《Acta Pharmaceutica Sinica B》

作品数:2410被引量:9623H指数:38
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《Acta Pharmaceutica Sinica B》
主办单位:中国药学会;中国医学科学院药物研究所
最新期次:2025年2期更多>>
发文主题:AUTHORSINFORMATIONACTASINICAJOURNAL更多>>
发文领域:医药卫生文化科学理学化学工程更多>>
发文基金:国家自然科学基金中国博士后科学基金国家重点基础研究发展计划高等学校学科创新引智计划更多>>
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TransTACs:Transforming antibodies into targeted protein degraders
《Acta Pharmaceutica Sinica B》2025年第2期1186-1188,共3页Yu Guo Jinxin Che Xiaowu Dong 
Over the past two decades,proteolysis-targeting chimeras(PROTACs)have gradually evolved from chemical biology tools into potential clinical candidates,marking a significant advancement in our ability to modulate prote...
关键词:Targeted protein degradation Membrane and extracellular proteins Transferrin receptor-targeting chimeras Protein homeostasis regulation Tumor therapy 
Unlocking the healthy human microbiome:Redefining core microbial signatures
《Acta Pharmaceutica Sinica B》2025年第2期1189-1192,共4页Shuting Xi Diya Jiang Qianyi Zhou Hairong Lyu Anita Y.Voigt Xin Zhou Zhemin Zhou Yuan Huang 
supported by the National Natural Science Foundation of China(Nos.82300345,3217003,32370099,and 81901287);the National High-Level Hospital Clinical Research Funding(2023-GSP-QN-23,China);the Provincial-level Talent Program for National Center of Technology Innovation for Biopharmaceuticals(NCTIB2024JS0101,China);the Suzhou Top-Notch Talent Groups(ZXD2022003,China).
Despite the enormous progress made in microbiome research,a comprehensive and universally accepted framework for identifying healthy microbiome biomarkers remains elusive.Defining what constitutes a"healthy"gut microb...
关键词:Gut health GUILDS BIOMARKER Causal inference 
Information for Authors
《Acta Pharmaceutica Sinica B》2025年第2期I0005-I0008,共4页
Acta Pharmaceutica Sinica B is an English language bimonthly peer-reviewed journal published online in ScienceDirect which invites research articles,reviews and communications in all areas of the pharmaceutical scienc...
关键词:COMMUNICATIONS research articles pharmaceutical sciences acta pharmaceutica sinica REVIEWS 
Neuronal activities drive brain waste clearance through the glymphatic system
《Acta Pharmaceutica Sinica B》2025年第2期1193-1195,共3页Lin-jian Wang Xiwen Ma Jianping Ye 
supported by the National Natural Science Foundation of China(Grant No.32271220).
Neurons are the main organizers of neurological activities in the brain.However,its role remains largely unknown in regulating waste clearance in the brain.This issue is addressed in a recent study published in Nature...
关键词:Alzheimer disease NEURON Glymphatic system Cerebrospinal fluid perfusion Brain clearance 
DELIVER:The core principles for the clinic translation of nanomedicines
《Acta Pharmaceutica Sinica B》2025年第2期1196-1198,共3页Chuan Hu Xinling He Huile Gao Jinming Zhang 
supported by the Postdoctoral Fellowship Program of CPSF(No.GZC20230333,China).
Nanomedicines have revolutionized disease prevention,diagnosis,and treatment.Since the approval of Liposomal doxorubicin(Doxil)in 1995,various nanomedicines have been successfully developed1.Specifically,the COVID-19 ...
关键词:NANOMEDICINES Clinic translation DELIVER 
Oral garlic-derived nanoparticles improve cancer immunotherapy
《Acta Pharmaceutica Sinica B》2025年第2期1199-1201,共3页Kun Yang Jinming Zhang Bo Xiao 
supported by the National Natural Science Foundation of China(82072060);the Open Research Fund of State Key Laboratory of Southwestern Chinese Medicine Resources(SKLTCM2022067,China).
Gamma-delta(γδ)T cells exhibit tissue tropism and possess antitumor activity that is independent of new antigen load and traditional MHC-dependent antigen presentation.These cells also present characteristics typica...
关键词:Oral administration Garlic-derived nanoparticle Cancer IMMUNOTHERAPY 
[^(18)F]QTFT,a nicotinate-based radiotracer targeting P2Y_(12)with satisfactory blood-brain barrier(BBB)permeability
《Acta Pharmaceutica Sinica B》2025年第2期1202-1204,共3页Ying-Qi Song Chunquan Sheng 
Recently,a novel radiotracer,[^(18)F]QTFT,synthesized by Li's group1 and published in Acta Pharmaceutica Sinica B,was identified as a PET tracer capable of specifically visualize the anti-inflammatory microglia target...
关键词:[^(18)F]QTFT P2Y_(12)receptor Blood-brain barrier(BBB) Positron emission tomography(PET) GLIOMA 
Harnessing the UDP-G/P2Y_(14)R axis to promote liver regeneration in acute liver failure
《Acta Pharmaceutica Sinica B》2025年第2期1205-1206,共2页Jian-Hong Fang Huichang Bi 
Acute liver failure(ALF)is a life-threatening condition characterized by severe liver dysfunction1.It is primarily caused by bacterial invasion,viral infections(e.g.,hepatitis B or E),or hepatotoxic drugs,notably acet...
关键词:Acute liver failure UDP-G P2Y_(14)R Liver regeneration 
Author correction to“Generation ofαGal-enhanced bifunctional tumor vaccine”[Acta Pharm Sin B 12(2022)3177-3186]
《Acta Pharmaceutica Sinica B》2025年第2期1207-1207,共1页Jian He Yu Huo Zhikun Zhang Yiqun Luo Xiuli Liu Qiaoying Chen Pan Wu Wei Shi Tao Wu Chao Tang Huixue Wang Lan Li Xiyu Liu Yong Huang Yongxiang Zhao Lu Gan Bing Wang Liping Zhong 
The authors regret Fig.5C in the published article contained an incorrect image.Specifically,the image for the MHCC97H(pLVX-Puro)/DC group was mistakenly used during copying and pasting in the process of assembling th...
关键词:generation figure correction copying pasting bifunctional tumor vaccine mhcc h plvx puro dc group original data access GAL 
Author correction to“The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells”[Acta Pharm Sin B 12(2022)210-227]
《Acta Pharmaceutica Sinica B》2025年第2期1208-1209,共2页Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao 
The authors regret that there was an error in the use of GAPDH image in PANC-1 cells of Fig.5B due to mistakenly pasting in the process of assembling figures.The wrong data are replaced by right ones of the same batch...
关键词:mistakenly pasting assembling figuresthe er stress yap APOPTOSIS wrong data gapdh image pancreatic cancer 
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