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TMED10-mediated unconventional secretion of IL-33 regulates intestinal epithelium differentiation and homeostasis被引量：1
《Cell Research》2024年第3期258-261,共4页Yang Wang Meimei Huang Xiangyue Mu Wanlu Song Qing Guo Min Zhang Yuan Liu Ye-Guang Chen Liang Ge 
funded by Ministry of Science and Technology of the People's Republic of China (2021YFA0804802);the National Natural Science Foundation of China (32225013,31988101 (Y.-G.C.),92254302,32130023,32061143009);Beijing Natural Science Foundation (Q20028);Vanke Special Fund for Public Health and Health Discipline Development,Tsinghua University (2022Z82WKJ009);Ministry of Science and Technology of the People's Republic of China (2019YFA0508602);New Cornerstone Science Foundation (Xplorer Prize).
Dear Editor,Unconventional protein secretion(UcPS)refers to the release of non-signal peptide-containing secretory proteins independent of the ER–Golgi trafficking.1 Although two major pathways including vesicle-depe...
关键词：HOMEOSTASIS EPITHELIUM DETAILS 
Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis被引量：1
《Cell Research》2023年第7期546-561,共16页Zhe Lin Shuang Zhao Xuesong Li Zian Miao Jiawei Cao Yurong Chen Zhiguang Shi Jia Zhang Dongjin Wang Shaoliang Chen Liansheng Wang Aihua Gu Feng Chen Tao Yang Kangyun Sun Yi Han Liping Xie Hongshan Chen Yong Ji 
This work was supported by grants from the National Natural Science Foundation of China(82121001,82030013,91639204,82241211,81820108002,82270421,81970428,31771334,91649125,81900262,82100414,81800385,82270484),the National Key R&D Program of China(2019YFA0802704),and Jiangsu Provincial Natural Science Foundation(BK20190656).
Genetic information is generally transferred from RNA to protein according to the classic“Central Dogma”.Here,we made a striking discovery that post-translational modification of a protein specifically regulates the...
关键词：ADAR1 MEDIATED EDITING 
Correction:CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification
《Cell Research》2022年第12期1133-1133,共1页
The article“CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification”,written by Xin-Yuan Lyu,Yuan Deng,Xiao-Yan Huang,Zhen-Zhen Li,G...
关键词：CRISPR DNA SEPARATION 
CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification被引量：7
《Cell Research》2022年第11期969-981,共13页Xin-Yuan Lyu Yuan Deng Xiao-Yan Huang Zhen-Zhen Li Guo-Qing Fang Dong Yang Feng-Liu Wang Wang Kang En-Zhi Shen Chun-Qing Song 
support from the Research Center for Industries of the Future(RCIF)at Westlake University,the Westlake Education Foundation,the National Natural Science Foundation of China(92068103);Westlake Laboratory of Life Sciences.E.-Z.S.acknowledges support from the Westlake Education Foundation and the National Natural Science Foundation of China(32070628).
The dynamic three-dimensional structures of chromatin and extrachromosomal DNA molecules regulate fundamental cellular processes and beyond.However,the visualization of specific DNA sequences in live cells,especially ...
关键词：SEPARATION SEQUENCES phase 
Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice被引量：5
《Cell Research》2022年第7期699-702,共4页Xi Gu Xinde Hu Daqi Wang Zhijiao Xu Fang Wang Di Li Geng-lin Li Hui Yang Huawei Li Erwei Zuo Yilai Shu 
supported by grants from the National Key R&D Program of China(2020YFA0908201,2017YFA0103900);the National Natural Science Foundation of China(82171148,81822011,31922048,81830029,82171141,82000992);the Science and Technology Commission of Shanghai Municipality(21S11905100,21JC401000);Clinic Research Plan of SHDC(SHDC2020CR4083),"Shuguang Program Hsupported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission(20SG08),and the Agricultural Science and Technology Innovation Program(to E.Z.).
Dear Editor,Hearing loss is the most common sensory disorder in the world.Among cases of non-syndromic hearing loss,which account for 70%of all cases of genetic hearing loss,around 80%of cases arise from autosomal rec...
关键词：CRISPR/Cas9 directed HOMOLOGY 
Structural basis of ALMT1-mediated aluminum resistance in Arabidopsis被引量：6
《Cell Research》2022年第1期89-98,共10页Jiangqin Wang Xiafei Yu Zhong Jie Ding Xiaokang Zhang Yanping Luo Ximing Xu Yuan Xie Xiaoxiao Li Tian Yuan Shao Jian Zheng Wei Yang Jiangtao Guo 
supported in part by the Ministry of Science and Technology(2020YFA0908501 and 2018YFA0508100 to J.G.,2016YFA0501100 to X.Z.);the National Natural Science Foundation of China(31870724 to J.G.,82030108,31872796 and 81571127 to W.Y.,31730006 to S.J.Z.,and 31600606 to X.Z.);National Major Special Project on New Drug Innovation of China(2018ZX09711001-004-005 to W.Y.);Zhejiang Provincial Natural Science Foundation(LR19C050002 to J.G.,LR16H090001 to W.Y.);the Fundamental Research Funds for the Central Universities(2021FZZX001-28 to J.G.and S.J.Z.);supported by MOE Frontier Science Center for Brain Science&Brain-Machine Integration,Zhejiang University;supported by Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017);CAS Key Laboratory of Brain Connectome and Manipulation(2019DP173024).
The plant aluminum(Al)-activated malate transporter ALMT1 mediates the efflux of malate to chelate the Al in acidic soils and underlies the plant Al resistance.Here we present cryo-electron microscopy(cryo-EM)structur...
关键词：ARABIDOPSIS RESISTANCE ACIDIC 
Enhancing prime editing by Csy4-mediated processing of pegRNA被引量：14
《Cell Research》2021年第10期1134-1136,共3页Yao Liu Guang Yang Shuhong Huang Xiangyang Li Xin Wang Guanglei Li Tian Chi Yulin Chen Xingxu Huang Xiaolong Wang 
We thank members of Huang lab and Wang lab for helpful discussions. We thank Prof. Quanjiang Ji from ShanghaiTech University for constructive suggestions. We thank the Molecular and Cell Biology Core Facility (MCBCF) at the School of Life Science and Technology, ShanghaiTech University for providing technical support. This work is supported by the National Natural Science Foundation of China (31972526 and 31772571);as well as Local Grants (2020KW-028 and 2018KJXX-009). X.W. is a Tang Scholar at Northwest A&F University.
Dear Editor,The most advanced prime editor 3(PE3)system comprises the editor,a fusion protein of Cas9 H840A nickase and mutant reverse transcriptase(RTase)(hereafter termed NMRT),a prime editing guide RNA(pegRNA)and a...
关键词：EDITOR EDITING TEMPLATE 
Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells
《Cell Research》2021年第9期998-1010,共13页Junyu Wu Chunyan Wu Fan Xing Liu Cao Weijie Zeng Liping Guo Ping Li Yongheng Zhong Hualian Jiang Manhui Luo Guang Shi Lang Bu Yanxi Ji Panpan Hou Hong Peng Junjiu Huang Chunmei Li Deyin Guo 
The work is supported by the National Natural Science Foundation of China(81620108020 and 32041002 to D.G.,31800151 to J.W.,81803568 to FX);Guangdong Zhujiang Talents Program(to D.G.);Shenzhen Science and Technology Program(KQTD20180411143323605 and JSGG20200225150431472 to D.G.,JCYJ20170818162249554 to F,X.);National Ten-thousand Talents Program(to D.G.)。
Nucleic acid-based systems play important roles in antiviral defense,including CRISPR/Cas that adopts RNA-guided DNA cleavage to prevent DNA phage infection and RNA interference(RNAi)that employs RNA-guided RNA cleava...
关键词：ENDOGENOUS CLEAVAGE destroyed 
Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation被引量：1
《Cell Research》2021年第3期312-325,共14页Guanhua Bai Yu Wang Mingjie Zhang 
This work was supported by a grant from the Minister of Science and Technology of China(2019YFA0508402);a grant from Human Frontier Science Program(RGP0020/2019);grants from Research Grant Council of Hong Kong(A〇E-M09-12 and C6004-17G)to M.Z.M.Z.is a Kerry Holdings Professor of Science,a Croucher Foundation Senior Fellow,and a Senior Fellow of IAS at HKUST.
Inhibitory synapses are also known as symmetric synapses due to their lack of prominent postsynaptic densities(PSDs)under a conventional electron microscope(EM).Recent cryo-EM tomography studies indicated that inhibit...
关键词：structure. SEPARATION phase 
Structural basis for nucleosome-mediated inhibition of cGAS activity被引量：10
《Cell Research》2020年第12期1088-1097,共10页Duanfang Cao Xiaonan Han Xiaoyi Fan Rui-Ming Xu Xinzheng Zhang 
the National Key R&D Program of China(2017YFA0504700,2019YFA0508900);the Ministry of Science and Technology of China;the National Natural Science Foundation of China(31930069,31521002 and 31991162);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37040101,XDB37010101).X.Z.received scholarships from the'National Thousand(Young)Talents Program,from the Office of Global Experts Recruitment in China.D.C.is sponsored by the Youth Innovation Promotion Association at the Chinese Academy of Sciences(2018124).
Activation of cyclic GMP-AMP synthase(cGAS)through sensing cytosolic double stranded DNA(dsDNA)plays a pivotal role in innate immunity against exogenous infection as well as cellular regulation under stress.Aberrant a...
关键词：complex. ACTIVATION COMPLEXES 
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