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作品数：242被引量：941H指数：11
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相关机构：东南大学浙江大学医学院附属邵逸夫医院华中科技大学中南财经政法大学更多>>
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Genome-wide association study identifies novel loci associated with feed efficiency traits in Hu lambs
《Journal of Integrative Agriculture》2025年第4期1259-1269,共11页Deyin Zhang Xiaolong Li Fadi Li Xiaoxue Zhang Yuan Zhao Yukun Zhang Zongwu Ma Huibin Tian Xiuxiu Weng Weimin Wang 
supported by the National Key R&D Program of China(2021YFD1300901);the National Key R&D Young Scientists Project of China(2022YFD1302000);the Education Department of Gansu Province:Outstanding Postgraduate“Innovation Star”,China(2022CXZX-086);the Major Science and Technology Project of Gansu Province,China(22ZD6NC069)。
Feed efficiency(FE)is a crucial economic trait that significantly impacts profitability in intensive sheep production,and can be evaluated by the residual feed intake(RFI)and feed conversion ratio(FCR).However,the und...
关键词：sheep feed efficiency GWAS RE-SEQUENCING RFI FCR 
Improving neuroblastoma risk prediction through a polygenic risk score derived from genome-wide association study-identified loci
《Chinese Journal of Cancer Research》2025年第1期1-11,共11页Wenli Zhang Jinhong Zhu Mengzhen Zhang Jiaming Chang Jiabin Liu Liping Chen Xinxin Zhang Haiyan Wu Chunlei Zhou Jing He 
supported by grants from the National Natural Science Foundation of China(No.82173593,32300473);Guangzhou Science and Technology Project(No.2025A04J4537,2025A04J4696);Guangdong Basic and Applied Basic Research Foundation(No.2023A1515220053);Postdoctoral Science Foundation of Jiangsu Province(No.2021K524C).
Objective:Neuroblastoma is the most common extracranial solid tumor in children and has complex genetic underpinnings.Previous genome-wide association studies(GWASs)have identified many loci associated with neuroblast...
关键词：GWAS POLYMORPHISM NEUROBLASTOMA SUSCEPTIBILITY polygenic risk score 
Age-dependent genetic architectures of chicken body weight explored by multidimensional GWAS and molQTL analyses
《Journal of Genetics and Genomics》2024年第12期1423-1434,共12页Conghao Zhong Xiaochang Li Dailu Guan The ChickenGTEx Consortium Boxuan Zhang Xiqiong Wang Liang Qu Huaijun Zhou Lingzhao Fang Congjiao Sun Ning Yang 
supported by the National Key Research and Development Program of China(2022YFF1000204 and 2021YFD1300600);STI 2030-Major Projects(2023ZD04052);the Open Projects of Key Laboratory for Poultry Genetics and Breeding of Jiangsu Province(JQLAB-KF-202301);China Agriculture Research Systems(CARS-40);the 2115 Talent Development Program of China Agricultural University。
Chicken body weight(BW)is a critical trait in breeding.Although genetic variants associated with BW have been investigated by genome-wide association studies(GWAS),the contributions of causal variants and their molecu...
关键词：CHICKEN Body weight AGE-DEPENDENT Molecular quantitative loci GWAS FarmGTEx 
Genome-wide association study dissecting drought resistance-associated loci based on physiological traits in common bean
《Journal of Integrative Agriculture》2024年第11期3657-3671,共15页Lei Wu Yujie Chang Lanfen Wang Shumin Wang Jing Wu 
supported by the National Key Research and Development Program of China(2019YFD1001300 and 2019YFD1001305);the Fundamental Research Funds for the Central Universities,China(SWUKQ22042);the China Agriculture Research System of MOF and MARA(CARS-08);the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences。
Genetic improvement of drought resistance is one of the main breeding goals for common bean,so molecular markers must be identified to facilitate drought resistance breeding.In this study,we evaluated the proline,treh...
关键词：common bean drought resistance GWAS physiological trait 
Genetic dissection and origin of pleiotropic loci underlying multilevel fiber quality traits in upland cotton(Gossypium hirsutum L.)被引量：1
《Journal of Integrative Agriculture》2024年第10期3250-3263,共14页Hongge Li Shurong Tang Zhen Peng Guoyong Fu Yinhua Jia Shoujun Wei Baojun Chen Muhammad Shahid Iqbal Shoupu He Xiongming Du 
supported by the National Key Research and Development Program of China(2022YFD1200300);the Central Plain Scholar Program,China(234000510004);the National Supercomputing Center in Zhengzhou,China。
Cotton fiber quality is a persistent concern that determines planting benefits and the quality of finished textile products.However,the limitations of measurement instruments have hindered the accurate evaluation of s...
关键词：upland cotton single fiber quality pleiotropic loci candidate genes locus origin 
Mining elite loci and candidate genes for root morphology-related traits at the seedling stage by genome-wide association studies in upland cotton(Gossypium hirsutum L.)被引量：1
《Journal of Integrative Agriculture》2024年第10期3406-3418,共13页Huaxiang Wu Xiaohui Song Muhammad Waqas-Amjid Chuan Chen Dayong Zhang Wangzhen Guo 
supported by the Jiangsu Natural Science Foundation,China(BK20231468);the Fundamental Research Funds for the Central Universities,China(ZJ24195012);the National Natural Science Foundation in China(31871668);the Jiangsu Key R&D Program,China(BE2022384);the Xinjiang Uygur Autonomous Region Science and Technology Support Program,China(2021E02003);the Jiangsu Collaborative Innovation Center for Modern Crop Production Project,China(No.10)。
Root system architecture plays an essential role in water and nutrient acquisition in plants,and it is significantly involved in plant adaptations to various environmental stresses.In this study,a panel of 242 cotton ...
关键词：cotton root-morphology traits quantitative trait loci candidate genes GWAS 
Simultaneous multiplex genome loci editing of Halomonas bluephagenesis using an engineered CRISPR-guided base editor
《Synthetic and Systems Biotechnology》2024年第3期586-593,共8页Yulin Zhang Yang Zheng Qiwen Hu Zhen Hu Jiyuan Sun Ping Cheng Xiancai Rao Xiao-Ran Jiang 
supported by the National Natural Science Foundation of China(Grant No.32171415);the Chongqing Talents Top Youth Talent Program(No.CQYC202105065).
Halomonas bluephagenesis TD serves as an exceptional chassis for next generation industrial biotechnology to produce various products.However,the simultaneous editing of multiple loci in H.bluephagenesis TD remains a ...
关键词：Base editor Gene editing Multiplex Halomonas bluephagenesis 
Genetic Polymorphisms of 22 Novel Autosomal Short Tandem Repeat Loci in Sierra Leone Population
《Journal of Forensic Science and Medicine》2024年第3期209-213,I0001-I0008,共13页Yi Liu Chudong Wang Dan Wen Weifeng Qu Hao Xing Hongtao Jia Ruyi Xu Xuan Tang Siqi Chen Jienan Li Guanlin Li Lagabaiyila Zha Yong Wang 
This work was supported by the Key Program of National Natural Science Foundation of China(NSFC)(grant number 82230064);the General Program of National Natural Science Foundation of China(NSFC)(grant number 82271928).
Background:Exploring and identifying novel alleles of noncombined DNAIndex System(CODIS)short tandem repeat(STR)loci in different ethnic groups is important for the establishment of forensic reference databases and st...
关键词：Genetic polymorphisms Microreader™23SP ID System short tandem repeat Sierra Leone 
GWASTool:A web pipeline for detecting SNP-phenotype associations被引量：1
《Fundamental Research》2024年第4期761-769,共9页Xin Wang Beibei Xin Maozu Guo Guoxian Yu Jun Wang 
the National Natural Science Foundation of China(62031003 and 62072380);Shandong Provincial Key Research and Development Program(2021CXGC010506).
The genome-wide association study(GWAS)aims to detect associations between individual single nucleotide polymorphisms(SNPs)or SNP interactions and phenotypes to decipher the genetic mechanism.Existing GWAS analysis to...
关键词：Genome-wideassociation studies SNP interactions Associated loci detection SNP visualization Web server 
A CRISPR/Cas9-based visual toolkit enabling multiplex integration at specific genomic loci in Aspergillus niger
《Synthetic and Systems Biotechnology》2024年第2期209-216,共8页Yangyang Li Cen Li Yishan Fu Quan Zhang Jianing Ma Jingwen Zhou Jianghua Li Guocheng Du Song Liu 
This work was financially supported by the National Key Research and Development Program of China(2019YFA0706900);the National Natural Science Foundation of China(No.32071474);the Postgraduate Research and Practice Innovation Program of Jiangsu Province(KYCX20_1821).
Aspergillus niger is a highly versatile fungal strain utilized in industrial production.The expression levels of recombinant genes in A.niger can be enhanced by increasing the copy number.Nevertheless,given the prolon...
关键词：Multiplex integration Aspergillus niger CRISPR-Cas9 homologous direct repair White colony 
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