国家重点基础研究发展计划(2007CB948102)

作品数:112被引量:646H指数:13
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相关作者:姚元庆尹国武王珺闵保华朱晓明更多>>
相关机构:中国人民解放军总医院第四军医大学唐都医院中国人民解放军第一军医大学香港大学更多>>
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Phosphatidylcholine deficiency increases ferroptosis susceptibility in the Caenorhabditis elegans germline被引量:1
《Journal of Genetics and Genomics》2023年第5期318-329,共12页Jinglin Zhu Wei Meng Sin Man Lam Guanghou Shui Xun Huang 
supported by the National Natural Science Foundation of China and the Ministry of Science and Technology of China (32230044, 91954207, and 2018YFA0506902)
Ferroptosis,a regulated and iron-dependent form of cell death characterized by peroxidation of membrane phospholipids,has tremendous potential for the therapy of human diseases.The causal link between phospholipid hom...
关键词:PHOSPHATIDYLCHOLINE Ferroptosis SPIN-4 STERILITY LYSOSOME 
Abnormal magnetoresistance effect in the Nb/Si superconductor–semiconductor heterojunction
《Chinese Physics B》2023年第3期484-490,共7页胡志伟 邱祥冈 
the National Natural Science Foundation of China and the Ministry of Science and Technology of China.
Ultrathin superconducting Nb films of about 8 nm thick have been deposited on heavily doped Si substrates through DC magnetron sputtering and then the high-quality Nb/Si superconductor–semiconductor heterojunctions h...
关键词:SUPERCONDUCTOR MAGNETORESISTANCE HETEROJUNCTION 
Emerging roles of ILC2s in antitumor immunity
《Cellular & Molecular Immunology》2022年第11期1311-1313,共3页Zhao Li Hanxiao Sun Zhitao Gua Ju Qiu 
This work was supported by grants 2020YFA0509103 and 2019YFA0802502 to JQ from the Ministry of Science and Technology of China,grants 32022027 and 31970860 to JQ from the National Natural Science Foundation of China and grants 22ZR1481800 and 20ZR1466900 to JQ from Shanghai Science and Technology Committee(STCSM).
Group 2 innate lymphoid cells(ILC2s)are a subset of ILCs that lack T and B-cell antigen receptors[1].ILC2s share similarities with CD4+T helper 2 cells(Th2)in transcription factor GATA3 expression and signature cytoki...
关键词:ILC2s GATA3 IMMUNITY 
Significance and methodology:Preprocessing the big data for machine learning on TBM performance被引量:10
《Underground Space》2022年第4期680-701,共22页Hao-Han Xiao Wen-Kun Yang Jing Hu Yun-Pei Zhang Liu-Jie Jing Zu-Yu Chen 
support from the National Program on Key Basic Research Project(973 Program,No.2015CB058100)of China and China Railway Engineering Equipment Group Corporation;supported by the Key Research Project of China Institute of Water Resources and Hydropower Research Limited(Grant Nos.HTGE0203A03201900000,HTGE0203A20202000000);Natural Science Foundation of Shaanxi Province(Grant Nos.2019JLZ-13,2019JLP-23).
This paper addresses the significance of preprocessing big data collected during a tunnel boring machine(TBM)excavation before it is used for machine learning on various TBM performance predictions.The research work i...
关键词:TBM Big data Data processing Anomaly classification Machine learning 
Markers and Genetic Mechanisms of Primary and Epigenetic Oxidation of an Aeolian Depositional System of the Luohandong Formation,Ordos Basin被引量:4
《Journal of Earth Science》2022年第2期358-372,共15页Yao Xiang Yangquan Jiao Liqun Wu Hui Rong Fan Zhang 
supported by the National Key Research and Development Program of China (No.2018YFC0604202)from the Ministry of Science and Technology of China and the International Geosciences Program (No.IGCP675)
Uranium exploration breakthrough was extremely rare in an aeolian depositional system.In order to know the complicate characteristics of oxidation associated closely with uranium mineralization in the aeolian depositi...
关键词:Ordos Basin aeolian depositional system primary oxidation epigenetic oxidation sandstone-type uranium exploration ore deoposit geology 
Surgical left atrial appendage occlusion in patients with atrial fibrillation undergoing mechanical heart valve replacement
《Chinese Medical Journal》2020年第16期1891-1899,共9页Ye Zheng Chen-Fei Rao Si-Peng Chen Li He Jian-Feng Hou Zhe Zheng 
Supported by the grants from the Ministry of Science and Technology of China and the Prevention and Control Project of Major Chronic Non-infection Disease during the 13th 5-year plan period(No:2016YFC1302000);the Beijing Municipal Science and Technology Commission(D171100002917001).
Background:Surgical left atrial appendage occlusion(SLAAO)may be associated with a lower risk of thromboembolism in patientswith atrial fibrillation undergoing cardiac surgery.However,evidence regarding the effectiven...
关键词:Atrial fibrillation Heart valve prosthesis implantation Propensity score 
Liquid-liquid phase separation in biology: mechanisms,physiological functions and human diseases被引量:27
《Science China(Life Sciences)》2020年第7期953-985,共33页Hong Zhang Xiong Ji Pilong Li Cong Liu Jizhong Lou Zheng Wang Wenyu Wen Yue Xiao Mingjie Zhang Xueliang Zhu 
supported by grants from the Beijing Municipal Science and Technology Committee (Z181100001318003);the National Natural Science Foundation of China (31421002, 31561143001,31630048, and 31790403);the National Natural Science Foundation of China (91853113 and 31872716);the National Natural Science Foundation of China (11672317);the National Natural Science Foundation of China (31871394 and 31670730);supported by grants from the National Natural Science Foundation of China (31420103916 and 31991192);the Ministry of Science and Technology of China (2017YFA0503401);supported by grants from the Ministry of Science and Technology of China (2019YFA0707000);supported by grants from the Ministry of Science and Technology of China (2019YFA0508401);the Strategic Priority Research Program of the Chinese Academy of Sciences (CAS) (XDB19000000);the Key Research Program of Frontier Sciences, CAS (QYZDY-SSW-SMC006);supported by funds from the Ministry of Science and Technology of China and the National Natural Science Foundation of China (2017YFA0506600 and 31871309);supported by funds from the Ministry of Science and Technology of China and the National Natural Science Foundation of China (2019YFA0508403 and 31871443);supported by grants from the Ministry of Science and Technology of China (2016YFA0501902);the Science and Technology Commission of Shanghai Municipality (18JC1420500);the Shanghai Municipal Science and Technology Major Project (2019SHZDZX02);the Shanghai Municipal Science and Technology Major Project (2018SHZDZX01);CAS (XDB19020102);supported by grants from RGC of Hong Kong (AoE-M09-12 and C6004-17G);National Key R&D Program of China (2016YFA0501903 and 2019YFA0508402)。
Cells are compartmentalized by numerous membrane-enclosed organelles and membraneless compartments to ensure that a wide variety of cellular activities occur in a spatially and temporally controlled manner. The molecu...
关键词:phase separation phase transition TRANSCRIPTION asymmetric division postsynaptic density AUTOPHAGY 
The effect of monosaccharides on self-assembly of benzenetricarboxamides
《Chinese Chemical Letters》2019年第3期587-591,共5页Jue Wang Wenjing Qi Guosong Chen 
The Ministry of Science and Technology of China and the National Natural Science Foundation of China(Nos.91527305 and 51322306)are acknowledged for their financial support
The interaction between monosaccharides exhibits an important role in the assembly of monosaccharide-containing molecules. In this work, three common monosaccharides, glucose, galactose and mannose, are employed to in...
关键词:MONOSACCHARIDE SELF-ASSEMBLY Benzenetricarboxamide DYNAMIC LIGHT scatting (DLS) Depolarized DYNAMIC LIGHT scatting (DDLS) 
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis被引量:68
《Cell Research》2018年第12期1171-1185,共15页Bo Zhou Jia-yuan Zhang Xian-shuo Liu Hang-zi Chen Yuan-li Ai Kang Cheng Ru-yue Sun Dawang Zhou Jiahuai Han Qiao Wu 
the National Natural Science Foundation of China and the Ministry of Science and Technology of China(31230019,2014CBg10602,31822013,2017YFA0504502,81472425);the Program of Introducing Talents of Discipline to Universities(111 Project,B12001).
Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and to participate in different modes of cell death,such as ferroptosis,apoptosis and necroptosis. However,whether iron-elevat...
关键词:Tom20 SENSES iron-activated ROS signaling PROMOTE MELANOMA CELL PYROPTOSIS 
Formation process of akaganeite in the simulated wet-dry cycles atmospheric environment被引量:3
《Journal of Materials Science & Technology》2018年第8期1387-1396,共10页Haigang Xiao Wei Ye Xiaoping Song Yuantai Ma Ying Li 
financially supported by the National Natural Science Foundation of China under the contract Nos.51301182 and 51671198;the National Basic Research Program of China and Ministry of Science and Technology China under the contract No.2014CB643303
In order to clarify the formation mechanism and conditions for akaganeite in long-term exposure, the influence of the former corrosion results on akaganeite formation was investigated by simulated experi- ments in lab...
关键词:Carbon steel Atmospheric corrosion Corrosion products Chloride ions 
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