《Protein & Cell》

作品数：1591被引量：7099H指数：32
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《Protein & Cell》
主办单位：Higher Education Press;Biophysical Society of China
最新期次：2025年2期更多>>
发文主题：CRYSTAL_STRUCTUREHUMANPIONEERCANCERAGING更多>>
发文领域：生物学医药卫生农业科学理学更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>
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Cas7 meets Cas14:a strategic partnership in the typeⅦCRISPR-Cas
《Protein & Cell》2025年第2期79-82,共4页Yao Liu Senfeng Zhang Chunyi Hu 
National University of Singapore Presidential Young Professorship(PYP):23-0178-A0001;Singapore Ministry of Education Tier 1 grant:23-1065-P0001。
CRISPR(clustered regularly interspaced short palindromic repeats)-Cas systems,fundamental to prokaryotic adaptive immunity,are divided into two major classes based on their effector protein composition.Class 1 systems...
关键词：CRISPR COMPOSITION utilize 
Alzheimer's disease:insights into pathology,molecular mechanisms,and therapy
《Protein & Cell》2025年第2期83-120,共38页Qiuyang Zheng Xin Wang 
supported by the National Key R&D Program of China(2021ZD0202402 and 2021YFA1101401 to X.W.);the National Natural Science Foundation of China(82325018 and U21A20358 to X.W.,82271451 to Q.Z.);the Natural Science Foundation of Fujian Province of China(2021J02004 to X.W.);the Guangdong Basic and Applied Basic Research Foundation(2021B1515120081 to X.W.);the Fundamental Research Funds for the Chinese Central Universities(20720230070 to X.W.and Q.Z.,20720220052 to Q.Z.)。
Alzheimer's disease(AD),the leading cause of dementia,is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain.This condition casts a significant shadow on global health due to ...
关键词：Alzheimer's disease PATHOPHYSIOLOGY risk factors biomarkers prevention 
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune
《Protein & Cell》2025年第2期121-135,共15页Mei-Mei Zhao Ting-Ting Ren Jing-Kang Wang Lu Yao Ting-Ting Liu Ji-Chao Zhang Yang Liu Lan Yuan Dan Liu Jiu-Hui Xu Peng-Fei Tu Xiao-Dong Tang Ke-Wu Zeng 
financially supported by National Natural Sciences Foundation of China(82325050);National Key R&D Program of China(2022YFC3501601);Beijing Municipal Natural Science Foundation(7232273);Jinan New 20 Policies for Higher Education Funding(202228048);Natural Science Foundation of Shandong Province(Joint Foundation for Innovation and Development)(ZR2022LZY021)。
Pyroptosis is an identified programmed cell death that has been highly linked to endoplasmic reticulum(ER)dynamics.However,the crucial proteins for modulating dynamic ER membrane curvature change that trigger pyroptos...
关键词：PYROPTOSIS ER membrane antitumor immune OSTEOSARCOMA chemical degrader reticulon-4(RTN4) 
RADICAL:a rationally designed ion channel activated by ligand for chemogenetics
《Protein & Cell》2025年第2期136-142,共7页Heng Zhang Zhiwei Zheng Xiaoying Chen Lizhen Xu Chen Guo Jiawei Wang Yihui Cui Fan Yang 
supported by funding from the National Natural Science Foundation of China(32122040 and 31971040 to F.Y.;32071017 and 31922031 to Y.C.);Zhejiang Provincial Natural Science Foundation of China(LR20C050002 to F.Y.);China Postdoctoral Program for Innovative Talents(BX20230323 to H.Z.);China Postdoctoral Science Foundation(2024M752858 to H.Z.);The Fundamental Research Funds for the Central Universities(226-2022-00227 to F.Y.;226-2022-00149 to Y.C.);Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(NYKFKT2019001 to Y.C.);The Fundamental Research Funds for the Central Universities(226-2022-00227 to F.Y.)。
Dear Editor,Manipulating neuronal activities by exogenous means is always much desired in the field of neuroscience and beyond.Though many optogenetics and chemogenetics tools,such as channelrhodopsins and DREADDs(Arm...
关键词：RATIONAL CHANNEL LIMITATIONS 
Antiviral activity of lipoxygenase against severe fever with thrombocytopenia syndrome virus
《Protein & Cell》2025年第2期143-147,共5页Shuang Li Xiaojie Zheng Yunfa Zhang Lingyu Zhang Tong Yang Hao Li Caiyu Zhou Xiao-Ai Zhang Li-Zeng Gao Wei Liu 
supported by the National Natural Science Foundation of China(22121003)。
Dear Editor,Severe fever with thrombocytopenia syndrome(SFTS)is an emerging tick-borne infectious disease caused by Dabie bandavirus,also known as SFTS virus(SFTSV),a novel phlebovirus in the family Phenuiviridae of t...
关键词：FEVER THROMBOCYTOPENIA 
Lcn2 secreted by macrophages through NLRP3 signaling pathway induced severe pneumonia
《Protein & Cell》2025年第2期148-155,共8页Mingya Liu Feifei Qi Jue Wang Fengdi Li Qi Lv Ran Deng Xujian Liang Shasha Zhou Pin Yu Yanfeng Xu Yaqing Zhang Yiwei Yan Ming Liu Shuyue Li Guocui Mou Linlin Bao 
supported by the National Research and Development Project of China(grant no.2023YFF0724800);the CAMS Initiative for Innovative Medicine of China(grant no.2021-I2M-1-035);the Sector Fund(2060302);Young Elite Scientists Sponsorship Program by CAST(YESS)(grant no:2020QNRC001)。
Dear Editor,The case fatality rate of early SARS-CoV-2 infection is 3%(Ghebreyesus,2020),and the severe case rate is 24.3%(Sun et al.,2020).From the prototypic SARS-CoV-2 strain to the emergence of Alpha,Beta,and Delt...
关键词：NLRP3 branching ALPHA 
Gene therapy in advanced metachromatic leukodystrophy: tempering expectations
《Protein & Cell》2025年第1期12-15,共4页Daphne H.Schoenmakers Shanice Beerepoot Laura A.Adang Marije A.B.C.Asbreuk Caroline G.Bergner Annette E.Bley Jaap-Jan Boelens Valeria Calbi Alejandra Darling Erik Eklund Ángeles García Cazorla Sabine W.Grønborg Samuel Groeschel Peter M.van Hasselt Carla E.M.Hollak Claire Horgan Simon Jones Tom de Koning Lucia Laugwitz Caroline Lindemans Pascal Martin Fanny Mochel AndreasØberg Dipak Ram Caroline Sevin Ludger Schöls Ayelet Zerem Nicole I.Wolf Francesca Fumagalli 
Recently Zhang et al.(2024)published their study entitled“Lentivirus-modifed hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy:A long-term follow-up pilot study.”The...
关键词：DYSTROPHY al. STABILIZATION 
Lentivirus-modifed hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy:a long-term follow-up pilot study
《Protein & Cell》2025年第1期16-27,共12页Zhao Zhang Hua Jiang Li Huang Sixi Liu Xiaoya Zhou Yun Cai Ming Li Fei Gao Xiaoting Liang Kam-Sze Tsang Guangfu Chen Chui-Yan Ma Yuet-Hung Chai Hongsheng Liu Chen Yang Mo Yang Xiaoling Zhang Shuo Han Xin Du Ling Chen Wuh-Liang Hwu Jiacai Zhuo Qizhou Lian 
supported in part by Poland Fundacja Siepomaga,JS Foundation(Hong Kong),Shenzhen Li Weibo。
Metachromatic leukodystrophy(MLD)is an inherited disease caused by a defciency of the enzyme arylsulfatase A(ARSA).Lentivirus-modifed autologous hematopoietic stem cell gene therapy(HSCGT)has recently been approved fo...
关键词：HSCGT advanced symptomatic metachromatic leukodystrophy JUVENILE patients safety effcacy 
Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice
《Protein & Cell》2025年第1期28-48,共21页Sipeng Wu Yiqi Cai Lixiao Zhang Xiang Li Xu Liu Guangkeng Zhou Hongdi Luo Renjian Li Yujia Huo Zhirong Zhang Siyi Chen Jinliang Huang Jiahao Shi Shanwei Ding Zhe Sun Zizhuo Zhou Pengcheng Wang Geng Wang 
supported by the Priority Research Program of the Ministry of Science and Technology of the People’s Republic of China(Grant Nos.2017YFA0504600);the National Natural Science Foundation of the People’s Republic of China(Grants Nos.91649103,32091159).
One of the basic questions in the aging field is whether there is a fundamental difference between the aging of lower invertebrates and mammals.A major difference between the lower invertebrates and mammals is the abu...
关键词：TERC-53 mitochondrial noncoding RNAs brain aging NEUROINFLAMMATION UBIQUITINATION 
PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression
《Protein & Cell》2025年第1期49-63,共15页Zetan Jiang Nanchi Xiong Ronghui Yan Shi-ting Li Haiying Liu Qiankun Mao Yuchen Sun Shengqi Shen Ling Ye Ping Gao Pinggen Zhang Weidong Jia Huafeng Zhang 
supported in part by National Natural Science Foundation of China(Grant Nos.81930083,82192893,81821001,and 82303217);National Key R&D Program of China(2022YFA1304504);the Chinese Academy of Sciences(XDB39000000);the Global Select Project(DJK-LX-2022001)of the Institute of Health and Medicine;Hefei Comprehensive National Science Center and the Fundamental Research Funds for the Central Universities(WK9100000051).
Deactivation of the mitochondrial pyruvate dehydrogenase complex(PDC)is important for the metabolic switching of cancer cell from oxidative phosphorylation to aerobic glycolysis.Studies examining PDC activity regulati...
关键词：ACETYLATION lactylation liver cancer PDC PDHX 
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