《Asian Journal of Pharmaceutical Sciences》

作品数：832被引量：1527H指数：13
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《Asian Journal of Pharmaceutical Sciences》
主办单位：沈阳药科大学
最新期次：2024年6期更多>>
发文主题：DRUGPHARMACOKINETICSBIOAVAILABILITYDISSOLUTIONNANOPARTICLES更多>>
发文领域：医药卫生理学化学工程一般工业技术更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金高等学校学科创新引智计划更多>>
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Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury
《Asian Journal of Pharmaceutical Sciences》2024年第6期1-20,共20页Weihang Zhou Xinchi Jiang Jianqing Gao 
This work was supported by the National Natural Science Foundation of China(U22A20383,82003668);the Natural Science Foundation of Zhejiang Province(LD22H300002,LQ21H300002);Ningbo Technology Innovation 2025 Major Special Project(2022Z150).
Ischemia/reperfusion(I/R)injury ismarked by the restriction and subsequent restoration of blood supply to an organ.This process can exacerbate the initial tissue damage,leading to further disorders,disability,and even...
关键词：Extracellular vesicles Extracellular vesicle engineering Ischemia/reperfusion injury NANOCARRIER Drug delivery 
Insights into microscopic fabrication, macroscopic forms and biomedical applications of alginate composite gel containing metal-organic frameworks
《Asian Journal of Pharmaceutical Sciences》2024年第6期21-47,共27页Yuanke Zhang Lvyao Yang Min Zhou Yanhua Mou Dongmei Wang Peng Zhang 
Overcoming the poor physicochemical properties of pure alginate gel and the inherent shortcomings of pure metal-organic framework(MOF),alginate/MOF composite gel has captured the interest of many researchers as a tuna...
关键词：ALGINATE Metal-organic framework(MOF) In-situ generation Chelation mechanism BIOMEDICINE 
Biopharmaceutical and pharmacokinetic attributes to drive nanoformulations of small molecule tyrosine kinase inhibitors
《Asian Journal of Pharmaceutical Sciences》2024年第6期48-83,共36页Soumyadip Mukherjee Vedant Joshi Kolimi Prashanth Reddy Nidhi Singh Priyanka Das Pallab Datta 
Buoyed by the discovery of small-molecule tyrosine kinase inhibitors(smTKIs),significant impact has been made in cancer chemotherapeutics.However,some of these agents still encounter off-target toxicities and suboptim...
关键词：PHARMACOKINETICS Tyrosine kinase inhibitors NANOPARTICLES Liposomes Peak plasma concentration 
Alkyl chain length-regulated in situ intelligent nano-assemblies with AIE-active photosensitizers for photodynamic cancer therapy
《Asian Journal of Pharmaceutical Sciences》2024年第6期84-100,共17页Lingyi Shen Qilong Zhang Yongchao Yao Yali Huang Zhichang Zheng Ming Li Hong Xu Lin Tan Xukun Liao Binyi Xia Lin Li Carl Redshaw Yang Bai Chengli Yang 
supported by the National Natural Science Foundation of China (81860543,32360237);Guizhou Provincial Science and Technology Projects (ZK[2023];Key Project 041,ZK[2021]076,[2019]2792 and[2018]5779-14);Guizhou Provincial Department of Education Foundation (KY[2022]229);Cultivation program of the Affiliated Hospital of Guizhou Medical University (gyfynsfc-2022-39);Cultivation program of the Guizhou Medical University (20NSP012);CR thanks the University of Hull for support
Photodynamic therapy(PDT)brings new hope for the treatment of breast cancer due to few side effects and highly effective cell killing;however,the low bioavailability of traditional photosensitizers(PSs)and their depen...
关键词：Aggregation-induced emission PHOTOSENSITIZERS Photodynamic therapy ROS generation Self-assembled nanoparticles 
A new nano approach to prevent tumor growth in the local treatment of glioblastoma: Temozolomide and rutin-loaded hybrid layered composite nanofiber
《Asian Journal of Pharmaceutical Sciences》2024年第6期101-122,共22页Melis Ercelik Cagla Tekin Melisa Gurbuz Yagmur Tuncbilekli Hazal Yılmaz Dogan Busra Mutlu Pınar Eser Gulcin Tezcan Fatma Nur Parın Kenan Yildirim Mehmet Sarihan Gurler Akpinar Murat Kasap Ahmet Bekar Hasan Kocaeli Mevlut Ozgur Taskapilioglu Secil Ak Aksoy Rıfat Ozpar Bahattin Hakyemez Berrin Tunca 
This study was supported by Scientific and Technological Research Council of Turkey(TUBITAK)under the Grant Number 121S624.
Total resection of glioblastoma(GB)tumors is nearly impossible,and systemic administration of temozolomide(TMZ)is often inadequate.This study presents a hybrid layered composite nanofiber network(LHN)designed for loca...
关键词：GLIOBLASTOMA Local treatment TEMOZOLOMIDE RUTIN Hybrid layered composite nanofiber network 
Cell membrane-coated mRNA nanoparticles for enhanced delivery to dendritic cells and immunotherapy
《Asian Journal of Pharmaceutical Sciences》2024年第6期123-137,共15页Qiaoyun Li Junho Byun Dongyoon Kim Yina Wu Jaiwoo Lee Yu-Kyoung Oh 
funded by grants from the National Research Foundation (NRF) of Korea,Ministry of Science and ICT,Republic of Korea (NRF-2021R1A2B5B03002123;NRF-2018R1A5A2024425;NRF-2022M3E5F1017919);the Alchemist Project of the Korea Evaluation Institute of Industrial Technology (KEIT 20018560,NTIS 1415184668)
Cationic polymers such as polyethylenimine have been considered promising carriers for mRNA vaccines.However,their application is hindered by their inherent toxicity and a lack of targeted delivery capability.These is...
关键词：Cell membrane coating Dendritic cells mRNA delivery Immune response Antitumor effect 
CaCO_(3)-encircled hollow CuS nanovehicles to suppress cervical cancer through enhanced calcium overload-triggered mitochondria damage
《Asian Journal of Pharmaceutical Sciences》2024年第6期138-153,共16页Pengfei Wang Xichen Sun Liuyan Tang Ningning Li Qing Wang Bicheng Gan Yuezhou Zhang 
This research was sponsored by the key research program of Ningbo(No.2023Z210);funded by Ningbo Natural Science Foundation(No.202003N4006);the Joint Research Funds of Department of Science&Technology of Shaanxi Province,Northwestern Polytechnical University(No.2020GXLH-Z-017).
Cervical cancer stands is a formidablemalignancy that poses a significant threat towomen’s health.Calcium overload,a minimally invasive tumor treatment,aims to accumulate an excessive concentration of Ca^(2+)within m...
关键词：Hollow CuS nanovehicles Tumor-specific synergistic therapy Mitochondrial damage Cascade-enhanced calcium overload 
Structure based release kinetics analysis of doxazosin mesylate sustained-release tablets using micro-computed tomography
《Asian Journal of Pharmaceutical Sciences》2024年第6期154-162,共9页Qian Liu Mengqing Zan Hanhan Huang Hai Su Wenjing Zhang Lingyun Ma Guangchao Zhang Zunjian Zhang Jiwen Zhang Jianzhao Niu Mingdi Xu 
This work was supported by the Key Programfor International Science and Technology Cooperation Projects of China(2020YFE0201700);State Drug Administration key laboratory project(2024HYZX04).
The structures of solid dosage forms determine their release behaviors and are critical attributes for the design and evaluation of the solid dosage forms.Here,the 3D structures of doxazosin mesylate sustained-release...
关键词：Doxazosin mesylate sustained-release tablets Osmotic pump tablets Micro-computed tomography Three-dimensional structures ETHANOL 
Improving treatment for Parkinson’s disease:Harnessing photothermal and phagocytosis-driven delivery of levodopa nanocarriers across the blood-brain barrier
《Asian Journal of Pharmaceutical Sciences》2024年第6期163-179,共17页Kaili Liang Li Yang Jiawei Kang Bo Liu Ding Zhang Liyan Wang Wei Wang Qing Wang 
Parkinson’s disease(PD)poses a significant therapeutic challenge,mainly due to the limited ability of drugs to cross the blood-brain barrier(BBB)without undergoing metabolic transformations.Levodopa,a key component o...
关键词：LEVODOPA Oxidative stress Blood-brain barrier Photothermal effect PHAGOCYTOSIS 
Metal-organic frameworks in oral drug delivery
《Asian Journal of Pharmaceutical Sciences》2024年第5期1-27,共27页Aun Raza Wei Wu 
Metal-organic frameworks(MOFs)offer innovative solutions to the limitations of traditional oral drug delivery systems through their unique combination of metal ions and organic ligands.This review systematically exami...
关键词：Metal-organic frameworks Drug delivery ORAL BIOAVAILABILITY NANOTECHNOLOGY 
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