This work was supported by grants from National Key Research and Development Program of China(2018YFA0108000);National Natural Science Foundation of China(31820103006,31630032,and 32070971);Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);ZJ Lab,and Shanghai Center for Brain Science and Brain-Inspired Technology.We thank Dr.John L.Rubenstein for critical reading of the manuscript.
Human cortical radial glial cells are primary neural stem cells that give rise to cortical glutaminergic projection pyramidal neurons, glial cells (oligodendrocytes and astrocytes) and olfactory bulb GABAergic interne...
supported by the People’s Liberation Army Fund for Special Projects of Medical Sciences, No. 06G114
This study aimed to identify the optimal neural progenitor cell transplantation time for spinal cord injury in rats via the subarachnoid space. Cultured neural progenitor cells from 14-day embryonic rats, constitutive...
Background Endothelial dysfunction is thought to be critical events in the pathogenesis of Alzheimer's disease (AD).Endothelial progenitor cells (EPCs) have provided insight into maintaining and repairing endothe...
Project supported by Science and Technology Foundation of Zhejiang Province(№021107613);Health Science Studying Foundation of Zhejiang Province(№2003A043).
Aim: To investigate whether aspirin has an influence on endothelial progenitor cells (EPC). Methods: Total mononuclear cells (MNC) were isolated from peripheral blood by Ficoll density gradient centrifugation, t...
supported by the National Natural Science Foundation of China,No.81070614;the Key Project of the Natural Science Foundation of Hubei Province of China,No.2008CDA044;the Natural Science Foundation of Hubei University of Medicine,No.2011QDZR-2
In the present study, we investigated the dynamic expression of fibroblast growth factor 8 and Sonic Hedgehog signaling pathway related factors in the process of in vitro hippocampal neural stem/progenitor cell differ...
Aim: The recruitment of endothelial progenitor cells (EPC) to ischemia has recently been suggested as an important mechanism of tissue repair. Although tissue ischemia can facilitate EPC mobilization, recruitment, ...
This work was supported by grants from the National Basic Research Program of China (No.973, 2001CB510104), National Natural Science Foundation of China (No. 30460141), and Program for New Century Excellent Talents in University (2005).
Background The existence of neurogenesis in the hippocampus of adult nonhuman primates has been confirmed in recent years, however, the biological properties of adult neural stem cells or neural progenitor cells (NPC...
the National Natural Science Foundation of China,No.30671041;the National Basic Research Program of China(973 Program),No. 2005CB623902
BACKGROUND: Studies of several animal models of central nervous system diseases have shown that neural progenitor cells (NPCs) can migrate to injured tissues. Stromal cell-derived factor 1 alpha (SDF-la), and its...
supported by NIH-NEI grants to DRH(R01-EY018417,R01-EY024519);the Center for Zebrafish Research,University of Notre Dame,USA
Sensing and responding to our environment requires functional neurons that act in concert. Neuronal cell loss resulting from degenerative diseases cannot be replaced in humans, causing a functional impairment to integ...
supported by the National Natural Science Foundation of China(No.82003403(Jianping Zhao),No.81974077,and No.82170633(Qian Chen)).
Schistosoma infection is one of the major causes of liver fibrosis.Emerging roles of hepatic progenitor cells(HPCs)in the pathogenesis of liver fibrosis have been identified.Nevertheless,the precise mechanism underlyi...