国家自然科学基金(81320108027)

作品数：8被引量：63H指数：4
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相关作者：黄民李嘉丽王长希张桓熙刘龙山更多>>
相关机构：中山大学中山大学附属第六医院中山大学附属第一医院广州医科大学更多>>
相关期刊：《药学学报》《中国临床药理学杂志》《药学进展》《Acta Pharmacologica Sinica》更多>>
相关主题：药代动力学药物基因组学GLUTATHIONEACUTESIGNALING_PATHWAY更多>>
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Hepatic Vps33b deficiency aggravates cholic acid-induced cholestatic liver injury in male mice被引量：1
《Acta Pharmacologica Sinica》2022年第4期933-940,共8页Kai-li Fu Pan Chen Yan-ying Zhou Yi-ming Jiang Yue Gao Hui-zhen Zhang Li-huan Guan Cong-hui Wang Jun-ling Liu Min Huang Hui-chang Bi 
The work was supported by the National Natural Science Foundation of China(Grants:82025034,81973392,81320108027);the National Key Research and Development Program(Grant:2017YFE0109900);the Shenzhen Science and Technology Program(KQTD20190929174023858);the Key Laboratory Foundation of Guangdong Province(Grant:2017B030314030);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093);the National Engineering and Technology Research Center for New Drug Druggability Evaluation(Seed Program of Guangdong Province,2017B090903004).
Vacuolar protein sorting 33B (VPS33B) is important for intracellular vesicular trafficking process and protein interactions, which is closely associated with the arthrogryposis, renal dysfunction, and cholestasis synd...
关键词：CHOLESTASIS liver injury Vps33b bile acids METABONOMICS 
Nuclear receptors and non-alcoholic fatty liver disease:An update
《Liver Research》2020年第2期88-93,共6页Xiao Yang Frank J.Gonzalez Min Huang Huichang Bi 
The work was supported by the Natural Science Foundation of China(81973392,81320108027);the National Key Research and Development Program of China(2017YFE0109900);the Natural Science Foundation of Guangdong Province(2017A030310330,2017A030311018);China Postdoctoral Science Foundation(2019TQ0398);the Fundamental Research Funds for the Central Universities(19ykyjs34).
Non-alcoholic fatty liver disease(NAFLD)has become the leading cause of chronic liver disease in adults and children worldwide.The symptoms of NAFLD range from simple steatosis and non-alcoholic stea-tohepatitis(NASH)...
关键词：Nuclear receptors(NRs) Non-alcoholic fatty liver disease(NAFLD) Pregnane X receptor(PXR) Constitutive androstane receptor(CAR) Farnesoid X receptor(FXR) Peroxisome proliferator activated receptor (PPAR) Liver X receptor(LXR) 
Current trends in drug metabolism and pharmacokinetics被引量：17
《Acta Pharmaceutica Sinica B》2019年第6期1113-1144,共32页Yuhua Li Qiang Meng Mengbi Yang Dongyang Liu Xiangyu Hou Lan Tang Xin Wang Yuanfeng Lyu Xiaoyan Chen Kexin Liu Ai-Ming Yu Zhong Zuo Huichang Bi 
supported by National Natural Science Foundation of China(grants:81573489,81522047,81730103,81320108027,81660618,and 81773808);the National Key Research and Development Program(grant:2017YFE0109900 and 2017YFC0909303,China);the 111 project(grant:B16047,China);the Key Laboratory Foundation of Guangdong Province(grant:2017B030314030,China);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093,China);National Engineering and Technology Research Center for New drug Druggability Evaluation(Seed Program of Guangdong Province,2017B090903004,China);Natural Science Foundation of Guangdong(grant:2017A030311018 and 2015A030313124,China);National Institutes of Health(grants No.R01CA225958 and R01GM113888 to Ai-Ming Yu,USA).
Pharmacokinetics(PK)is the study of the absorption,distribution,metabolism,and excretion(ADME)processes of a drug.Understanding PK properties is essential for drug development and precision medication.In this review w...
关键词：PHARMACOKINETICS DRUG METABOLISM Drug-drug interactions Modeling Metabolizing ENZYMES Transporters Nuclear RECEPTORS Noncoding RNAS 
肾移植患者术后血浆mir-627-5p表达水平与他克莫司剂量校正谷浓度相关性研究被引量：2
《中国临床药理学杂志》2019年第10期963-966,共4页张亦舒 覃利 周守宁 刘龙山 张桓熙 王长希 黄民 李嘉丽 
国家自然科学基金资助项目(81320108027);广东省自然科学基金资助项目(2016A030313219)
目的探讨肾移植患者术后6～10d外周血中微小RNA(microRNA)水平与他克莫司(FK506)剂量校正谷浓度之间的相关性。方法纳入109例肾移植术后进行三联免疫疗法(麦考酚酸类药物+他克莫司+泼尼松)的患者。用miRcute增强型miRNA荧光定量检测试...
关键词：微小RNA 他克莫司 肾移植 药代动力学 
IMPDH1基因多态性与肾移植患者麦考酚酸类药物药效学的相关性分析
《药学学报》2018年第5期765-770,共6页周守宁 覃利 刘思 刘龙山 张亦舒 张桓熙 王长希 黄民 李嘉丽 
国家重点研发计划项目(2017YFC0909303;2016YFC0905001);国家自然科学基金资助项目(81320108027);广东省重点实验室建设项目(2011A060901014)
探讨IMPDH1基因多态性对肾移植患者麦考酚酸类药物药效学的影响。纳入315例肾移植术后进行三联免疫疗法(麦考酚酸类药物+他克莫司+泼尼松)的患者。采用Agena Mass ARRAY?方法检测患者IMPDH1基因型。通过高效液相色谱法检测术后稳定期患...
关键词：肾移植 麦考酚酸 药效学 急性排斥 感染 药物基因组学 
器官移植术后免疫抑制剂的药物基因组学研究进展被引量：6
《药学进展》2018年第4期243-258,共16页李嘉丽 黄民 
国家重点研发计划(No.2017YFC0909303;No.2016YFC0905001);国家自然科学基金(No.81320108027);广东省新药设计与评价重点实验室(No.2011A060901014)
器官移植是救治器官功能衰竭最有效的手段,但术后急、慢性排斥反应是导致移植物功能丧失的重要原因之一,因此免疫抑制剂的安全合理应用起着至关重要的作用。然而,临床常用免疫抑制剂普遍具有治疗窗窄、药代动力学及药效动力学个体差异...
关键词：器官移植 免疫抑制剂 药代动力学 药效动力学 药物基因组学 
三种小鼠酒精性肝病短期模型的评价被引量：10
《药学学报》2018年第2期236-243,共8页张译文 李昱锦 胡冰芳 黄民 
国家自然科学基金资助项目(81320108027);高等学校学科创新引智计划(111计划)资助项目(B16047).
酒精性肝病分为脂肪肝、脂肪型肝炎、肝纤维化和肝硬化;严重情况下会发展成肝癌,如今已经成为继病毒性肝炎之后我国第二大肝病。目前,针对上述疾病的动物模型较为繁杂,诱导指标单一,且与临床指标有较大差异。其中,有3种短期模型应用较...
关键词：酒精性肝病 CC族趋化因子2 白介素6 
Schisandrol B protects against acetaminophen- induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway被引量：27
《Acta Pharmacologica Sinica》2016年第3期382-389,共8页Yi-ming JIANG Ying WANG Hua-sen TAN Tao YU Xiao-mei FAN Pan CHEN Hang ZENG Min HUANG Hui-chang BI 
This study was financially supported by the National Natural Science Foundation of China （No 81373470 and 81320108027）, the Major Scientific and Technological Project （No 2012ZX09303012-002 and 2011A080300001）, Guang- dong Provincial Key Laboratory and Natural Science Foun- dation of Guangdong Province （No 2011A060901014 and S2012030006240）, and the National Science and Technology Support Plan Projects （No 2012BAI29B09）.
Aim： The nuclear factor erythroid 2-related factor 2 （NRF2） acts through the antioxidant response element （ARE） to regulate the expression of many detoxifying and antioxidant genes responsible for cytoprotective ...
关键词：ACETAMINOPHEN HEPATOTOXICITY schisandrol B Schisandra sphenanthera liver injury GLUTATHIONE NRF2 antioxidantresporse element 
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