《Signal Transduction and Targeted Therapy》

作品数：2157被引量：9532H指数：41
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《Signal Transduction and Targeted Therapy》
主办单位：West China Hospital， Sichuan University
最新期次：2025年1期更多>>
发文主题：SARS-COVIMMUNITYCANCERDISEASESDRUGS更多>>
发文领域：医药卫生生物学文化科学理学更多>>
发文基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane
《Signal Transduction and Targeted Therapy》2025年第1期420-433,共14页Shulei Yin Yijie Tao Tianliang Li Chunzhen Li Yani Cui Yunyan Zhang Shenhui Yin Liyuan Zhao Panpan Hu Likun Cui Yunyang Wu Yixian He Shu Yu Jie Chen Shaoteng Lu Guifang Qiu Mengqi Song Qianshan Hou Cheng Qian Zui Zou Sheng Xu Yizhi Yu 
Metabolic reprogramming of host cells plays critical roles during viral infection.Itaconate,a metabolite produced from cis-aconitate in the tricarboxylic acid cycle(TCA)by immune responsive gene 1(IRG1),is involved in...
关键词：INVOLVEMENT GDI retaining 
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE
《Signal Transduction and Targeted Therapy》2025年第1期434-445,共12页Wen Qiao Chongrong Shen Yujiao Chen Shenghai Chang Xin Wang Lili Yang Jie Pang Qinghua Luo Zhibo Zhang Yingxin Xiang Chao Zhao Guangwen Lu Bi-Sen Ding Binwu Ying Xiaodi Tang Haohao Dong 
supported by the National Key Research and Development Program of China(2021YFA1301900 to H.D.);the National Natural Science Foundation of China(31900039 and 32170029 to X.T.,32000844 to S.C.,81971974 and 82372297 to H.D.);the 1.3.5 Project for Disciplines Excellence of West China Hospital,Sichuan University(ZYYC23014 to H.D.);the Sichuan Provincial Natural Science Foundation Outstanding Young Scientist Fund Project(2024NSFJQ0002 to H.D.).
Outer membrane(OM)lipoproteins serve vital roles in Gram-negative bacteria,contributing to their pathogenicity and drug resistance.For these lipoproteins to function,they must be transported from the inner membrane(IM...
关键词：FUNCTIONS OUTSIDE CHAINS 
Malate initiates a proton-sensing pathway essential for pH regulation of inflammation
《Signal Transduction and Targeted Therapy》2025年第1期446-470,共25页Yu-jia-nan Chen Rong-chen Shi Yuan-cai Xiang Li Fan Hong Tang Gang He Mei Zhou Xin-zhe Feng Jin-dong Tan Pan Huang Xiao Ye Kun Zhao Wen-yu Fu Liu-li Li Xu-ting Bian Huan Chen Feng Wang Teng Wang Chen-ke Zhang Bing-hua Zhou Wan Chen Tao-tao Liang Jing-tong Lv Xia Kang You-xing Shi Ellen Kim Yin-hua Qin Aubryanna Hettinghouse Kai-di Wang Xiang-li Zhao Ming-yu Yang Yu-zhen Tang Hai-long Piao Lin Guo Chuan-ju Liu Hong-ming Miao Kang-lai Tang 
supported by grants from the National Natural Science Foundation of China 82130071,82072516(Kanglai Tang);Sports Injury Repair and Reconstruction Research Innovative Team 41CZDH,Personalized Training Program of Leading Talent Training Object 414ZB2(Kanglai Tang);National Key R&D Program of China 2021YFC2401300(Lin Guo);National Natural Science Foundation of China 82173134(Hongming Miao);The Funding of Jinfeng Laboratory and Chongqing Outstanding Youth Fund CSTB2022NSCQ-JQX0010(Hongming Miao);NIH research grants R01AR062207,R01AR061484,R01AR076900,R01NS103931(Chuanju Liu);NIH research grants 1S10OD010582-01A1(Beatrix Ueberheide).
Metabolites can double as a signaling modality that initiates physiological adaptations.Metabolism,a chemical language encoding biological information,has been recognized as a powerful principle directing inflammatory...
关键词：interaction restrained ANALOGUES 
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis
《Signal Transduction and Targeted Therapy》2025年第1期471-472,共2页Han Yan Wenjun Liu Rui Xiang Xin Li Song Hou Luzheng Xu Lin Wang Dong Zhao Xingkai Liu Guoqing Wang Yujing Chi Jichun Yang 
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-024-01914-0,published online 08 August 2024 In the process of collating the raw data,the authors noticed one inadvertent mistake in...
关键词：HEPATIC CORRECTION repeatedly 
Correction: Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates
《Signal Transduction and Targeted Therapy》2025年第1期473-474,共2页Leonie Mayer Leonie M.Weskamm Marylyn M.Addo 
Correction to:Signal Transduction and Targeted Therapy(2024)9:327;https://doi.org/10.1038/s41392-024-02058-x;Article published online 20 November 2024 After the online publication of the research highlight,1 a reader ...
关键词：PRIMATES MODIFIED pointed 
Correction: SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice
《Signal Transduction and Targeted Therapy》2025年第1期475-475,共1页Wen Liu Meijing Wang Lihong Shen Yuyu Zhu Hongyue Ma Bo Liu Liang Ouyang Wenjie Guo Qiang Xu Yang Sun 
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-021-00474-x,published online 29 January 2021 In the process of collating the raw data,the authors noticed an inadvertent mistakes o...
关键词：LOVASTATIN SHP2 BOOST 
Inside help for brain tumors: macrophage-mediated myelin recycling promotes cell state-specific glioblastoma progression
《Signal Transduction and Targeted Therapy》2025年第1期1-2,共2页Antonio C.Pagano Zottola Thomas Daubon Varun Venkataramani 
In a recent paper published in Cell, Kloosterman et al. uncovered how lipid-laden macrophages in brain tumor called glioblastomas engage in myelin recycling, demonstrating that these cells process myelin debris into l...
关键词：MYELIN CD36 GLIOBLASTOMA 
Integration of novel biomarkers in prospective trials: biological insights from CHOICE-01
《Signal Transduction and Targeted Therapy》2025年第1期3-4,共2页Edward Christopher Dee Puneeth Iyengar 
The recent publication of the CHOICE-01 study,reporting overall survival(OS)and published in Signal Transduction and Targeted Therapy,1 recapitulated findings from an earlier publication of the trial.2 The CHOICE-01 i...
关键词：PROSPECTIVE CHEMOTHERAPY LUNG 
Cellular pathophysiology of Duchenne muscular dystrophy: insights from a novel rhesus macaque model
《Signal Transduction and Targeted Therapy》2025年第1期5-6,共2页Alessandra Moretti Christian Kupatt Eckhard Wolf 
supported by the ForTra gGmbH für Forschungstransfer der EKFS(2018_T20;2022_EKSE.41);A.M.and C.K.by the European Research Council(ERC,101141820 and 101021043);E.W.by the Leducq Foundation(Network 23CVD01).
In a recent study published in Cell,Ren and colleagues1 present a new rhesus macaque(Macaca mulatta)model for Duchenne muscular dystrophy(DMD)and a comprehensive single-cell analysis of skeletal muscle,providing detai...
关键词：DYSTROPHY DUCHENNE MUSCULAR 
Bridge over troubled cells: bone marrow stromal cells transfer mitochondria to boost T cells
《Signal Transduction and Targeted Therapy》2025年第1期7-9,共3页Lars Fabian Prinz Roland Tillmann Ullrich Markus Martin Chmielewski 
supported by Deutsche Forschungsgemeinschaft grant 455784452 as part of SFB 1530 project B05 to L.F.P.,R.T.U and M.M.C.;DFG grant 435414693 to M.M.C.M.M.C is further supported by Köln Fortune project 87/2023 and 124/2023.
In an article published in Cell in September 2024,Baldwin and colleagues present a bone marrow stromal cell(BMSC)based mitochondrial transfer platform to combat mitochondrial dysfunction or scarcity in human T cells e...
关键词：MARROW bone TRANSFER 
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