Over the past two decades,proteolysis-targeting chimeras(PROTACs)have gradually evolved from chemical biology tools into potential clinical candidates,marking a significant advancement in our ability to modulate prote...
supported by the National Natural Science Foundation of China(Nos.82300345,3217003,32370099,and 81901287);the National High-Level Hospital Clinical Research Funding(2023-GSP-QN-23,China);the Provincial-level Talent Program for National Center of Technology Innovation for Biopharmaceuticals(NCTIB2024JS0101,China);the Suzhou Top-Notch Talent Groups(ZXD2022003,China).
Despite the enormous progress made in microbiome research,a comprehensive and universally accepted framework for identifying healthy microbiome biomarkers remains elusive.Defining what constitutes a"healthy"gut microb...
Acta Pharmaceutica Sinica B is an English language bimonthly peer-reviewed journal published online in ScienceDirect which invites research articles,reviews and communications in all areas of the pharmaceutical scienc...
supported by the National Natural Science Foundation of China(Grant No.32271220).
Neurons are the main organizers of neurological activities in the brain.However,its role remains largely unknown in regulating waste clearance in the brain.This issue is addressed in a recent study published in Nature...
supported by the Postdoctoral Fellowship Program of CPSF(No.GZC20230333,China).
Nanomedicines have revolutionized disease prevention,diagnosis,and treatment.Since the approval of Liposomal doxorubicin(Doxil)in 1995,various nanomedicines have been successfully developed1.Specifically,the COVID-19 ...
supported by the National Natural Science Foundation of China(82072060);the Open Research Fund of State Key Laboratory of Southwestern Chinese Medicine Resources(SKLTCM2022067,China).
Gamma-delta(γδ)T cells exhibit tissue tropism and possess antitumor activity that is independent of new antigen load and traditional MHC-dependent antigen presentation.These cells also present characteristics typica...
Recently,a novel radiotracer,[^(18)F]QTFT,synthesized by Li's group1 and published in Acta Pharmaceutica Sinica B,was identified as a PET tracer capable of specifically visualize the anti-inflammatory microglia target...
Acute liver failure(ALF)is a life-threatening condition characterized by severe liver dysfunction1.It is primarily caused by bacterial invasion,viral infections(e.g.,hepatitis B or E),or hepatotoxic drugs,notably acet...
The authors regret Fig.5C in the published article contained an incorrect image.Specifically,the image for the MHCC97H(pLVX-Puro)/DC group was mistakenly used during copying and pasting in the process of assembling th...
The authors regret that there was an error in the use of GAPDH image in PANC-1 cells of Fig.5B due to mistakenly pasting in the process of assembling figures.The wrong data are replaced by right ones of the same batch...