《Protein & Cell》

作品数：1596被引量：7153H指数：32
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《Protein & Cell》
主办单位：Higher Education Press;Biophysical Society of China
最新期次：2025年3期更多>>
发文主题：CRYSTAL_STRUCTUREHUMANPIONEERCANCERAGING更多>>
发文领域：生物学医药卫生农业科学理学更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>
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SMURF1:a promising target for colon cancer therapy
《Protein & Cell》2025年第3期157-160,共4页Xiufang Xiong Yongchao Zhao Yi Sun 
supported by the National Key Research and Development Program of China(2022YFC3401500 to Y.Z.and Y.S.,2021YFA1101000 to Y.S.);the National Natural Science Foundation of China(32471300,92053117,and 81972591 to Y.Z.,92253203 and U22A20317 to Y.S.,81974429 and 82172898 to X.X.);the Natural Science Foundation of Zhejiang Province(LZ22H160003 to Y.Z.,LD22H300003 to Y.S.);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2022R01002 to Y.S.).
SMURF1(Smad ubiquitination regulatory factor 1),a HECT-type E3 ubiquitin ligase,plays pivotal regulatory roles in numerous biological processes,encompassing apoptosis,senescence,cell cycle progression,metastasis,and g...
关键词：genomic stabilityby colon cancer therapy ubiquitin ligaseplays smurf hect type e ubiquitin ligase signaling regulatory proteins APOPTOSIS biological processesencompassing 
Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens
《Protein & Cell》2025年第3期161-187,共27页Chao Yang Longfeng Yao Dan Chen Changling Chen Wenbo Li Hua Tong Zihang Cheng Yanling Yan Long Lin Jing Zhang Anbing Shi 
The National Key R&D Program of China(2021YFA1300302);the National Natural Science Foundation of China(32320103007,32130027);the National Science Fund for Distinguished Young Scholars(31825017);the Major Research Plan of the Natural Science Foundation of China(92154001)to A.Shi.
Endosomes are characterized by the presence of various phosphoinositides that are essential for defining the membrane properties.However,the interplay between endosomal phosphoinositides metabolism and innate immunity...
关键词：C.elegans RAB-10/Rab10 UNC-16/JIP3 sorting endosome EGL-8/PLC-β NHR-25/NR5A1/2 PI(4 5)P2 
IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses
《Protein & Cell》2025年第3期188-210,共23页Xinmin Qian Meiyi Tong Tianqing Zhang Qingqing Li Meng Hua Nan Zhou Wenwen Zeng 
supported by the National Key R&D Program of China(2023YFC2306300);the National Natural Science Foundation of China(Grant Nos.32225019,92357304,and 32394003);supported by the Center for Life Sciences,the Institute for Immunology,and School of Basic Medical Sciences at Tsinghua University.
Atopic dermatitis(AD)is a prevalent inflammatory skin disorder in which patients experience recurrent eczematous lesions and intense itching.The colonization of Staphylococcus aureus(S.aureus)is correlated with the se...
关键词：IL-24 atopic dermatitis MRSA KERATINOCYTES allergic inflammation 
High-throughput single-microbe RNA sequencing reveals adaptive state heterogeneity and host-phage activity associations in human gut microbiome
《Protein & Cell》2025年第3期211-226,共16页Yifei Shen Qinghong Qian Liguo Ding Wenxin Qu Tianyu Zhang Mengdi Song Yingjuan Huang Mengting Wang Ziye Xu Jiaye Chen Ling Dong Hongyu Chen Enhui Shen Shufa Zheng Yu Chen Jiong Liu Longjiang Fan Yongcheng Wang 
supported by the National Natural Science Foundation of China(No.32200073 and 32250710678,Y.W.);Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2021R01012,Y.W.);“Pioneer”R&D programs of Zhejiang Province(No.2024C03005,Y.W.);Key R&D Program of Zhejiang(No.2024SSYS0022,Y.W.).
Microbial communities such as those residing in the human gut are highly diverse and complex,and many with important implications for health and diseases.The effects and functions of these microbial communities are de...
关键词：single-microbe RNA sequencing(smRNA-seq) droplet microfluidics MICROBIOME host-phage association smRandom-seq2 
A novel loop-structure-based bispecific CAR that targets CD19 and CD22 with enhanced therapeutic efficacy against B-cell malignancies
《Protein & Cell》2025年第3期227-232,共6页Lijun Zhao Shuhong Li Xiaoyi Wei Xuexiu Qi Qiaoru Guo Licai Shi Ji-Shuai Zhang Jun Li Ze-Lin Liu Zhi Guo Hongyu Zhang Jia Feng Yuanyuan Shi Suping Zhang Yu J.Cao 
supported by the National Key R&D Program of China(2019YFA0906100 and 2019YFA0904200 to Y.J.C.);the Shenzhen Science and Technology Innovation Program(JCYJ20180504165501371 to Y.J.C.);the National Natural Science Foundation of China(32171464 and 81872783 to Y.J.C.),the Prevention and Control of COVID-2019 Research Program in University of Guangdong Province(2020KZDZX1176 to S.Z.);the Shenzhen Basic Research Program(JCYJ20180507182203049 to S.Z.);the Shenzhen Key Laboratory Foundation(ZDSYS20200811143757022 to S.Z.).
Dear Editor,Chimeric antigen receptor T(CAR-T)cells have achieved substantial advances in the treatment of B-cell malignancies.Despite high initial response rates,some patients relapse,characterized by targeted antige...
关键词：B cell malignancies therapeutic efficacy targeted antigen loss shalabi bispecific CAR T cells CD 
Cas7 meets Cas14:a strategic partnership in the typeⅦCRISPR-Cas
《Protein & Cell》2025年第2期79-82,共4页Yao Liu Senfeng Zhang Chunyi Hu 
National University of Singapore Presidential Young Professorship(PYP):23-0178-A0001;Singapore Ministry of Education Tier 1 grant:23-1065-P0001。
CRISPR(clustered regularly interspaced short palindromic repeats)-Cas systems,fundamental to prokaryotic adaptive immunity,are divided into two major classes based on their effector protein composition.Class 1 systems...
关键词：CRISPR COMPOSITION utilize 
Alzheimer's disease:insights into pathology,molecular mechanisms,and therapy
《Protein & Cell》2025年第2期83-120,共38页Qiuyang Zheng Xin Wang 
supported by the National Key R&D Program of China(2021ZD0202402 and 2021YFA1101401 to X.W.);the National Natural Science Foundation of China(82325018 and U21A20358 to X.W.,82271451 to Q.Z.);the Natural Science Foundation of Fujian Province of China(2021J02004 to X.W.);the Guangdong Basic and Applied Basic Research Foundation(2021B1515120081 to X.W.);the Fundamental Research Funds for the Chinese Central Universities(20720230070 to X.W.and Q.Z.,20720220052 to Q.Z.)。
Alzheimer's disease(AD),the leading cause of dementia,is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain.This condition casts a significant shadow on global health due to ...
关键词：Alzheimer's disease PATHOPHYSIOLOGY risk factors biomarkers prevention 
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune
《Protein & Cell》2025年第2期121-135,共15页Mei-Mei Zhao Ting-Ting Ren Jing-Kang Wang Lu Yao Ting-Ting Liu Ji-Chao Zhang Yang Liu Lan Yuan Dan Liu Jiu-Hui Xu Peng-Fei Tu Xiao-Dong Tang Ke-Wu Zeng 
financially supported by National Natural Sciences Foundation of China(82325050);National Key R&D Program of China(2022YFC3501601);Beijing Municipal Natural Science Foundation(7232273);Jinan New 20 Policies for Higher Education Funding(202228048);Natural Science Foundation of Shandong Province(Joint Foundation for Innovation and Development)(ZR2022LZY021)。
Pyroptosis is an identified programmed cell death that has been highly linked to endoplasmic reticulum(ER)dynamics.However,the crucial proteins for modulating dynamic ER membrane curvature change that trigger pyroptos...
关键词：PYROPTOSIS ER membrane antitumor immune OSTEOSARCOMA chemical degrader reticulon-4(RTN4) 
RADICAL:a rationally designed ion channel activated by ligand for chemogenetics
《Protein & Cell》2025年第2期136-142,共7页Heng Zhang Zhiwei Zheng Xiaoying Chen Lizhen Xu Chen Guo Jiawei Wang Yihui Cui Fan Yang 
supported by funding from the National Natural Science Foundation of China(32122040 and 31971040 to F.Y.;32071017 and 31922031 to Y.C.);Zhejiang Provincial Natural Science Foundation of China(LR20C050002 to F.Y.);China Postdoctoral Program for Innovative Talents(BX20230323 to H.Z.);China Postdoctoral Science Foundation(2024M752858 to H.Z.);The Fundamental Research Funds for the Central Universities(226-2022-00227 to F.Y.;226-2022-00149 to Y.C.);Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(NYKFKT2019001 to Y.C.);The Fundamental Research Funds for the Central Universities(226-2022-00227 to F.Y.)。
Dear Editor,Manipulating neuronal activities by exogenous means is always much desired in the field of neuroscience and beyond.Though many optogenetics and chemogenetics tools,such as channelrhodopsins and DREADDs(Arm...
关键词：RATIONAL CHANNEL LIMITATIONS 
Antiviral activity of lipoxygenase against severe fever with thrombocytopenia syndrome virus
《Protein & Cell》2025年第2期143-147,共5页Shuang Li Xiaojie Zheng Yunfa Zhang Lingyu Zhang Tong Yang Hao Li Caiyu Zhou Xiao-Ai Zhang Li-Zeng Gao Wei Liu 
supported by the National Natural Science Foundation of China(22121003)。
Dear Editor,Severe fever with thrombocytopenia syndrome(SFTS)is an emerging tick-borne infectious disease caused by Dabie bandavirus,also known as SFTS virus(SFTSV),a novel phlebovirus in the family Phenuiviridae of t...
关键词：FEVER THROMBOCYTOPENIA 
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