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MOLECULAR_MECHANISM: 作品数：506被引量：1424H指数：17; 导出分析报告; 相关作者：钱秋杰钟伯雄林荣呈李良璧许长成更多>>; 相关机构：西北农林科技大学中国科学技术大学中国科学院植物研究所北京大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金河北省自然科学基金更多>>

Elucidating the anti-obesity phytochemicals in Chenpi and their molecular mechanisms: 《Food Science and Human Wellness》2025年第4期1224-1238,共15页Jinhai Luo Weiqi Yan Zhi Chen Baojun Xu; supported by the Guangdong Provincial Key Laboratory IRADS(2022B1212010006,R0400001-22)。; Obesity has become a significant global public health issue.Previous studies have found that the Chenpi has the anti-obesity activity.However,the anti-obesity phytochemicals and their mechanisms are still unclear.This...; 关键词：Chenpi PHYTOCHEMICALS OBESITY Network pharmacology Molecular mechanism Signaling pathway

Inquiry of modulatory role of sea buckthorn fruit oil on dyslipidemia and gut microbiota in hyperlipidemia mice: 《Food Science and Human Wellness》2025年第4期1529-1537,共9页Pimiao Huang Zehua Chen Wenzi Li Aihua Su Chun Cui; supported by the National Natural Science Foundation of China(31201416);Programme of Introducing Talents of Discipline to Universities(B17018)。; Hyperlipidemia constitutes a critical factor in the pathogenesis of vascular disease and gut microbiota dysbiosis.This study aims to investigate the role of sea buckthorn fruit oil(SBFO)in ameliorating hyperlipidemia,...; 关键词：Sea buckthorn fruit oil HYPERLIPIDEMIA Gut microbiota Molecular mechanism

Molecular mechanism of tumor-infiltrating immune cells regulating endometrial carcinoma: 《Genes & Diseases》2025年第3期265-277,共13页Silu Ding Yingying Hao Yue Qi Heng Wei Jin Zhang Hui Li; Endometrial carcinoma(EC)is a prevalent gynecological cancer,and its interaction with the immune system is pivotal in cancer progression.This comprehensive review explores the molecular mechanisms involved in the regu...; 关键词：Clinical implication Endometrial carcinoma Immune checkpoint pathways Immune evasion strategies Tumor-infiltrating immune cells

Molecular Mechanism Behind the Capture of Fluorinated Gases by Metal–Organic Frameworks: 《Nano-Micro Letters》2025年第5期407-462,共56页Qian Wang Yong Hu Yifan Gu; funded by the National Key Research and Development Program of China(2022YFE0110500);National Natural Science Foundation of China(22376161,52373154,52103181);the Fundamental Research Funds for the Central Universities of China;the Interdisciplinary Project in Environmental Science and Engineering of Tongji University(2023-3-YB-02)。; Fluorinated gases(F-gases)play a vital role in the chemical industry and in the fields of air conditioning,refrigeration,health care,and organic synthesis.However,the direct emission of waste gases containing F-gases ...; 关键词：Fluorinated gas Metal–organic framework ADSORPTION SEPARATION Molecular interaction

Molecular mechanism of delayed development by interfering RNA targeting the phenylalanine ammonia lyase gene(pal1)in Pleurotus ostreatus: 《Journal of Integrative Agriculture》2025年第4期1477-1488,共12页Qi He Yuqing Jiang Chenyang Huang Lijiao Zhang Ludan Hou Fangjie Yao Mengran Zhao; supported by the National Key R&D Program of China(2022YFD1200600);the National Natural Science Foundation of China(32002110);the earmarked fund for China Agriculture Research System(CARS-20)。; Blocking the development of edible mushrooms will affect the production cycle and yield of fruiting bodies.Phenylalanine ammonia lyase(PAL,EC 4.3.1.24.)is an enzyme that catalyzes the deamination of phenylalanine to f...; 关键词：Pleurotus ostreatus phenylalanine ammonia lyase CATALASE DEVELOPMENT REGULATION

The Role of Linker Histone Mutation in Oncogenesis: Molecular Mechanism and Structural Impact: 《BIOCELL》2025年第4期519-538,共20页Gege Liu Houfang Zhang Yunhui Peng; supported by the National Natural Science Foundation of China(No.12205112);financially supported by self-determined research funds of CCNU from the colleges’basic research and operation of MOE(CCNU24JC012);supported by Natural Science Foundation of Wuhan(No.2024040801020302).; Nucleosomes play a vital role in chromatin organization and gene regulation,acting as key hubs that inter-act with various chromatin-associated factors through diverse binding mechanisms.Recent research has highlighte...; 关键词：Linker histone H1 EPIGENETICS histone cancer mutations chromatin structure NUCLEOSOME

Discovery and mechanism of anti-hypertensive effect of a novel tripeptide(SYP)from medicinal fungus Ganoderma lingzhi: 《Food Science and Human Wellness》2025年第2期509-524,共16页Qiang Wu Feijun Luo Jia Huang Ping Huang Yongnan Liu Xiaoling Wang Gaoqiang Liu; supported by the National Natural Science Foundation of China(32071673 and 32202573);the Program of Hunan Science and Technology Innovation Team(2021RC4063);the Natural Science Foundation of Hunan Province(2021JJ31151 and 2022JJ50028);the Key Scientific Research Project of Hunan Education Department(22A0538)。; Ganoderma lingzhi is a new species of the prize medicinal mushroom Ganoderma(Agaricomycetes).Using angiotensin I-converting enzyme(ACE)as a target,a tripeptide Ser-Tyr-Pro(SYP)was discovered with preponderant ACE inhi...; 关键词：Antihypertensive peptide Ganoderma lingzhi Gene microarray Molecular mechanism

Molecular Mechanism Study on the Expression of TF-MPs in Cervical Cancer Patients and Deep Venous Thrombosis: 《Journal of Clinical and Nursing Research》2025年第3期120-125,共6页Qingrong Hu Jin Li Kedan Liu; Correlation analysis between TF-MPs expression level and deep vein thrombosis in patients with cervical cancer(Project No.:2023-ZD-69)。; Objective:To explore the molecular mechanism of tissue factor-positive microparticles(TF-MPs)expression and deep venous thrombosis(DVT)in patients with cervical cancer.Methods:A total of 200 patients with cervical can...; 关键词：Cervical cancer TF-MPs Deep venous thrombosis Molecular mechanism

Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude: 《Science China(Life Sciences)》2025年第3期859-870,共12页Xing-Hui Hou Yong-Chao Xu Tianshu Sun Yan-Bo Gong Xin-Tong Li Guang-Teng Jin Yu-Tao Bian Yi-Ni Liu Juan Jiang Xiao-Min Niu Hongya Gu Ya-Long Guo; supported by the National Natural Science Foundation of China(31925004 and 32430008 to Y.-L.G.,and 32100175 to Y.-C.X.);CAS Project for Young Scientists in Basic Research(YSBR-078 to Y.-C.X.)。; To elucidate the process of adaptation,particularly the traits subject to natural selection and the molecular mechanisms underlying their natural variation,is one of the primary objectives of evolutionary biology.The ...; 关键词：ADAPTATION adaptive trait Arabidopsis thaliana high altitude molecular mechanism natural variation parallel evolution

Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model: 《Research》2025年第1期618-630,共13页Qian Wang Xiaonan Liu Hejian Zhang Huanyu Chu Chao Shi Lei Zhang Jie Bai Pi Liu Jing Li Xiaoxi Zhu Yuwan Liu Zhangxin Chen Rong Huang Hong Chang Tian Liu Zhenzhan Chang Jian Cheng Huifeng Jiang; funding from the National Key R&D Program of China(grant no.2019YFA0905700 and 2021YFC2103500);the National Natural Science Foundation of China(no.32371499);the China Postdoctoral Science Foundation(grant no.2019M661032);the National Natural Science Foundation of China(NSFC,grant nos.31901026 and 32171418);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(nos.TSBICIP-KJGG-002-02 and TSBICIP-CXRC-015);the Tianjin Science Fund for Distinguished Young Scholars(no.18JCJQJC48300).; Although cytochrome P450 enzymes are the most versatile biocatalysts in nature,there is insufficient comprehension of the molecular mechanism underlying their functional innovation process.Here,by combining ancestral ...; 关键词：cytochrome P progressive forward accumulationwe cytochrome p enzymes molecular mechanism ancestral sequence reconstructionreverse mutation assayand de novo design catalytic pocket functional innovation

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