《Oncology Research》

作品数：323被引量：132H指数：4
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《Oncology Research》
主办单位：Tech Science Press
最新期次：2025年1期更多>>
发文主题：RETRACTIONPROMOTESPROGRESSIONINVASIONPROLIFERATION更多>>
发文领域：医药卫生文化科学生物学自动化与计算机技术更多>>
发文基金：国家自然科学基金广东省自然科学基金重庆市自然科学基金北京市自然科学基金更多>>
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Engendered nanoparticles for treatment of brain tumors
《Oncology Research》2025年第1期15-26,共12页SOROUSH SOLEYMANI MOHAMMAD DOROUDIAN MAHDIEH SOEZI ALI BELADI KIARASH ASGARI ASO MOBARAKSHAHI ARYANA AGHAEIPOUR RONAN MACLOUGHLIN 
Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors.Its median survival time is typically less than a year after diagnosis.One of the major challenges in tr...
关键词：NANOPARTICLES Smart nanoparticles Stimuli responsive nanoparticles Targeted nanoparticles Blood-brain barrier(BBB) Brain cancer 
Research advancements in nanoparticles and cell-based drug delivery systems for the targeted killing of cancer cells
《Oncology Research》2025年第1期27-44,共18页MERYEM A.ABDESSALEM SIRIN A.ADHAM 
Nanotechnology in cancer therapy has significantly advanced treatment precision,effectiveness,and safety,improving patient outcomes and personalized care.Engineered smart nanoparticles and cell-based therapies are des...
关键词：Drug delivery Cancer NANOPARTICLES Liposomes Micelles Combination therapies Targeted therapy Precision medicine Tumor microenvironment(TME) 
Genetic signatures of ERCC1 and ERCC2 expression,along with SNPs variants,unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy
《Oncology Research》2025年第1期45-55,共11页ENRICO CALIMAN SARA FANCELLI FEDERICO SCOLARI ADRIANO PASQUI CLARA MANNESCHI DANIELE LAVACCHI FRANCESCA MAZZONI FRANCESCA GENSINI VALERIA PASINI CAMILLA EVA COMIN LUCA VOLTOLINI SERENA PILLOZZI LORENZO ANTONUZZO 
Background:Platinum chemotherapy(CT)remains the backbone of systemic therapy for patients with smallcell lung cancer(SCLC).The nucleotide excision repair(NER)pathway plays a central role in the repair of the DNA damag...
关键词：Small cell lung cancer(SCLC) Nucleotide excision repair(NER)pathway ERCC genes Single nucleotide polymorphisms(SNPs) Platinumchemotherapy(CT) 
Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab
《Oncology Research》2025年第1期57-65,共9页RYUL KIM JOO KYUNG PARK MINSUK KWON MINAE AN JUNG YONG HONG JOON OH PARK SUNG HEE LIM SEUNG TAE KIM 
supported by the MISP program at Merck Sharp&Dohme Corp.,USA;a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI);funded by the Ministry of Health&Welfare,Republic of Korea(Grant Number:HR20C0025).
Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid tumors.However,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still controversial...
关键词：Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer 
Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer
《Oncology Research》2025年第1期67-81,共15页XIANG LI WENKE JIN LIFENG WU HUAN WANG XIN XIE WEI HUANG BO LIU 
the National Natural Science Foundation of China(Nos.22307009,82374155,82073997,82104376);the Sichuan Science and Technology Program(Nos.2023NSFSC1108,2024NSFTD0023);the Postdoctoral Research Project of Sichuan Province;the Xinglin Scholar Research Promotion Project of Chengdu University of TCM.
Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional therapies.Autoph...
关键词：Triple-negative breast cancer(TNBC) AUTOPHAGY Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1 
HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation
《Oncology Research》2025年第1期83-102,共20页YUEZHOU ZHANG ZHAO ZHANG JINXIN DONG CHANGAN LIU 
Background:Aberrant expression of RNA-binding proteins(RBPs)has been linked to a variety of diseases,including hematological disorders,cardiovascular diseases,and multiple types of cancer.Heterogeneous nuclear ribonuc...
关键词：Heterogeneous nuclear ribonucleoprotein C(HNRNPC) Pan-cancer analysis Tumor immunity Prognostic biomarker Immunotherapeutic target Hepatocellular carcinoma 
Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3
《Oncology Research》2025年第1期103-121,共19页YAN LU KANG WANG YUANHONG PENG MENG CHEN LIN ZHONG LUJI HUANG FU CHENG XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE 
funded by the Natural Science Foundation of Guangdong Province(grant number 2022A1515012315);Guangdong Medical Science and Technology Research Fund Project(grant number A2023185);the Discipline Construction Project of Guangdong Medical University(grant number 4SG22005G);the 2023 Provincial Basic and Applied Basic Research Fund Enterprise Joint Fund Project(grant number 2023A1515220149);Southern Medical University Shunde Hospital 2023 Research Initiation Programme Project(SRSP2023016).
Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-...
关键词：Breast cancer B7H3 Hsa-miR-214-3p IMMUNOTHERAPY 
STIL enhances the development of lung adenocarcinoma by regulating the glycolysis pathway
《Oncology Research》2025年第1期123-132,共10页LEI WANG XIANJIN XIE 
Background:To investigate SCL/TAL 1 interrupting locus(STIL)’s role and prognostic significance in lung adenocarcinoma(LUAD)progression,we examined STIL and E2 promoter binding factor 1(E2F1)expression and their impa...
关键词：SCL/TAL1 interrupting locus(STIL) Lung adenocarcinoma E2 promoter binding factor 1 GLYCOLYSIS 
CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway
《Oncology Research》2025年第1期133-148,共16页TAO SUN QINGHUA SONG HUA LIU 
Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in China.The crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent...
关键词：Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) EXOSOMES miR-3124-5p Toll-interacting protein(TOLLIP) 
The impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CTP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center
《Oncology Research》2025年第1期149-160,共12页NASSER MULLA YOUSEF KATIB ASIM M.ALMUGHAMSI DUAA S.ALKHAYAT MOHAMED MOSAAD SAMIR T.ALFOTIH RAWAN ALAOFI 
Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi Arabia.Our study aimed to investigate the patterns of HCC and the effect of TNM staging,Alfa-fetoprotein(AFP),and Child...
关键词：Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival 
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