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国家自然科学基金(11232010): 作品数：14被引量：42H指数：4; 导出分析报告; 相关作者：齐颖新韩悦包晗姜宗来龚晓波更多>>; 相关机构：上海交通大学更多>>; 相关期刊：《National Science Review》《医用生物力学》《Computer Modeling in Engineering & Sciences》《Molecular & Cellular Biomechanics》更多>>; 相关主题：力学生物学低切应力血管平滑肌细胞平滑肌细胞增殖VASCULAR更多>>; 相关领域：医药卫生一般工业技术金属学及工艺理学更多>>

Numerical study of biomechanical characteristics of plaque rupture at stenosed carotid bifurcation:a stenosis mechanical property-specific guide for blood pressure control in daily activities: 《Acta Mechanica Sinica》2019年第6期1279-1289,共11页Shaoxiong Yang Qinghu Wang Weihao Shi Wencheng Guo Zonglai Jiang Xiaobo Gong; This work was supported by the National Key R&D Program of China(Grant 2017YFE0117100);the National Natural Science Foundation of China(Grants 11872040 and 11232010);the Outstanding Clinical Discipline Project of Shanghai Pudong(Grant PWYgy-2018-08);the Science and Technology Commission of Shanghai Municipality(Grant 18ZR1433900).; Acute stress concentration plays an important role in plaque rupture and may cause stroke or myocardial infarction.Quantitative evaluation of the relation between in vivo plaque stress and variations in blood pressure...; 关键词：Stenosed carotid bifurcation In vivo stress Plaque rupture Risk stratification Blood pressure control

Oct-1 Mediates ACTH-Induced Proliferation of Vascular Smooth Muscle Cells被引量：3: 《Molecular & Cellular Biomechanics》2019年第3期199-210,共12页Qian Xiao Xia Tang Yuanxiu Chen Han Bao Lizhi Gao Xiaobo Gong Ping Zhang; supported by grants from the National Natural Science Foundation of China(Grant Nos.11372190 and 11232010)。; Adrenocorticotrophic hormone(ACTH),a 39-amino acid peptide hormone,has been reported in the appreciation of the proliferation of vascular smooth muscle cells(VSMCs),however,the mechanism in molecular scale supporting ...; 关键词：Oct-1 PROLIFERATION ACTH VSMCS cyclic strech lamin B1

颈动脉分叉处血管粥样硬化斑块的体内应力分析被引量：13: 《医用生物力学》2019年第3期268-276,共9页王庆虎杨少雄许怡隽龚晓波; 国家自然科学基金项目(11372191,11232010); 目的探究颈动脉分叉处血管斑块的体内应力分布,为颈动脉分叉处血管斑块破裂行为的研究和诊断治疗方案的设计提供力学机理参考。方法基于人体颈动脉分叉血管的平均几何参数,建立三维颈动脉分叉血管及其斑块的几何模型,通过"热-结构"耦合...; 关键词：粥样硬化斑块颈动脉分叉残余应力弹性剪切应力流体壁面切应力斑块破裂

Characterizing the Mechanical Variations of Human Femoropopliteal Artery During Aging Process被引量：1: 《Molecular & Cellular Biomechanics》2019年第1期13-26,共14页Shaoxiong Yang Yingxin Qi Zonglai Jiang Xiaobo Gong; This work was supported by the National Natural Science Foundation of China(Grants 11872040,11232010).; Vascular diseases during aging process are closely correlated to the age-related changes of mechanical stimuli for resident cells.Characterizing the variations of mechanical environments in vessel walls with advancing...; 关键词：Femoropopliteal artery aging mechanical stress and strain wall stiffness vascular mechanobiology

A prediction of in vivo mechanical stresses in blood vessels using thermal expansion method and its application to hypertension and vascular stenosis被引量：7: 《Acta Mechanica Sinica》2018年第6期1156-1166,共11页Shaoxiong Yang Lucy T.Zhang Cheng Hua Yunqiao Liu Jingdong Tang Xiaobo Gong Zonglai Jiang; The authors would like to thank Prof.Shu Takagi and Prof.Huaxiong Huang for their instructive comments.The authors would also like to acknowledge Jianda Yang for assisting with FEM simulations.This work was supported by the National Natural Science Foundation of China(Grants 11372191,11232010,11650(Grant 91111138);the National Institute of Health(Grant 2R01DC005642-10A1).; Mechanical stimuli play critical roles in cardiovascular diseases,in which in vivo stresses in blood vessels present a great challenge to predict.Based on the structural-thermal coupled finite element method,we propos...; 关键词：CARDIOVASCULAR disease In VIVO stress MULTI-LAYER VESSEL structure HYPERTENSION Stenosed VESSEL

A Numerical Study of Passive Receptor-Mediated Endocytosis of Nanoparticles:The Effect of Mechanical Properties被引量：1: 《Computer Modeling in Engineering & Sciences》2018年第8期281-300,共20页Xinyue Liu Yunqiao Liu Xiaobo Gong Huaxiong Huang; This work was supported by the National Natural Science Foundations of China(11372191,11232010);the Natural Science and Engineering Research Council of Canada.; In this work,a three-dimensional axisymmetric model with nanoparticle,receptor-ligand bonds and cell membrane as a system was used to study the quasi-static receptor-mediated endocytosis process of spherical nanoparti...; 关键词：RECEPTOR-MEDIATED ENDOCYTOSIS NANOPARTICLE UPTAKE optimization method receptor-ligand BONDS drug delivery

Mechanobiology in vascular remodeling被引量：5: 《National Science Review》2018年第6期933-946,共14页Yue Han Kai Huang Qing-Ping Yao Zong-Lai Jiang; supported by the National Natural Science Foundation of China(11232010,11625209 and 31670958); Vascular remodeling is a common pathological process in cardiovascular diseases and includes changes in cell proliferation, apoptosis and differentiation as well as vascular homeostasis. Mechanical stresses, such as s...; 关键词：MECHANOBIOLOGY VASCULAR REMODELING cardiovascular disease MECHANOTRANSDUCTION ENDOTHELIAL CELL VASCULAR smooth muscle CELL nuclear envelope microRNA

血管力学生物学研究进展被引量：3: 《医用生物力学》2018年第S1期80-84,共5页齐颖新; 国家自然科学基金项目(11625209、31670958、11232010)资助; 2011年春天,我在美国加州大学圣迭戈分校(UCSD)短期访问学习期间有幸第一次拜访了冯元桢先生。还记得当天的天气是圣迭戈典型的阳光明媚,可是让我感触更为深刻的是冯先生睿智的思想、爽朗的笑声和对生物力学学科的热爱.冯先生和我讲到...; 关键词：血管力学应力诱导力学生物学血管重建低切应力分子机制生物学研究核骨架力学刺激细胞间信息交流

从生物力学到力学生物学的发展——为冯元桢先生百岁寿辰献礼被引量：1: 《医用生物力学》2018年第S1期22-26,共5页姜宗来; 国家自然科学基金项目(31670958、11625209、11232010)资助; 今年9月15日将迎来冯元桢先生的百岁华诞。回顾我国生物力学事业发展的历程,看到今天我国生物力学的蓬勃进步,作为亲历者深深地感恩冯先生,是在冯先生的大力推动和热情关怀下,生物力学作为一门新兴的交叉学科在我国起步和发展,又是在冯...; 关键词：生物力学冯先生细胞分子生物医学工程力学生物学

力-血管蛋白质组学研究进展被引量：1: 《医用生物力学》2017年第1期1-7,共7页齐颖新; 国家自然科学基金项目(11625209,11232010,11572199); 力学因素调控血管生理性稳态和病理性重建的机制是力学生物学中应力-生长研究的重要内容,迄今尚未完全阐明。蛋白质组学这一高通量、系统性的新技术在血管力学生物学领域的应用,将生物力学、蛋白质组学、生物信息学与分子生物学相关研...; 关键词：蛋白质组学应力血管重建力学生物学

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