supported by the Ministry of Science and Technology of China(STI2030-2021ZD0202300);the National Natural Science Foundation of China(32070971,32100768,32200776,and 32200792);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)。
Human’s robust cognitive abilities,including creativity and language,are made possible,at least in large part,by evolutionary changes made to the cerebral cortex.This paper reviews the biology and evolution of mammal...
supported by the National Natural Science Foundation of China(82371300);Zhejiang Provincial Natural Science Foundation of China(LY23H090014);Zhejiang Province Traditional Chinese Medicine Science and Technology Project(2024ZL1215).
Stroke,a major cerebrovascular disease,has high morbidity and mortality.Effective methods to reduce the risk and improve the prognosis are lacking.Currently,uric acid(UA)is associated with the pathological mechanism,p...
supported by the Natural Science Foundation of Zhejiang Province(LZ23C090001,LY23H090001);the National Natural Science Foundation of China(82071230).
Yes-associated protein (YAP), the key transcriptional co-factor and downstream effector of the Hippo pathway, has emerged as one of the primary regulators of neural as well as glial cells. It has been detected in vari...
supported by the Natural Science Foundation of Guangdong Province(2022A1515010297);the National Natural Science Foundation of China(32100765);the Xiamen Medical Health Science and Technology Project(3502Z20194098);the Shenzhen-Hong Kong-Macao Science and Technology Innovation Project(SGDX2020110309280100).
Dear Editor,Sturge-Weber Syndrome(SWS)is a rare congenital neurocutaneous syndrome[1,2],with an estimated prevalence of 0.19 in 100,000 annually[3].It is a non-hereditary disease linked to a somatic mutation in the GN...
supported by the National Key R&D Program of China(2020YFE0205900 and 2022YEF0203200);the STI 2030-Major Project(2021ZD0200104 and 2022ZD0205203);the Shenzhen Science and Technology Program(RCYX20210706092100003,RCBS20221008093311027,and JCYJ20210324102006018);the Youth Innovation Promotion Association CAS(2022367);the Shenzhen Technological Research Center for Primate Translational Medicine grant(XMHT20220104005).
Dear Editor,The primary motor cortex,also known as MOp in rodents,F1,or M1 in primates[1],plays a crucial role in autonomous motor control.It is interconnected with other motor control structures such as the basal gan...
supported by the National Natural Science Foundation of China(32371066);the Guangdong Basic and Applied Basic Research Foundation(2022A1515010134);the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(NYKFKT2019009);the Shenzhen Technological Research Center for Primate Translational Medicine(XMHT20220104005).
AMPA Receptor and PET Tracer Limitation.The alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid receptor(AMPAR)is a subtype of ionotropic glutamate receptor.It functions as a ligand-gated ion channel and is primar...
supported by the National Natural Science Foundation of China(T2241028);STI2030-Major Projects[2021ZD0203000(2021ZD0203003)].
Mental health disorders have emerged as a critical global health challenge,profoundly impacting individuals,communities,and societies worldwide.The prevalence of mental health problems has been steadily increasing,wit...
supported by the National Natural Science Foundation of China(32300959);a Guangzhou Scientific Research Grant(SL2024A04J00578);the SCNU Young Faculty Development Program(22KJ04).
Neuron glia antigen-2(NG2)glia,also known as oligodendrocyte precursor cells(OPCs),are essential for maintaining the normal function and structure of the central nervous system(CNS)due to their supportive role[1].Unde...
supported by the National Natural Science Foundation of China(U21A20418).
Sleep is an indispensable part of life−its deficiency has significant implications for overall health and wellbeing[1].In today’s fast-paced society,sleep loss from either stressful or non-stressful origins has becom...