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TSP-1 promotes glomerular mesangial cell proliferation and extracellular matrix secretion in Thy-1 nephritis rats被引量：2
《The Journal of Biomedical Research》2011年第6期402-410,共9页Wen Qiu Yan Li Jianbo Zhou Chenhui Zhao Jing Zhang Kai Shan Dan Zha Yingwei Wang 
supported by grants from National Natural Science Foundations of China (No. 31000396, and No.81072402);grants from Natural Science Foundations of Jiangsu Province in China (No. BK2009417, No. 10KJB310006, and No. 09hx43)
The proliferation of glomerular mesangial cells （GMC） and secretion of the extracellular matrix （ECM） in rat with Thy-1 nephritis （Thy-lN） resembling human mesangioproliferative glomerulonephritis have been expl...
关键词：Thy-1 nephritis glomerular mesangial cells （GMCs） PROLIFERATION extracellular matrix thrombospondin-1 （ TSP-1） 
Combination of Quercetin, Hirudin and Cinnamaldehyde Promotes Schwann Cell Differentiation and Myelination against High Glucose by Inhibiting ERK Signaling Pathway被引量：2
《Chinese Journal of Integrative Medicine》2020年第8期591-598,共8页LIU Di LIANG Xiao-chun SUN Ying WU Ya-nan ZHANG Hong 
Supported by the National Natural Science Foundation of China(No.81473639);the Youth Scientific Research Foundation of Peking Union Medical College(No.33320140118)。
Objective:To investigate the therapeutic and synergistic effects of QHC(combination of quercetin(Q),hirudin(H)and cinnamaldehyd(C))on Schwann cell differentiation and myelination against high glucose(HG)induced injury...
关键词：diabetic peripheral neuropathy extracellular signal-regulated kinase pathway Schwann cells MYELINATION Chinese medicine synergistic effect 
Targeting UDP-α-D-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth被引量：1
《Genes & Diseases》2022年第3期717-730,共14页Daqian Zhan Fatih Yalcin Ding Ma Yi Fu Shuang Wei Bachchu Lal Yunqing Li Omar Dzaye John Laterra Mingyao Ying Hernando Lopez-Bertoni Shuli Xia 
This work was supported by grants from NIH R01NS091165(S.X.),R01 NS099460(M Ying),R01 NS096754(J Laterra),and R01 NS076759(J Laterra)。
Glioblastoma(GBM,WHO grade IV glioma)is the most common and lethal malignant brain tumor in aduts with a dismal prognosis.The extracellular matrix(ECM)supports GBM progression by promoting tumor cell proliferation,mig...
关键词：4-MU Extracellular matrix(ECM) Glioblastoma(GBM) Hyaluronic acid(HA) PHAGOCYTOSIS T cells Tumor-associated microglia/macrophages(TAMs) UGDH 
The roles of extracellular vesicles released by mechanically stimulated osteocytes in regulating osteoblast and osteoclast functions
《Mechanobiology in Medicine》2024年第2期71-78,共8页Yumei Chen Runze Zhao Li Yang X.Edward Guo 
Bone adapts to mechanical loading by changing its shape and mass.Osteocytes,as major mechanosensors,are critical for bone modeling/remodeling in response to mechanical stimuli.Intracellular calcium oscillation is one ...
关键词：OCY454 OSTEOCYTE MECHANOTRANSDUCTION Fluid flow Extracellular vesicles 
Decellularized extracellular matrix particle-based biomaterials for cartilage repair applications被引量：2
《Journal of Materials Science & Technology》2023年第29期194-203,共10页Peng Guo Nan Jiang Carina Mini Gregor Miklosic Songsong Zhu Andrea J.Vernengo Matteo D’Este Sibylle Grad Mauro Alini Zhen Li 
AO Foundation and AOSpine Inter-national.Peng Guo and Nan Jiang were funded by Sino Swiss Sci-ence and Technology Cooperation Program(Nos.EG-CN_01-032019 and EG-CN_04-042018);China Scholarship Council.MD and GM gratefully acknowledge funding from the Swiss National Sci-ence Foundation(SNSF,No.310030E_189310).
Cartilage Decellularized ExtraCellular Matrix(dECM)materials have shown promising cartilage regenera-tion capacity due to their chondrogenic bioactivity.However,the limited retention of ECM components and the reduced ...
关键词：Cartilage tissue engineering Decellularized extracellular matrix Proteoglycan integrity Biomimetic hydrogels Biomaterial Bioink 
Intraoperative bioprinting of human adipose-derived stem cells and extra-cellular matrix induces hair follicle-like downgrowths and adipose tissue formation during full-thickness craniomaxillofacial skin reconstruction
《Bioactive Materials》2024年第3期114-128,共15页Youngnam Kang Miji Yeo Irem Deniz Derman Dino JRavnic Yogendra Pratap Singh Mecit Altan Alioglu Yang Wu Jasson Makkar Ryan R.Driskell Ibrahim T.Ozbolat 
supported by National Institutes of Health Award R01DE028614,R56HL157190,R21AR082668,and R01AR078743,and 2236 CoCirculation2 of TUBITAK award 121C359.
Craniomaxillofacial(CMF)reconstruction is a challenging clinical dilemma.It often necessitates skin replacement in the form of autologous graft or flap surgery,which differ from one another based on hypodermal/dermal ...
关键词：Intraoperative bioprinting Adipose-derived extracellular matrix Adipose-derived stem cells Skin tissue engineering 
Identification of neutrophil extracellular trap-driven gastric cancer heterogeneity and C5AR1 as a therapeutic target被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第4期538-550,共13页Jing Zhao Xiangyu Li Liming Li Beibei Chen Weifeng Xu Yunduan He Xiaobing Chen 
supported by the grants from the Science and Technique Foundation of Henan Province(No.212102310778);the Medical Science and Technique Foundation of Henan Province(No.LHGJ20210201);the Henan Medical Science and Technology Research Program Joint Construction Project(No.LHGJ20220409).
Neutrophil extracellular traps(NETs)are implicated in gastric cancer(GC)growth,metastatic dissemination,cancerassociated thrombosis,etc.This work is conducted to elucidate the heterogeneity of NETs in GC.The transcrip...
关键词：neutrophil extracellular trap gastric cancer HETEROGENEITY personalized therapy C5AR1 treatment target 
High throughput and rapid isolation of extracellular vesicles and exosomes with purity using size exclusion liquid chromatography
《Bioactive Materials》2024年第10期683-695,共13页Kshipra S.Kapoor Kristen Harris Kent A.Arian Lihua Ma Beatriz Schueng Zancanela Kaira A.Church Kathleen M.McAndrews Raghu Kalluri 
supported by NCI R35CA263815.KAC is supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Numbers TL1TR003169 and UL1TR003167;The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health;We are grateful to Dr.Wenhua Guo for training KSK on cryogenic electron microscopy and Michelle Kirtley for assistance with serum samples.LM is thankful to the Shared Equipment Authority at Rice University for the support.Graphical figures in this work were created using BioRender.
Extracellular vesicles(EVs)have emerged as potential biomarkers for diagnosing a range of diseases without invasive procedures.Extracellular vesicles also offer advantages compared to synthetic vesicles for delivery o...
关键词：Extracellular vesicles Size exclusion-fast performance liquid CHROMATOGRAPHY Isolation methods 
Increasing plant species diversity aggravates microbial phosphorus limitation but alleviates microbial carbon limitation in a subtropical forest
《Journal of Plant Ecology》2024年第6期376-389,共14页Kun Gao Hu Du Zihong Zhu Yuantian Fang Dejun Li 
National Natural Science Foundation of China(U21A2007).
The relative limitation of microbes by soil organic carbon(SOC),nitrogen(N)and phosphorus(P)is linked with soil microbial activities,so how change of plant species diversity(PSD)affects microbial resource limitation w...
关键词：microbial carbon limitation microbial phosphorus limitation plant species diversity extracellular enzymatic stoichiometry soil nutrient availability 
Extracellular vesicles based electrochemical biosensors for detection of cancer cells:A review被引量：1
《Chinese Chemical Letters》2020年第7期1737-1745,共9页Hui Xie Kaili Di Rongrong Huang Adeel Khan Yanyan Xia Hongpan Xu Chang Liu Tingting Tan Xinyu Tian Han Shen Nongyue He Zhiyang Li 
the National Natural Science Foundation of China(Nos.61971216 and 61527806);National Key Research and Development Program of China(No.2017YFA0205301);the Jiangsu Province Medical Talent(No.ZDRCA2016065);the Key Research and Development Project of Jiangsu Province(No.BE2019603);the Health Care for Cadres Research Fund ofjiangsu Province(No.BJ16003);High-level Health Talent Project of Jiangsu Province(No.LGY2019001)。
Extracellular vesicles(EVs)derived from cancer cells are considered as ideal biomarker for liquid biopsy in cancer diagnosis,and are stable and abundant.Electrochemical methods for the detection of EVs are prefe rred ...
关键词：Cancerous Extracellular vesicles ELECTROCHEMICAL Biosensors DETECTION 
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