《Open Journal of Medicinal Chemistry》

作品数：82被引量：26H指数：2
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《Open Journal of Medicinal Chemistry》
主办单位：美国科研出版社
最新期次：2024年4期更多>>
发文主题：DERIVATIVESLTANTICANCERIANTI-INFLAMMATORY更多>>
发文领域：医药卫生理学经济管理金属学及工艺更多>>
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Assay Advancements: Exploring Varied Assays for Thyroid-Stimulating Hormone Measurement in Subclinical Hypothyroidism Diagnosis in Riyadh, Saudi Arabia
《Open Journal of Medicinal Chemistry》2024年第4期45-56,共12页Qumasha Alobaid Sumayah Aljenedil Waleed Altamimi Khalid Alsumaily 
Thyroid-stimulating hormone (TSH) assay is considered a decisive diagnostic method for thyroid disorders. The lack of different TSH immunoassay standardization often leads to misdiagnosis of subclinical hypothyroidism...
关键词：Immunoassays Subclinical Hypothyroidism Thyroid Stimulating Hormone 
Comprehensive Assessment of Anxiolytic Properties in 4-HPAA Derivatives: Bridging in Vivo Validation and Molecular Docking Analyses
《Open Journal of Medicinal Chemistry》2024年第3期29-44,共16页Kawthar Alhussieni Rami Ayoub Jamal Jilani Qais Jarrar Othman Alhussinei Vetriselvan Subramaniyan Esra Nasraldin Khalil Sharafaldin Harshini Muruganantham Jureerat Kijsomporn Ling Shing Wong 
Anxiety is a significant mental health issue that substantially affects an individual’s quality of life. Feelings of uneasiness, irritability, and sleep disturbances characterize it. 4-Hydroxyphenyl acetic acid (4-HP...
关键词：ANXIOLYTICS 4-HPAA Molecular Docking Elevated Plus-Maze Zero Maze Tests 
Preparation and Characterization of Vitamin-D Incorporated Marshmallow
《Open Journal of Medicinal Chemistry》2024年第2期15-28,共14页Muhammad Ajmal Rubina Bibi Rauf Imran Muhammad Ahmed Bin Azher 
This project looks at a novel way to enhance the sensory experience of vitamin D ingestion by incorporating it into marshmallows. This investigation used a human panel taste test with twelve individuals, an index of s...
关键词：Vitamin D Marshmellow Infusion Taste Making Supplement Adherence Nutrient Delivery 
Synthesis and Physico-Chemical Characterizations of Novel Hydrazone Ligands and Their Metal Complexes against Hormone-Dependent and Independent Cancers
《Open Journal of Medicinal Chemistry》2024年第1期1-12,共12页Sommai Patitungkho Kingkaew Patitungkho 
This work deals with the synthesis and physicochemical characterizations of a new group of novel retinoidal ligands and their metal complexes. Their in vitro anti-proliferative activities have shown that ligand L1 is ...
关键词：Metal Complexes CANCERS ANTIOXIDANT Hydrazone Retinoid Receptors 
Synthesis, SAR, and in Silico ADME Screening Studies of Some 9-Amino-3-Phenylacridone Derivatives as Topoisomerase II Inhibitors
《Open Journal of Medicinal Chemistry》2023年第2期15-34,共20页Abiodun S. Oyedele Toluwase H. Fatoki Esha Dalvie Neil Osheroff Cosmas O. Okoro 
Cancer is a leading cause of death globally, claiming about 9.6 million lives and approximately 420 million new cases of cancer will be diagnosed in the world by the year 2025. The aim of this study was to synthesize ...
关键词：CANCERS 9-Aminoacridone ANTICANCER Topoisomerase II PHARMACOKINETICS Molecular Docking ETOPOSIDE 
Physicochemical Properties and Biological Activities of Novel Hydrazonate Copper Complexes
《Open Journal of Medicinal Chemistry》2023年第1期1-13,共13页Sommai Patitungkho Kingkaew Patitungkho 
The objective of this research was to elucidate the biological effect of novel compounds derived from natural product of syringaldehyde through novel semi-synthetic method in order to investigate the physicochemical p...
关键词：Schiff Base Hydrazone Natural Product ANTICANCER ANTIBACTERIAL Anti-Free Radical 
Synthesis, Biological Evaluation, and SAR Studies of Varyingly Substituted 4-Thioflavonols
《Open Journal of Medicinal Chemistry》2022年第2期15-25,共11页Rubina Bibi Amina Sadiq Ehsan Ullah Mughal 
A series of 4-thioflavonols compounds were synthesized by treating flavonols with lawsons reagent with variable substituent groups at A, B, and AB rings. All the synthesized compounds were checked for antibacterial an...
关键词：FLAVONOLS 4-Thioflavonols FLAVONOIDS Lawsons Reagent Antibacterial Activity Antifungal Activity One Pot Synthesis Sulfur Compounds SAR Studies 
New Copper (II), Palladium (II), and Platinum (II) 2-Acetylpyrazine Tert-Butylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells
《Open Journal of Medicinal Chemistry》2022年第1期1-13,共13页Edward C. Lisic Sarah N. Grossarth Sarah B. Bowman Jessica L. Hill Michael W. Beck Joseph E. Deweese Xiaohua Jiang 
The new ligand, 2-acetylpyrazine-tertbutylthiosemicarbazone (APZ-tBTSC), and its Cu(II), Pd(II) and Pt(II) complexes have been synthesized. This ligand coordinates to the metal ions in a tridentate monoanionic fashion...
关键词：TOPOISOMERASE Breast Cancer α-(N)-Heterocyclic Thiosemicarbazones 
Anti-Melanogenesis Effect of Daniellic Acid Isolated from <i>Daniellia oliveri</i>(Rolfe) Hutch. &Dalziel (Leguminosae) Oleoresin of Burkina Faso
《Open Journal of Medicinal Chemistry》2021年第4期41-57,共17页Aminata P. Nacoulma Moussa Compaoré Naamwin-so-Bawfu Romaric Meda Laurent Pottier Véronique Megalizzi Issa Some Martin Kiendrebeogo 
Over the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, Danielli...
关键词：Daniellia oliveri Daniellic Acid Tyrosinase MELANOGENESIS Cytotoxicity 
Synthesis and Antibacterial Activities of New 2-(Benzylthio)pyrimidines and 2-(Benzimidazolylmethylthio)pyrimidines Derivatives
《Open Journal of Medicinal Chemistry》2021年第3期27-39,共13页Achi Patrick-Armand Coulibali Siomenan Zon Doumade Timotou Adéyolé Bolou Eric Touré Daouda Sissouma Drissa Adjou Ané 
A series of 2-(benzylthio)由于版权政策及相关保密法规原因，条结果未予显示。
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