国家自然科学基金(30800387)

作品数:12被引量:79H指数:7
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相关作者:章振林刘玉娟张浩胡伟伟柯耀华更多>>
相关机构:上海交通大学附属第六人民医院即墨市人民医院更多>>
相关期刊:《中华内科杂志》《中华骨质疏松和骨矿盐疾病杂志》《Acta Pharmacologica Sinica》《中国骨质疏松杂志》更多>>
相关主题:骨密度绝经后骨质疏松骨质疏松BONEPOLYMORPHISMS更多>>
相关领域:医药卫生生物学农业科学机械工程更多>>
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Contribution of Myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring被引量:10
《Acta Pharmacologica Sinica》2012年第5期660-667,共8页Hua YUE Jin-wei HE Hao ZHANG Chun WANG Wei-wei HU Jie-mei GU Yao-hua KE Wen-zhen FU Yun-qiu HU Miao LI Yu-juan LIU Song-hua WU Zhen-lin ZHANG 
Acknowledgements The study was supported by grants from the project of the National Natural Science Foundation of China (81170803, 81070692, 81000360, and 30800387), Shanghai Rising-star Program (11QA1404900), Shanghai Natural Science Foundation (11ZR1427300), STCSM10DZ1950100, and Academic Leaders in Health Sciences in Shanghai (XBR2011014).
Aim: Myostatin gene is a member of the transforming growth factor-β (TGF-β) family that negatively regulates skeletal muscle growth. Genetic polymorphisms in Myostatin were found to be associated with the peak bo...
关键词:MYOSTATIN single nucleotide polymorphism (SNPs) bone mineral density lean mass fat mass within-family association quantitative transmission disequilibrium test (QTDT) Chinese male 
Comparison of the effects of cholecalciferol and calcitriol on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency被引量:5
《Acta Pharmacologica Sinica》2012年第4期490-495,共6页Hao ZHANG Qi-ren HUANG Jie-mei GU Wei-wei HU Yu-juan LIU Yun-qiu HU Zhen-lin ZHANG 
Acknowledgements This study was supported by the National Natural Science Foundation of China (NSFC) (No 30800387, 30771019, 81070692, 81170803), Academic Leaders in Health Sciences in Shanghai (XBR2011014), STCSM10DZ1950100, Science and Technology commission of Shanghai municipality (11ZR1427300) and Shanghai Rising Star Project (No 11QA1404900).
Aim: To compare the effects of cholecalciferol (800 IU/d) and calcitriol (0.25 pg/d) on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency. Methods: One hundred Chi...
关键词:CHOLECALCIFEROL CALCITRIOL calcium metabolism bone turnover parathyroid hormone 25-hydroxyvitamin D β-CrossLaps oftype I collagen containing cross-linked C-telopeptide (β-CTX) postmenopausal women 
Hajdu—Cheney综合征一例并文献复习被引量:1
《中华内科杂志》2010年第12期1055-1057,共3页顾洁梅 章振林 
国家自然科学基金(30570891,30771019,30800387);上海市优秀学科带头人项目(08XD1403000)
Hajdu-Cheney综合征也称为遗传性骨发育不良并肢端溶骨症(MIM 102500),1948年Hajdu和Kauntze及1965年Cheney分别进行了病例报道.此后的几十例病例既有呈常染色体显性遗传,也有散发病例.国内仅有3例报道.该病是一种累及患者骨骼生长并...
关键词:罕见综合征 文献复习 常染色体显性遗传 病例报道 骨骼生长 肢端溶骨症 骨发育不良 散发病例 
Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families被引量:4
《Acta Pharmacologica Sinica》2010年第8期977-983,共7页Hao ZHANG Jin-wei HE Gao GAO Hua YUE Jin-bo YU Wei-wei HU Jie-mei GU Yun-qiu HU Miao LI Wen-zhen FU Yu-juan LIU Zhen-lin ZHANG 
Acknowledgements The study was supported by the National Natural Science Foundation of China (NSFC) (No 30570891, 30771019, and 30800387) and Program of Shanghai Chief Scientist (No 08XD1403000).
Aim: To determine the associations between HOXD4 gene polymorphisms with peak bone mineral density (BMD) throughing measuring three tagging single nucleotide polymorphisms (tagSNPs), including rs1867863, rs134180...
关键词:peak bone mineral density HOXD4 single nucleotide polymorphism quantitative transmission disequilibrium test 
维生素D受体基因和雌激素受体基因多态性与老年人低骨量的关系被引量:7
《中华骨质疏松和骨矿盐疾病杂志》2010年第3期171-177,共7页顾洁梅 何进卫 肖文金 胡伟伟 张浩 胡云秋 李淼 傅文贞 刘玉娟 汪纯 柯耀华 岳华 章振林 
国家自然科学基金(30570891,30771019和30800387);上海市科委优秀学科带头人计划(08XD1403000)
目的探讨维生素D受体基因(VDR)和雌激素受体基因(ESR1)多态性与老年男性、女性低骨量的关系。方法 378名老年男性[平均年龄(61.1±7.0)岁,其中260名健康男性、110例骨量减少和8例骨质疏松患者]和334名绝经后妇女[平均年龄(58.4±6.3)岁...
关键词:维生素D受体基因 雌激素受体基因1 单核苷酸多态性 骨量减少 骨质疏松 
骨硬化症致病基因研究进展被引量:11
《中华骨质疏松和骨矿盐疾病杂志》2010年第2期122-127,共6页柯耀华 章振林 
国家自然科学基金(30771019,30570819,30800387);上海市优秀学科带头人计划(08XD1403000)
骨硬化症(osteopetrosis)是一种以骨密度增高、破骨细胞缺乏或功能缺陷导致骨吸收障碍为特点的代谢性骨病,可分为常染色体隐性遗传(autosomal recessive osteopetrosis,ARO)和常染色体显性遗传(autosomal dominant osteopetrosis,ADO)...
关键词:骨硬化症 基因突变 
绝经后妇女740例脆性骨折部位与骨密度关系的分析被引量:16
《中国全科医学》2010年第4期372-373,376,共3页王萍萍 柯耀华 张浩 胡伟伟 胡云秋 李淼 傅文贞 刘玉娟 章振林 
国家自然科学基金资助项目(30771019,30570819,30800387);上海市优秀学科带头人计划(08XD1403000)
目的探讨绝经后妇女脆性骨折部位与骨密度(BMD)的关系。方法回顾性研究740例有脆性骨折的绝经后妇女,分析骨折部位和次数与BMD关系,应用双能X线吸收仪检测腰椎1~4和股骨近端BMD值。结果740例患者中,共发生838次骨折,椎体骨折、髋部骨...
关键词:骨质疏松 骨密度脆性骨折 绝经后妇女 
Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families被引量:8
《Acta Pharmacologica Sinica》2009年第12期1634-1642,共9页Jie-mei GU Wen-jin XIAO Jin-wei HE Hao ZHANG Wei-wei HU Yun-qiu HU Miao LI Yu-juan LIU Wen-zhen FU Jin-bo YU Gao GAO Hua YUE Yao-hua KE Zhen-lin ZHANG 
Acknowledgements The study was supported by the National Natural Science Foundation of China (NSFC) (No 30570891, 30771019, and 30800387) and Program of Shanghai Chief Scientist (Project No 08XD1403000). We wish to thank three anonymous reviewers for comments that helped to improve the manuscript and our future research.
Aim: The goal of this study was to determine whether polymorphisms in the vitamin D receptor (VDR) and estrogen receptor alpha (ESR1) genes are associated with variations of peak bone mineral density (BMD) and ...
关键词:VDR ESR1 POLYMORPHISM bone mineral density fat mass lean mass transmission disequilibrium test 
护骨素基因多态性与阿仑膦酸钠治疗绝经后骨质疏松骨密度变化的关系被引量:3
《中华医学杂志》2009年第42期2958-2962,共5页汪纯 何进卫 秦跃娟 张浩 胡伟伟 刘玉娟 章振林 
国家自然科学基金(30570891,30771019,30800387);上海市科委优秀学科带头人计划资助项目(08XD1403000)
目的探讨护骨素(OPG)基因多态性是否与绝经后骨质疏松病人阿仑膦酸钠治疗后骨密度的变化有关,明确是否存在与疗效有关的基因型。方法人选80例绝经后骨质疏松病人,平均年龄(64.2±7.7)岁,口服阿仑膦酸钠(福善美)70mg每周1次...
关键词:骨质疏松 绝经后 基因 阿仑膦酸钠 骨密度 
Early onset Paget's disease of bone caused by a novel mutation (78dup27) of the TNFRSF11A gene in a Chinese family被引量:7
《Acta Pharmacologica Sinica》2009年第8期1204-1210,共7页Yao-hua KE Hua YUE Jin-wei HE Yu-juan LIU Zhen-lin ZHANG 
Acknowledgements This project was supported by the National Natural Science Foundation of China (No 30570891, 30771019, and 30800387) and the Program of Shanghai Subject Chief Scientist (No08XD1403000), We thank the patients for their participation.
Aim: A previous study showed that individuals of Japanese descent affected by early onset familial Paget's disease of bone (PDB) carried a 27-bp duplication at position 75 (75dup27) in the TNFRSF11A gene encodin...
关键词:Paget's disease of bone RANK MUTATION 
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