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国家重点基础研究发展计划(2011CB606206): 作品数：13被引量：20H指数：3; 导出分析报告; 相关作者：徐翔晖顾忠伟李海平何斌吴尧更多>>; 相关机构：四川大学更多>>; 相关期刊：《Chinese Journal of Polymer Science》《Regenerative Biomaterials》《Nano-Micro Letters》《Science China Chemistry》更多>>; 相关主题：DENDRIMERSSELF-ASSEMBLYBIODEGRADABLEPEPTIDEDENDRIMER更多>>; 相关领域：化学工程医药卫生理学一般工业技术更多>>

A magnetic hydroxyapatite composite scaffoldbased magnetic therapy for bone repair:an experimental study in canis lupus familiaris被引量：1: 《Regenerative Biomaterials》2017年第2期97-103,共7页Jing He Hao Hu Xiaobo Zeng Fang Lan Fang Wu Yao Wu; The authors are grateful to the financial support of National Basic Research Program of China(973 program,No.2011CB606206);National Natural Science Foundation of China(Nos.51273127,31070849,and 31600765);Program for New Century Excellent Talents in University(No.NCET-11-0350);Program for Miaozi in Sichuan province(No.2016RZ0032).; While the beneficial effect of magnetic nanoparticle on the biological functions of calcium phosphate scaffolds has been well documented,little is known about the effect of magnetic nanoparticle on the in vivo perform...; 关键词：magnetic nanoparticles static magnetic fields magnetic hydroxyapatite bone regeneration

Biodegradable polymeric nanoparticles based on amphiphilic principle:construction and application in drug delivery被引量：5: 《Science China Chemistry》2014年第4期461-475,共15页ZHANG ShiYong WU Yao HE Bin LUO Kui GU ZhongWei; supported by the National Basic Research Program of China(2011CB606206);the National Natural Science Foundation of China(21372170,51133004 and 81361140343);the Recruitment Program ofGlobal Young Experts of China,the Setup Foundation of Sichuan University(YJ201317);the Excellent Young Teachers Program of SichuanUniversity(2082604164235); The use of nanotechnology in drug-delivery systems(DDS) is attractive for advanced diagnosis and treatment of cancer diseases. Biodegradable polymeric nanoparticles, for example, have promising applications as advance...; 关键词：biodegradable polymer miceUe AMPHIPHILICITY drug-delivery system CANCER

Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery: 《Nano-Micro Letters》2014年第2期108-115,共8页Longgui Zhang Ting Su Bin He Zhongwei Gu; supported by National Science Foundation for Excellent Young Scholars (No. 51222304);National Science Foundation of China (NSFC, No.31170921,51133004);National Basic Research Program of China (National 973 program, No. 2011CB606206);program for Changjiang Scholars and Innovative Research Team in University (IRT1163); α-Cyclodextrin/poly(ethylene glycol)(α-CD/PEG) polyrotaxane nanoparticles were prepared via a self-assembly method. Anticancer drug methotrexate(MTX) was loaded in the nanoparticles. The interaction between MTX and ...; 关键词：Polyrotaxane nanoparticles Drug delivery METHOTREXATE Anticancer activity

Preparation and Biosafety Evaluation of the Peptide Dendron Functionalized Mesoporous Silica Nanohybrid: 《Chinese Journal of Chemistry》2014年第1期27-36,共10页Dayi Pan Chunhua Guo Kui Luo Zhongwei Gu; The work was supported by National Basic Research Program of China (National 973 program,No.2011CB606206),National Natural Science Foundation of China (51133004 and 81101099) and the Excellent Young Teachers Program of Sichuan University (2012SCU04A06).; Mesoporous silica nanoparticles (MSNs) have been extensively studied and proposed as promising candidates for numerous biomedical applications.In this study,we report the design,preparation,characterization and biosaf...; 关键词：mesoporous silica nanoparticles peptide dendrimer NANOHYBRID toxicity BIOSAFETY

Effect of serum on PEGylated quantum dots:Cellular uptake and intracellular distribution: 《Progress in Natural Science:Materials International》2013年第6期566-572,共7页Yeting Jian Xianghui Xu Yunkun Li Zhongwei Gu; supported by National Science Foundation of China(NSFC,No.51133004);National Basic Research Program of China(National 973 program,No.2011CB606206);Joint Sino-German Research Project(No.GZ756); Protein adsorption is closely related with the interactions between nanoparticles and physiological systems,and further influences the cellular uptake and distribution of nanoparticles in cells.Although polyethylene g...; 关键词：PEGylated QDS Protein adsorption CELLULAR UPTAKE INTRACELLULAR distribution

A comparative study of proliferation and osteogenic differentiation of rat adipose-derived stem cells in β-tricalcium phosphate (β-TCP), forsterite (Mg_2SiO_4 ) and clinoenstatite (MgSiO_3)被引量：2: 《Chinese Science Bulletin》2013年第24期3033-3042,共10页LENG Bin JIN XiaoGang LIN QiuXia CHEN Lei WANG Yan DU ZhiYan LIN KaiLi CHANG Jiang GU XiaoMing WANG ChangYong; supported by the National Natural Science Foundation of China (30730034);the National Basic Research Program of China(2011CB606206); In this study, the effects of forsterite and clinoenstatite powder extracts on the proliferation and osteogenic differentiation of rat adipose-derived stem cells (ASCs) were investigated and compared with the β-trica...; 关键词：脂肪干细胞成骨分化细胞增殖镁橄榄石 TCP相磷酸三钙 Mg2SiO4 MgSiO3

Synthesis of peptide dendrimers with polyhedral oligomeric silsesquioxane cores via click chemistry被引量：3: 《Chinese Chemical Letters》2013年第10期917-920,共4页Yu-Ji Pu Hui Yuan Ming Yang Bin He Zhong-Wei Gu; supported by the National Basic Research Program of China(National 973 program,No.2011CB606206);National Science Foundation of China(NSFC,Nos.31170921,51133004);the National Science Foundation for Excellent Young Scholars(No.51222304);Program for Changjiang Scholars and Innovative Research Team in University(No.IRT1163); Inorganic polyhedral oligomeric silsesquioxane （POSS） was used as the core for the synthesis of poly（t- lysine） peptide dendrimer via copper-catalyzed azide-alkyne click chemistry. The inorganic/organic composite ...; 关键词：Peptide dendrimer Polyhedral oligomeric silsesquioxane Click chemistry

STUDIES ON THE DEGRADATION OF POLY(L-LACTIDE-r-TRIMETHENE CARBONATE) COPOLYMERS: 《Chinese Journal of Polymer Science》2013年第7期966-973,共8页Yuan-lin Li Sai Li Li-jie Ji Bin He 顾忠伟; financially supported by the National Basic Research Program of China (National 973 program,No. 2011CB606206);the National Natural Science Foundation of China (Nos. 50830105, 51133004);Program for New Century Excellent Talents in Universities, Ministry of Education (MOE, NCET-10-0564);Program for Changjiang Scholars and Innovative Research Teams in Universities (IRT1163); Biodegradable poly（L-lactide-r-trimethene carbonate） copolymers （P（LLA-co-TMC）） with different compositions were synthesized. The degradation of the copolymers was carried out in phosphate buffer saline solutio...; 关键词：COPOLYMER Poly（L-lactide-r-trimethene carbonate） DEGRADATION Crystallization.

Novel PLGGE graft polymeric micelles for doxorubicin delivery被引量：1: 《Chinese Science Bulletin》2012年第31期3994-4004,共11页YU ZuXiao HE Bin SHENG MingMing WANG Gang GU ZhongWei; supported by the National Basic Research Program of China (2011CB606206);the National Natural Science Foundation of China(50830105, 51133004 and 31170921);the Key Program for the International S&T Collaboration Projects of China (2010DFA51550);the Program for New Century Excellent Talents in University, Ministry of Education (NCET-10-0564);Department of Education of the Sichuan Province, China (09ZC056); Novel poly{(lactic acid)-co-[(glycolic acid)-alt-(L-glutamic acid)]}-g-monomethyl poly(ethylene glycol) (PLGGE) micelles were prepared and used as carriers for anti-tumor drug delivery. Three PEGylated PLGG copolymers...; 关键词：聚合物胶束阿霉素 HepG2细胞交付两亲性共聚物激光共聚焦显微镜透射电子显微镜聚乙二醇化

肽类树状大分子及其生物医学应用被引量：1: 《中国材料进展》2012年第5期20-29,39,共11页佘汶川徐翔晖王刚罗奎顾忠伟; 国家“973计划”项目(2011CB606206);国家自然科学基金项目(51133004,81101099,30970730); 肽类树状大分子是近年来发展起来的一类新型生物医用高分子材料,它除了具有普通树枝状分子的特征如规整性、高度支化、表面呈现高密度功能团、尺度为纳米级、单一分子量等之外,同时还具有类似蛋白一样的球状结构、优良的生物相容性、水...; 关键词：肽类树状大分子分子探针药物载体基因载体

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