MICRONEEDLES

作品数：81被引量：205H指数：9
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相关领域：医药卫生更多>>
相关机构：安徽医科大学更多>>
相关期刊：《BMEMat(BioMedical Engineering Materials)》《Frontiers of Materials Science》《Advances in Chemical Engineering and Science》《Microsystems & Nanoengineering》更多>>
相关基金：国家自然科学基金高等学校学科创新引智计划中国博士后科学基金泰国研究基金更多>>
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Traditional Chinese Medicine Integrated Multifunctional Responsive Core-Shell Microneedles for Dermatosis Treatment
《Research》2025年第1期569-577,共9页Xi Luan Xiaoxuan Zhang Qichen Luan Jingjing Gan Yu Wang Yuanjin Zhao 
supported by National Key Research and Development Program of China(2020YFA0908200);National Natural Science Foundation of China(T2225003);National Natural Science Foundation of China(52073060);National Natural Science Foundation of China(61927805);Nanjing Medical Science and Technique Development Foundation(ZKX21019);Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);Natural Science Foundation of Jiangsu Province(BK20180408);Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);Shenzhen Science and Technology Program(JCYJ20210324133214038).
Microneedles have demonstrated value in targeted treatment of dermatosis.Current investigation aims to enhance the functions and optimize substance delivery to improve therapeutic effects.Here,we present innovative sh...
关键词：SCLERODERMA light ph dual responsiveness treat sclerodermaby chinese herb drugs spatiotemporal sequential release 
Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment
《Research》2024年第1期139-147,共9页Xi Luan Xiaoxuan Zhang Min Nie Yuanjin Zhao 
the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(T2225003,52073060,and 61927805);the Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);the Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_2064).
Traditional Chinese medicine,such as Tripterygium wilfordii and Paeonia lactiflora,has potential values in treating systemic sclerosis(SSc)and other autoimmune diseases,while their toxic side effect elimination and pr...
关键词：NEEDLE PRECISE TEMPLATE 
Bee Sting-Inspired Inflammation-Responsive Microneedles for Periodontal Disease Treatment被引量：2
《Research》2023年第4期23-31,共9页Chuanhui Song Xiaoxuan Zhang Minhui Lu Yuanjin Zhao 
This work was supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060 and 61927805);the Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);the Project funded by the China Postdoctoral Science Foundation(2021-TQ0145);the Jiangsu Funding Program for Excellent Postdoctoral Talent(2022ZB690),the Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038)。
Periodontal lesions are common and frustrating diseases that impact life quality.Efforts in this aspect aim at developing local drug delivery systems with better efficacy and less toxicity.Herein,inspired by the sting...
关键词：NEEDLE SEPARATION bringing 
Flexible Monitoring,Diagnosis,and Therapy by Microneedles with Versatile Materials and Devices toward Multifunction Scope被引量：3
《Research》2023年第4期793-820,共28页Shuo Wang Mengmeng Zhao Yibo Yan Peng Li Wei Huang 
This work was supported by the National Natural Science Foundation of China(no.62005216);University Science and Technology Association Talent Promotion Program of Shaanxi(no.20200102);Basic Public Welfare Research Program of Zhejiang(LQ22F050013);Fundamental Research Funds for the Central Universities.
Microneedles(MNs)have drawn rising attention owing to their merits of convenience,noninvasiveness,flexible applicability,painless microchannels with boosted metabolism,and precisely tailored multifunction control.MNs ...
关键词：STRATUM sized enable 
Photothermal Nano-Vaccine Promoting Antigen Presentation and Dendritic Cells Infiltration for Enhanced Immunotherapy of Melanoma via Transdermal Microneedles Delivery
《Research》2023年第2期139-157,共19页Jiaojiao Zhu Ruimin Chang Benliang Wei Yao Fu Xiang Chen Hong Liu Wenhu Zhou 
This work was supported by National Natural Science Foundation of China(Nos.U1903125,31800979);Natural ScienceFoundationof HunanProvinceinChina(2021JJ20084,2021J20092);the Science and Technology Innovation Program of Hunan Province(2021RC3020,2020RC2010);This study was also supported by National Key Research and Development Program of China(2019YFA0111600 and 2019YFE0120800);the Natural Science Foundation of China for Outstanding Young Scholars(82022060);the Youth Talent Program of Hunan Province(2019RS2009);the Natural Science Foundation of Hunan Province for Outstanding Young Scholars(2019JJ30040);Innovation-Driven Project of Central South University(2020CX043);China Postdoctoral Science Foundation Funded Project(2021M693558,2022T150741).
Immunotherapy has demonstrated the potential to cure melanoma,while the current response rate is still unsatisfactory in clinics.Extensive evidence indicates the correlation between the eficacy and pre-existing T-cell...
关键词：MELANOMA Antigen VACCINE 
Christmas Tree-Shaped Microneedles as FOLFIRINOX Spatiotemporal Delivery System for Pancreatic Cancer Treatment
《Research》2023年第2期177-186,共10页Danqing Huang Xiao Fu Xiaoxuan Zhang Yuanjin Zhao 
This work was supported by the National Key Research and Development Program of China(grant number 2020YFA0908200);the National Natural Science Foundation of China(grant numbers 52073060,61927805);the Guangdong Basic and Applied Basic Research Foundation(grant number 2021B1515120054);the Shenzhen Fundamental Research Program(grant numbers JCYJ20190813152616459,JCYJ20210324133214038).
As an effective combination chemotherapy,FOLFIRINOX regimen(fluorouracil,leucovorin,irinotecan,and oxaliplatin)has shown definite antitumor eficacy for treating pancreatic cancer(PC)nowadays.However,the traditional sy...
关键词：FOLFIRI CHEMOTHERAPY Cancer 
Bioinspired Rotation Microneedles for Accurate Transdermal Positioning and Ultraminimal-Invasive Biomarker Detection with Mechanical Robustness
《Research》2022年第3期45-59,共15页Yilin Cai Shiyi Huang Zhinan Zhang Jiazheng Zhang Xingyue Zhu Xiaoxiang Chen Xianting Ding 
the State Key Laboratory of Mechanical System and Vibration(Grant No.MSVZD202108);Base for Interdisciplinary Innovative Talent Training.The authors thank all who provided direct technical help and indirect assistance for the study。
Microneedle permits transdermal biosensing and drug delivery with minor pain.However,accurate microneedle transdermal positioning with minimal skin deformation remains a significant technical challenge due to inhomoge...
关键词：ROTATION precise faster 
Smart Microneedles for Therapy and Diagnosis被引量：8
《Research》2020年第1期1295-1320,共26页Xiaoxuan Zhang Yuetong Wang Junjie Chi Yuanjin Zhao 
This work was supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060 and 61927805);the Natural Science Foundation of Jiangsu(BE2018707).
Microneedles represent a cutting-edge and idea-inspiring technology in biomedical engineering,which have attracted increasing attention of scientific researchers and medical staffs.Over the past decades,numerous great...
关键词：SMART ACCOMPLISHMENT enable 
Bioinspired Adhesive and Antibacterial Microneedles for Versatile Transdermal Drug Delivery被引量：19
《Research》2020年第1期562-570,共9页Xiaoxuan Zhang Guopu Chen Yunru Yu Lingyu Sun Yuanjin Zhao 
This work was supported by the National Natural Science Foundation of China(grants 61927805 and 51522302);the Natural Science Foundation of Jiangsu(Grant no.BE2018707);the Scientific Research Foundation of Nanjing University and Drum Tower Hospital.
Microneedles have attracted increasing interest among various medical fields due to their painless,noninvasive,and efficient way of drug delivery.However,practical applications of these microneedles in different epide...
关键词：NEEDLE base SUSTAINED 
Living Bacterial Microneedles for Fungal Infection Treatment被引量：5
《Research》2020年第1期446-454,共9页Fengyuan Wang Xiaoxuan Zhang Guopu Chen Yuanjin Zhao 
This work was supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060 and 61927805);the Natural Science Foundation of Jiangsu(BE2018707 and BK20190353).
Fungal infections are everlasting health challenges all over the world,bringing about great financial and medical burdens.Here,inspired by the natural competition law of beneficial bacteria against other microbes,we p...
关键词：INVASION bringing removed 
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