongwu Ma Huibin Tian Xiuxiu Weng Weimin Wang 
supported by the National Key R&D Program of China(2021YFD1300901);the National Key R&D Young Scientists Project of China(2022YFD1302000);the Education Department of Gansu Province:Outstanding Postgraduate“Innovation Star”,China(2022CXZX-086);the Major Science and Technology Project of Gansu Province,China(22ZD6NC069)。
Feed efficiency(FE)is a crucial economic trait that significantly impacts profitability in intensive sheep production,and can be evaluated by the residual feed intake(RFI)and feed conversion ratio(FCR).However,the und...
关键词：sheep feed efficiency GWAS RE-SEQUENCING RFI FCR 
The Homology Growth for Finite Abelian Covers of Smooth Quasi-projective Varieties
《Chinese Annals of Mathematics,Series B》2025年第1期51-62,共12页Fenglin LI Yongqiang LIU 
supported by the National Key Research and Development Project(No.SQ2020YFA070080);the National Natural Science Foundation of China(No.12001511);the Project of Stable Support for Youth Team in Basic Research Field CAS(No.YSBR-001);the Project of Analysis and Geometry on Bundles of the Ministry of Science and Technology of China and the Fundamental Research Funds for the Central Universities。
Let X be a complex smooth quasi-projective variety with a fixed epimorphism ν:π_(1)(X)■H,where H is a finitely generated abelian group with rank H≥1.In this paper,the authors study the asymptotic behaviour of Bett...
关键词：Mahler measure Jump loci Orbifold map L^(2)-Betti number 
Improving neuroblastoma risk prediction through a polygenic risk score derived from genome-wide association study-identified loci
《Chinese Journal of Cancer Research》2025年第1期1-11,共11页Wenli Zhang Jinhong Zhu Mengzhen Zhang Jiaming Chang Jiabin Liu Liping Chen Xinxin Zhang Haiyan Wu Chunlei Zhou Jing He 
supported by grants from the National Natural Science Foundation of China(No.82173593,32300473);Guangzhou Science and Technology Project(No.2025A04J4537,2025A04J4696);Guangdong Basic and Applied Basic Research Foundation(No.2023A1515220053);Postdoctoral Science Foundation of Jiangsu Province(No.2021K524C).
Objective:Neuroblastoma is the most common extracranial solid tumor in children and has complex genetic underpinnings.Previous genome-wide association studies(GWASs)have identified many loci associated with neuroblast...
关键词：GWAS POLYMORPHISM NEUROBLASTOMA SUSCEPTIBILITY polygenic risk score 
Age-dependent genetic architectures of chicken body weight explored by multidimensional GWAS and molQTL analyses
《Journal of Genetics and Genomics》2024年第12期1423-1434,共12页Conghao Zhong Xiaochang Li Dailu Guan The ChickenGTEx Consortium Boxuan Zhang Xiqiong Wang Liang Qu Huaijun Zhou Lingzhao Fang Congjiao Sun Ning Yang 
supported by the National Key Research and Development Program of China(2022YFF1000204 and 2021YFD1300600);STI 2030-Major Projects(2023ZD04052);the Open Projects of Key Laboratory for Poultry Genetics and Breeding of Jiangsu Province(JQLAB-KF-202301);China Agriculture Research Systems(CARS-40);the 2115 Talent Development Program of China Agricultural University。
Chicken body weight(BW)is a critical trait in breeding.Although genetic variants associated with BW have been investigated by genome-wide association studies(GWAS),the contributions of causal variants and their molecu...
关键词：CHICKEN Body weight AGE-DEPENDENT Molecular quantitative loci GWAS FarmGTEx 
A programmable CRISPR/dCas9-based epigenetic editing system enabling loci-targeted histone citrullination and precise transcription regulation
《Journal of Genetics and Genomics》2024年第12期1485-1493,共9页Xiaoya Zhang Abhisek Bhattacharya Chunxiang Pu Yan Dai Jia Liu Lang Rao Chaoguang Tian 
funded by the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIP-CXRC-048)。
Histone citrullination,an important post-translational modification mediated by peptidyl arginine deiminases,is essential for many physiological processes and epigenetic regulation.However,the causal relationship betw...
关键词：HISTONE CITRULLINATION Epigenetic editor Peptidyl arginine deiminase dCas9 
Comparative study on the expression characteristics of transgenes inserted into the Gt(ROSA)26Sor and H11 loci in mice
《Acta Biochimica et Biophysica Sinica》2024年第11期1687-1698,共12页Zhilan Yu Jiahao Shi Jingyu Zhang Youbing Wu Ruling Shen Jian Fei 
This work was supported by the grants from the National Key R&D Program of China(No.2019YFA0905900);the Science and Technology Commission of Shanghai Municipality(No.18DZ2293500);the Shanghai Engineering Research Center for Model Organisms(No.19DZ2280500);the Science and Technology Commission of Shanghai Municipality(Nos.22140900102 and 201409001900);the Shanghai Laboratory Animal Research Center(No.2023NS01).
The Gt(ROSA)26Sor(ROSA26)and H11 loci are commonly used as safe harbors for the construction of targeted transgenic mice.However,it remains unclear whether these two loci have distinct effects on transgene expression....
关键词：transgenic mouse knockin Gt(ROSA)26Sor H11 gene expression 
Genome-wide association study dissecting drought resistance-associated loci based on physiological traits in common bean
《Journal of Integrative Agriculture》2024年第11期3657-3671,共15页Lei Wu Yujie Chang Lanfen Wang Shumin Wang Jing Wu 
supported by the National Key Research and Development Program of China(2019YFD1001300 and 2019YFD1001305);the Fundamental Research Funds for the Central Universities,China(SWUKQ22042);the China Agriculture Research System of MOF and MARA(CARS-08);the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences。
Genetic improvement of drought resistance is one of the main breeding goals for common bean,so molecular markers must be identified to facilitate drought resistance breeding.In this study,we evaluated the proline,treh...
关键词：common bean drought resistance GWAS physiological trait 
Genetic dissection and origin of pleiotropic loci underlying multilevel fiber quality traits in upland cotton(Gossypium hirsutum L.)被引量：1
《Journal of Integrative Agriculture》2024年第10期3250-3263,共14页Hongge Li Shurong Tang Zhen Peng Guoyong Fu Yinhua Jia Shoujun Wei Baojun Chen Muhammad Shahid Iqbal Shoupu He Xiongming Du 
supported by the National Key Research and Development Program of China(2022YFD1200300);the Central Plain Scholar Program,China(234000510004);the National Supercomputing Center in Zhengzhou,China。
Cotton fiber quality is a persistent concern that determines planting benefits and the quality of finished textile products.However,the limitations of measurement instruments have hindered the accurate evaluation of s...
关键词：upland cotton single fiber quality pleiotropic loci candidate genes locus origin 
Mining elite loci and candidate genes for root morphology-related traits at the seedling stage by genome-wide association studies in upland cotton(Gossypium hirsutum L.)被引量：1
《Journal of Integrative Agriculture》2024年第10期3406-3418,共13页Huaxiang Wu Xiaohui Song Muhammad Waqas-Amjid Chuan Chen Dayong Zhang Wangzhen Guo 
supported by the Jiangsu Natural Science Foundation,China(BK20231468);the Fundamental Research Funds for the Central Universities,China(ZJ24195012);the National Natural Science Foundation in China(31871668);the Jiangsu Key R&D Program,China(BE2022384);the Xinjiang Uygur Autonomous Region Science and Technology Support Program,China(2021E02003);the Jiangsu Collaborative Innovation Center for Modern Crop Production Project,China(No.10)。
Root system architecture plays an essential role in water and nutrient acquisition in plants,and it is significantly involved in plant adaptations to various environmental stresses.In this study,a panel of 242 cotton ...
关键词：cotton root-morphology traits quantitative trait loci candidate genes GWAS 
Simultaneous multiplex genome loci editing of Halomonas bluephagenesis using an engineered CRISPR-guided base editor
《Synthetic and Systems Biotechnology》2024年第3期586-593,共8页Yulin Zhang Yang Zheng Qiwen Hu Zhen Hu Jiyuan Sun Ping Cheng Xiancai Rao Xiao-Ran Jiang 
supported by the National Natural Science Foundation of China(Grant No.32171415);the Chongqing Talents Top Youth Talent Program(No.CQYC202105065).
Halomonas bluephagenesis TD serves as an exceptional chassis for next generation industrial biotechnology to produce various products.However,the simultaneous editing of multiple loci in H.bluephagenesis TD remains a ...
关键词：Base editor Gene editing Multiplex Halomonas bluephagenesis 
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