《Cancer Drug Resistance》

作品数：425被引量：315H指数：6
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《Cancer Drug Resistance》
主办单位：OAE出版公司
最新期次：2024年1期更多>>
发文主题：DRUG_RESISTANCERESISTANCECANCERCHEMORESISTANCECHECKPOINT更多>>
发文领域：医药卫生理学文化科学一般工业技术更多>>
发文基金：国家自然科学基金重庆市自然科学基金更多>>
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Mechanisms of immunotherapy resistance in small cell lung cancer
《Cancer Drug Resistance》2024年第1期1-23,共23页Yunan Nie Kurt A.Schalper Anne Chiang 
Small-cell lung cancer(SCLC)is an aggressive neuroendocrine tumor with a poor prognosis.Although the addition of immunotherapy to chemotherapy has modestly improved outcomes,most patients rapidly develop resistance.Re...
关键词：Immunotherapy resistance small cell lung cancer BIOMARKER primary resistance acquired resistance 
Mitochondrial genome variability and metabolic alterations reveal new biomarkers of resistance in testicular germ cell tumors
《Cancer Drug Resistance》2024年第1期24-43,共20页Pavlina Kabelikova Danica Ivovic Zuzana Sumbalova Miloslav Karhanek Lucia Tatayova Martina Skopkova Michal Cagalinec Vladimira Bruderova Jan Roska Dana Jurkovicova 
supported by the VEGA Grant Agency of the Slovak Republic(grant no.2/0056/21);the Slovak Research and Development Agency(grant no.APVV-19-0286);Doctoral grant of the Slovak Academy of Sciences(grant no.APP0377).
Aim:Mutations in the mitochondrial(mt)genome contribute to metabolic dysfunction and their accumulation relates to disease progression and resistance development in cancer cells.This study explores the mutational stat...
关键词：Testicular cancer CHEMORESISTANCE MITOCHONDRIA mtDNA mutation OXPHOS GLYCOLYSIS 
Ovarian tumor microenvironment contributes to tumor progression and chemoresistance
《Cancer Drug Resistance》2024年第1期44-58,共15页Adriana Ponton-Almodovar Samuel Sanderson Ramandeep Rattan Jamie JBernard Sachi Horibata 
supported by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number(R01ES030695)(Bernard JJ);HFH+MSU Health Sciences(Horibata S,Bernard JJ,Rattan R),Michigan State University Startup Funds(Horibata S),and the Integrative Pharmacological Sciences Training Program(T32GM142521)(Ponton-Almodovar A).
Ovarian cancer is one of the deadliest gynecologic cancers affecting the female reproductive tract.This is largely attributed to frequent recurrence and development of resistance to the platinum-based drugs cisplatin ...
关键词：Ovarian cancer CHEMORESISTANCE tumor microenvironment 
Role of the TME in immune checkpoint blockade resistance of non-small cell lung cancer
《Cancer Drug Resistance》2024年第1期59-85,共27页Yuening Dai Xueqi Tian Xuanting Ye Yabin Gong Ling Xu Lijing Jiao 
supported by grants from the Ministry of Science and Technology,RPC(No.2023YFC3503302);the Shanghai Municipal Commission of Science and Technology(No.22Y31920400);the National Natural Science Foundation of China(No.82474484).
Primary and secondary resistance to immune checkpoint blockade(ICB)reduces its efficacy.The mechanisms underlying immunotherapy resistance are highly complex.In non-small cell lung cancer(NSCLC),these mechanisms are p...
关键词：Lung cancer tumor microenvironment immune checkpoint blockade RESISTANCE mechanism 
NFE2L2 and ferroptosis resistance in cancer therapy
《Cancer Drug Resistance》2024年第1期273-296,共24页Daolin Tang Rui Kang 
supported by grants from the National Institutes of Health of USA(R01CA160417,R01CA229275,and R01CA211070).
NFE2-like basic leucine zipper transcription factor 2(NFE2L2,also known as NRF2),is a key transcription factor in the cellular defense against oxidative stress,playing a crucial role in cancer cell survival and resist...
关键词：Cancer therapy drug resistance ferroptosis NFE2L2 oxidative stress 
The BET inhibitor sensitivity is associated with the expression level of CDC25B in pancreatic cancer models
《Cancer Drug Resistance》2024年第1期297-308,共12页Aubrey L.Miller Patrick L.Garcia Rebecca B.Vance Eric O.Heard Eric J.Brown Karina J.Yoon 
NIH grant R01CA208272(to Yoon KJ).
Aim:Cell division cycle 25B(CDC25B)belongs to the CDC25 family of phosphatases that regulate cell cycle progression.CDC25B also contributes to tumor initiation and progression,but no connection between CDC25B levels a...
关键词：Cell division cycle 25B(CDC25B) pancreatic ductal adenocarcinoma(PDAC) GEMCITABINE patient-derived xenograft(PDX)models BET inhibitor(BETi) gemcitabine-resistant(gemR)models 
Unlocking the potential of immunotherapy in platinum-resistant ovarian cancer:rationale,challenges,and novel strategies
《Cancer Drug Resistance》2024年第1期309-331,共23页Joanna Kefas Michael Flynn 
Ovarian cancer is a significant global health challenge,with cytoreductive surgery and platinum-based chemotherapy serving as established primary treatments.Unfortunately,most patients relapse and ultimately become pl...
关键词：Ovarian cancer IMMUNOTHERAPY immune checkpoint inhibition immunotherapy resistance 
Emerging roles of small extracellular vesicles in metabolic reprogramming and drug resistance in cancers
《Cancer Drug Resistance》2024年第1期332-356,共25页Jingcun Shi Ying Shen Jianjun Zhang 
supported by grants from the Project of the National Natural Science Foundation of China(grant No.82372871 and 82173148 to Zhang J).
Studies of carcinogenic metabolism have shown that cancer cells have significant metabolic adaptability and that their metabolic dynamics undergo extensive reprogramming,which is a fundamental feature of cancer.The Wa...
关键词：Small extracellular vesicles metabolic reprogramming drug resistance neoplasms GLYCOLYSIS lipid metabolism amino acid metabolism 
Competing endogenous RNAs(ceRNAs)and drug resistance to cancer therapy
《Cancer Drug Resistance》2024年第1期357-381,共25页Kenneth K.W.To Hang Zhang William C.Cho 
support provided by the Chinese University of Hong Kong(Direct Grant 4054782);Guangdong-Hong Kong-Macao New Drug Screening Joint Laboratory(Project 8326200);the SKL Open Fund(SKLOF-X)from the Institute of Chinese Medicine(CUHK).
Competing endogenous RNAs(ceRNAs)are transcripts that possess highly similar microRNA response elements(MREs).microRNAs(miRNAs)are short,endogenous,single-stranded non-coding RNAs(ncRNAs)that can repress gene expressi...
关键词：Alternative mRNA polyadenylation cancer immunotherapy ceRNA crosstalk immune evasion microRNA mRNA 3’untranslated region multidrug resistance non-coding RNA 
Screening of photosensitizers-ATP binding cassette(ABC)transporter interactions in vitro
《Cancer Drug Resistance》2024年第1期382-402,共21页Shruti Vig Payal Srivastava Idrisa Rahman Renee Jaranson Anika Dasgupta Robert Perttilä Petteri Uusimaa Huang-Chiao Huang 
support from the US NIH Trailblazer Award(NIBIB R21EB028508);US National Science Foundation(CBET-2030253,CBET-2037815);the US NIH(R01CA260340,R01CA256710);Modulight Corporation;I.R.is supported by the NCI-UMD partnership for integrative cancer research fellowship;Rahman I and Dasgupta A are supported by the University of Maryland ASPIRE Fellowship;Vig S is supported by the MPower Fellowship.
Aim:ATP-binding cassette(ABC)transporters are proteins responsible for the efflux of drug molecules from cancer cells,reducing the efficacy of anti-cancer treatments.This study assesses the susceptibility of a panel o...
关键词：Multidrug resistance ATP-binding cassette(ABC)transporters PHOTOSENSITIZERS photodynamic therapy 
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