METABOLISM

作品数:1845被引量:5652H指数:32
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相关机构:沈阳药科大学中国科学院浙江大学清华大学更多>>
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History and progress of hypotheses and clinical trials for Alzheimer’s disease被引量:34
《Signal Transduction and Targeted Therapy》2019年第1期412-433,共22页Pei-Pei Liu Yi Xie Xiao-Yan Meng Jian-Sheng Kang 
We appreciate funding by the National Natural Science Foundation of China(Grant No.31171369);the National Basic Research Program(973 Program)(Nos 2011CB910903 and 2010CB912001);the Chinese Academy of Sciences(Hundred Talents Program and 2009OHTP10);the Joint Construction Project of Henan Province(No.2018020088 and No.2018020114),and the First Affiliated Hospital of Zhengzhou University.
Alzheimer’s disease(AD)is a neurodegenerative disease characterized by progressive memory loss along with neuropsychiatric symptoms and a decline in activities of daily life.Its main pathological features are cerebra...
关键词:ALZHEIMER METABOLISM CLINICAL 
Genome-wide identification of DNA-PKcs-associated RNAs by RIP-Seq
《Signal Transduction and Targeted Therapy》2019年第1期493-495,共3页Zhiquan Song Ying Xie Zongpei Guo Yang Han Hua Guan Xiaodan Liu Teng Ma Ping-kun Zhou 
This work was supported by grants from the National Key Basic Research Program(973 Program)of MOST,China(Grant No.2015CB910601);the National Natural Science Foundation of China(Grant Nos.31370843 and 31500681)to P.K;Zhou and the National Natural Science Foundation,China(Grant Nos.31570853 and 81602799)to T.Ma.
Dear Editor,The DNA-dependent protein kinase catalytic subunit(DNA-PKcs)forms a serine/threonine protein kinase complex with the Ku heterodimer(Ku70/Ku80)and plays an important role in the DNA damage response(DDR)and ...
关键词:GENOME METABOLISM damage 
Effects of spaceflight and simulated microgravity on microbial growth and secondary metabolism被引量:9
《Military Medical Research》2018年第4期335-349,共15页Bing Huang Dian-Geng Li Ying Huang Chang-Ting Liu 
supported by the China Manned Space Engineering Program(CMSE,921–2);the National Program on Key Basic Research Project(973 Program,No.2014CB744400);the General Financial Grant from the China Postdoctoral Science Foundation(No.2016 M602971)
Spaceflight and ground-based microgravity analog experiments have suggested that microgravity can affect microbial growth and metabolism. Although the effects of microgravity and its analogs on microorganisms have bee...
关键词:MICROBIAL growth SECONDARY METABOLISM SPACEFLIGHT MICROGRAVITY Simulated MICROGRAVITY MICROGRAVITY ANALOGS 
Effects of Huanglian Jiedu Decoction on Rat Gingivitis Induced by LPS
《Medicinal Plant》2018年第5期89-92,96,共5页Fangbo ZHANG Miao XU Yi ZHANG Defeng LI Hongjie WANG Haiyu ZHAO Baolin BIAN 
Supported by the Key Project of Chinese National Programs for Fundamental Research and Development(973 Program,2014CB543003);the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ10-018-09)
[Objectives] To evaluate the effects of Huanglian Jiedu Decoration( HLJD) on the treatment of rat gingivitis with excess internal heat through injecting lipopolysaccharide( LPS) in tooth-supporting tissues. [Methods]G...
关键词:Huanglian Jiedu DECORATION I EXCESS internal heat GINGIVITIS GLYCOLYSIS Energy METABOLISM OXIDATIVE stress 
Leucine modulates the IPEC-J2 cell proteome associated with cell proliferation, metabolism and phagocytosis被引量:3
《Animal Nutrition》2018年第3期316-321,共6页Xiangbing Mao Man Ren Daiwen Chen Bing Yu Lianqiang Che Jun He Junqiu Luo Yuheng Luo Jianping Wang Hui Sun 
financially supported by the grant from the National Basic Research Program(973 Program)of China(2013CB127306);the grant from National Natural Science Foundation of China(31201812);the earmarked fund for the China Agriculture Research System(CARS-35)
Leucine can affect intestinal protein expressions, and improve mucosal immune function. However, little study has been conducted to determine the change of protein component by leucine treatment in intestine epithelia...
关键词:LEUCINE IPEC-J2 cells PROTEOME PHAGOCYTOSIS Cell proliferation Apoptosis and metabolism 
Enhancement of Simultaneous Xylose and Glucose Utilization by Regulating ZWF1 and PGI1 in Saccharomyces Cerevisiae被引量:1
《Transactions of Tianjin University》2017年第3期201-210,共10页Gaogang Liu Bingzhi Li Chun Li Yingjin Yuan 
supported by the National Basic Research Program of China(‘‘973’’Program,No.2013CB733601);the National High Technology Research and Development Program of China(‘‘863’’Program,No.2012AA02A701);the National Natural Science Foundation of China(No.21390203);the Tianjin Municipal Science and Technology Committee(No.13RCGFSY19800)
Xylose utilization is one of the key issues in lignocellulose bioconversion. Because of glucose repression, in most engineered yeast with heterogeneous xylose metabolic pathway, xylose is not consumed until glucose is...
关键词:METABOLISM XYLOSE YEAST 
Impact of hepatitis B virus infection on hepatic metabolic signaling pathway被引量:10
《World Journal of Gastroenterology》2016年第36期8161-8167,共7页Yi-Xian Shi Chen-Jie Huang Zheng-Gang Yang 
Supported by the National Natural Science Foundation of China,No.81270500;The State 12th 5-Year Plan S&T Projects of China,No.2012ZX10002007;The National Basic Research Program(973 Program)in China,No.2013CB531400
A growing body of epidemiologic research has demonstrated that metabolic derangement exists in patients with hepatitis B virus(HBV) infection, indicating that there are clinical associations between HBV infection and ...
关键词:HEPATITIS B virus infection Nucleic ACID METABOLISM METABOLIC derangement METABOLIC signaling pathway Glucose METABOLISM Lipid METABOLISM BILE ACID METABOLISM VITAMIN METABOLISM 
Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effect被引量:10
《Acta Pharmacologica Sinica》2016年第8期1013-1019,共7页Xi-sha CHEN Lan-ya LI Yi-di GUAN Jin-ming YANG Yan CHENG 
This work was supported by grants from the National Basic Research Program of China (973 Program, 2015CB910700) (Yan CHENG) and the National Natural Science Foundation of China (81422051, 81472593, and 31401208) (Yan CHENG).
Tumor cells rely mainly on glycolysis for energy production even in the presence of sufficient oxygen, a phenomenon termed the Warburg effect, which is the most outstanding characteristic of energy metabolism in cance...
关键词:glycolysis cancer cells cancer cells metabolism Warburg effect anticancer strategy 
An adaptive path selection model for WSN multipath routing inspired by metabolism behaviors被引量:8
《Science China(Information Sciences)》2015年第10期128-142,共15页GONG WeiBing YANG XiaoLong ZHANG Min LONG KePing 
supported by National Basic Research Program of China(973 Program)(Grant No.2012CB315905);National Natural Science Foundation of China(Grant Nos.60932005,61172048,61100184,61201128);National High-tech R&D Program of China(863 Program)(Grant No.2013AA01A209)
In multipath routing of wireless sensor network (WSN), greedy path selection is always prone to cause path oscillation (frequent path changes) between each couple of sensor and sink nodes. To alleviate the side ef...
关键词:WSN MULTIPATH path selection metabolism behaviors of Escherichia Coli AODV 
Effects of Radix Aconiti Lateralis Preparata and Rhizoma Zingiberis on Energy Metabolism and Expression of the Genes Related to Metabolism in Rats被引量:6
《Chinese Journal of Integrative Medicine》2012年第1期23-29,共7页于华芸 王世军 滕佳林 季旭明 吴智春 马清翠 付先军 
Supported by the National Basic Research Program of China (973 Program,No.2007CB512601)
Objective: To study the influence of Radix aconiti lateralis preparata and Rhizoma zingiberis, two species of Chinese medicinal herbs with hot property, on energy metabolism and gene expression spectrum, and to analy...
关键词:Radix aconiti lateralis preparata Rhizoma zingiberis hot property energy metabolism gene array 
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