国家重点基础研究发展计划(2010CB912700)

作品数：7被引量：20H指数：3
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相关机构：军事医学科学院国防科学技术大学复旦大学更多>>
相关期刊：《Science China(Life Sciences)》《Science China Chemistry》《生物化学与生物物理进展》《生物工程学报》更多>>
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Path PPI: an integrated dataset of human pathways and protein-protein interactions被引量：2
《Science China(Life Sciences)》2015年第6期579-589,共11页TANG HaiLin ZHONG Fan LIU Wei HE FuChu XIE HongWei 
supported by the National High Technology Research and Development Program of China(2012AA020201);National Basic Research Program of China(2013CB910802,2010CB912700);International Science&Technology Cooperation Program of China(2014DFB30020);National Natural Science Foundation of China(31000379,31000587,31000591);Chinese State Key Project Specialized for Infectious Diseases(2012ZX10002012-006)
Integration of pathway and protein-protein interaction(PPI) data can provide more information that could lead to new biological insights. PPIs are usually represented by a simple binary model, whereas pathways are rep...
关键词：databases integration PATHWAY protein-protein interaction PROTEOMICS 
原核生物蛋白质基因组学研究进展被引量：3
《生物工程学报》2014年第7期1026-1035,共10页张成普 徐平 朱云平 
国家重点基础研究计划(973计划)(Nos.2011CB910600,2010CB912700,2013CB911200);国家高技术研究发展计划(863计划)(Nos.2012AA020409,2012AA020201);国家自然科学基金(Nos.21105121,21275160);北京市自然科学基金(No.5122013)资助~~
随着基因组测序技术的不断发展,大量微生物基因组序列可以在短时间内得以准确鉴定。为了进一步探究基因组的结构与功能,基于序列特征与同源特征的基因组注释算法广泛应用于新测序物种。然而受基因组测序质量以及算法本身准确性偏低等问...
关键词：蛋白质基因组学 原核生物 基因组注释 质谱 
Meta-analysis在多种组学领域的应用被引量：2
《生物工程学报》2014年第7期1094-1104,共11页韩明飞 朱云平 
国家重点基础研究发展计划(973计划)(Nos.2011CB910600,2010CB912700,2013CB911200);国家高技术研究发展计划(863计划)(Nos.2012AA020409,2012AA020201);国家自然科学基金(Nos.21105121,21275160);北京市自然科学基金(No.5122013)资助~~
Meta-analysis作为一种整合多特征、多数据的统计方法,上世纪90年代被引入生命科学领域。随着高通量测序技术的快速发展,以基因组学、转录组学和蛋白质组学为核心的生命组学逐渐成为生命科学研究的新热点。海量数据的快速产出推动了组...
关键词：META-ANALYSIS 基因组学 转录组学 蛋白质组学 
Response of peptide intensity to concentration in ESI–MS-based proteome被引量：1
《Science China Chemistry》2014年第5期686-694,共9页LU WenYuan YIN XueFei LIU XiaoHui YAN GuoQuan YANG PengYuan 
supported by the National Basic Research Program of China(2010CB912700,2013CB911201,2011CB910600);the National High Technology Research and Development Program of China(2012AA020203,2014AAQ00361);the National Natural Science Foundation of China(21227805)
High-throughput quantification with label-free methods has received considerable attention in electrospray ionization(ESI)-mass spectrometry(MS),but the manner by which MS signals respond to peptide concentration rema...
关键词：peptide quantification ESI-MS peptide intensity peptide concentration interference 
Plasma biomarker screening for liver fibrosis with the N-terminal isotope tagging strategy被引量：6
《Science China(Life Sciences)》2011年第5期393-402,共10页LI ShuLong LIU Xin WEI Lai WANG HuiFen ZHANG JiYang WEI HanDong QIAN XiaoHong JIANG Ying HE FuChu 
supported by the National Basic Research Program of China(Grant Nos.2011CB910601,2011CB910700,2010CB912700 and 2011CB505304);the National High Technology Research and Development Program of China (Grant No.2006AA02A308);National Natural Science Foundation of China(Grant Nos.30700356,30700988,30972909,81000192,81001470 and 81010064);Chinese State Key Project Specialized for Infectious Diseases (Grant Nos.2008ZX10002-016 and 2009ZX10004-103);the National Key Technologies R&D Program for New Drugs (Grant No.2009ZX09301-002);the International Scientific Collaboration Program (Grant Nos.2009DFB33070 and 2010DFA31260);State Key Laboratory of Proteomics(Grant Nos.SKLP-Y200901 and SKLP-O200901)
A non-invasive diagnostic approach is crucial for the evaluation of severity of liver disease,treatment decisions,and assessing drug efficacy.This study evaluated plasma proteomic profiling via an N-terminal isotope t...
关键词：quantitative proteomics fiver fibrosis BIOMARKER PLASMA hepatitis B virus 
Comparison of alternative extraction methods for secretome profiling in human hepatocellular carcinoma cells被引量：8
《Science China(Life Sciences)》2011年第1期34-38,共5页CAO Jing SHEN ChengPin ZHANG Jun YAO Jun SHEN HuaLi LIU YinKun LU HaoJie YANG PengYuan 
supported by the National Natural Science Foundation of China (Grant No. 209750240);the National Basic Research Program of China (Grant No. 2010CB912700)
Secreted proteins are important sources for early detection and diagnosis of disease, and as such have received considerable attention. The extraction of low concentration proteins from large volumes of culture media,...
关键词：hepatocellular carcinoma SECRETOME protein extraction ULTRAFILTRATION precipitation DIALYSIS LC-MS/MS 
一种基于基因表达模型识别酵母细胞周期条件特异调控子网的方法(英文)被引量：1
《生物化学与生物物理进展》2010年第4期402-415,共14页刘齐军 王正华 刘万霖 李栋 贺福初 朱云平 
supported by grants from The State Key Laboratory of Proteomics(SKLP-O200811);The National Natural Science Foundation of China (60603054, 30800200, 30621063);National Basic Research Program of China (2006CB910803, 2006CB910706, 2010CB912700);Hi-Tech Research and Development Program of China (2006AA02A312);National S&T Major Project (2008ZX10002-016, 2009ZX09301-002)~~
由高通量微阵列技术产生的数据集可以用于解释生物系统基因调控的未知机制.生物过程是动态的,所以很有必要关注某些条件下特异的基因调控子网络.细胞周期是一个基本的细胞过程,识别酵母的细胞周期特异调控子网是理解细胞周期过程的基础...
关键词：基因调控网络 细胞周期 基因表达模型 条件特异子网 微分方程模型 
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