supported by the National Natural Science Foundation of China,Nos. 82171076 (to XS) and U22A20311 (to XS), 82101168 (to TL);Shanghai Science and technology Innovation Action Plan,No. 23Y11901300 (to JS);Science and Technology Commission of Shanghai Municipality,No. 21ZR1451500 (to TL);Shanghai Pujiang Program,No. 22PJ1412200 (to BY)。
Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss. Ferroptosis has been demonstrated to be associated with retinal de...
Supported by the National Natural Science Foundation of China,No.81970454.
BACKGROUND ATP-binding cassette subfamily B member 4(ABCB4)deficiency is associated with cholestatic liver disease primarily because of missense mutations,and many variants remain unidentified.Here,we validate the pat...
supported by the Natural Science Foundation of China(Grant No.32172512);the Jiangsu Special Fund for Frontier Foundation Research of Carbon Peaking and Carbon Neutralization(Grant No.BK20220005);a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions。
5-Aminolevulinic acid(ALA)is a novel plant growth regulator that has shown outstanding capability to promote stomatal opening.Starch degradation,catalyzed byβ-amylase(EC3.2.1.2,BAM),plays an important role in stomata...
Supported by the National Natural Science Foundation of China,No.81960506;Science and Technology Fund Project of Guizhou Provincial Health Commission,No.gzwkj2022-299;Key Projects of Zunyi Science and Technology Fund,No.zunshikeheHZzi(2023)24 and No.zunshikeheHZzi(2024)9.
BACKGROUND Radiotherapy is widely employed in colorectal cancer(CRC)treatment,but the occurrence of radioresistance severely limits the clinical benefit to patients and significantly contributes to treatment failure a...
Supported by the Medical Science Research Project Plan of the Hebei Provincial Health Commission,No.20210027.
BACKGROUND The upregulation of serpin family B member 5(SERPINB5)has been linked to the progression of rectal cancer.However,the specific roles and underlying mechanisms of SERPINB5 in rectal cancer are not fully unde...
Supported by Research Fund for Academician Lin He New Medicine,No.JYHL2022FMS02.
BACKGROUND The pathophysiology of diabetic kidney disease(DKD)is complex.Interfering with the processes of pyroptosis and fibrosis is an effective strategy for slowing DKD progression.Previous studies have revealed th...
the National Natural Science Foundation of China,No.82074425;Natural Foundation of Hunan Province,No.2023JJ30364 and No.2023JJ30361;Hunan Provincial Key R&D Program,No.2023SK2057;Key Project of Hunan Provincial Administration of Traditional Chinese Medicine,No.A2023042.
BACKGROUND Ferroptosis is an iron-dependent programmed non-apoptotic cell death characterized by the accumulation of free iron ions and lipid peroxidation.It is associated with the inactivation of glutathione peroxida...