DYSREGULATION

作品数：170被引量：528H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：杨燕青李亮廉哲雄姚远王菲菲更多>>
相关机构：中国科学技术大学山东中医药大学附属眼科医院第二军医大学徐州医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金泰国研究基金更多>>
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Selenium deficiency-induced multiple tissue damage with dysregulation of immune and redox homeostasis in broiler chicks under heat stress被引量：4
《Science China(Life Sciences)》2023年第9期2056-2069,共14页Ling Zhao Meng Liu Hua Sun Jia-Cheng Yang Yu-Xuan Huang Jia-Qiang Huang Xingen Lei Lv-Hui Sun 
supported by the National Natural Science Foundation of China (32102588);the Top-notch Young Talent Supporting Program to LHS;Beijing Deyuanshun Biological Technology Co.,Ltd。
Broiler chicks are fast-growing and susceptible to dietary selenium(Se) deficiency. This study sought to reveal the underlying mechanisms of how Se deficiency induces key organ dysfunctions in broilers. Day-old male c...
关键词：SELENIUM multiple tissue damage METABOLOME TRANSCRIPTOME BROILERS 
Aldosterone dysregulation predicts the risk of mortality and rehospitalization in heart failure with a preserved ejection fraction被引量：1
《Science China(Life Sciences)》2022年第3期631-642,共12页Bingbing Ke Xin Tan Lu Ren Yangkai Fan Yixin Zhang Fengjuan Li Qiqi Sun Tong Liu Lixin Jia Yuan Wang Jie Du 
supported by the National Key Research and Development Program of China(2017YFC0908400);the National Natural Science Foundation of China(91939303,81790622,81861128025)。
Serum aldosterone is associated with cardiac remodeling,which contributes to morbidity and mortality in heart failure(HF);however,the prognostic value of aldosterone in HF with a preserved ejection fraction(HFpEF)is u...
关键词：ALDOSTERONE concentric remodeling prognosis HFpEF liquid chromatography-tandem mass spectrometry 
Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets被引量：7
《Science China(Life Sciences)》2020年第4期469-484,共16页Yongbo Wang Yufang Bao Sirui Zhang Zefeng Wang 
supported by the National Natural Science Foundation of China (81871878 and 31371299 to Y.B.W.;31730110, 31661143031, and 31570823 to Z.F.W.);supported by the type A CAS Pioneer 100-Talent Program.
RNA splicing dysregulation is widespread in cancer. Accumulating evidence demonstrates that splicing defects resulting from splicing dysregulation play critical roles in cancer pathogenesis and can serve as new biomar...
关键词：SPLICING ALTERNATIVE SPLICING CANCER RNA THERAPEUTICS 
Epigenetic mechanism of Survivin dysregulation in human cancer被引量：13
《Science China(Life Sciences)》2018年第7期808-814,共7页Hui Lyu Jingcao Huang Zhimin He Bolin Liu 
supported by the National Institutes of Health/National Cancer Institute(NIH/NCI)(R01CA201011);the National Natural Science Foundation of China(81472763 to Bolin Liu)
Survivin(coding gene BIRC5) is a dual functional protein acting as a critical inhibitor of apoptosis(IAP) and key regulator of cell cycle progression. It is usually produced in embryonic tissues during development and...
关键词：SURVIVIN EPIGENETICS DNA methylation histone modification cancer therapy 
Early calcium dysregulation in Alzheimer's disease:setting the stage for synaptic dysfunction被引量：6
《Science China(Life Sciences)》2011年第8期752-762,共11页Shreaya CHAKROBORTY Grace E.STUTZMANN 
Alzheimer's disease(AD) is an irreversible and progressive neurodegenerative disorder with no known cure or clear understanding of the mechanisms involved in the disease process.Amyloid plaques,neurofibrillary tangles...
关键词：CALCIUM Alzheimer＇s NEURON synaptic dysfunction plasticity ER RYANODINE CICR 
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