云南高校图书馆联盟文献共享服务平台- RYANODINE

RYANODINE: 作品数：56被引量：93H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：朱培闳胡晓芳李智赵志奇张玉秋更多>>; 相关机构：中国科学院上海生命科学研究院复旦大学中国医科大学北京大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金上海市科学技术发展基金更多>>

Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy: 《Acta Pharmacologica Sinica》2020年第3期303-310,共8页Zhen-dong Xu Yong Wang Ge Liang Zhi-qiang Liu Wu-hua Ma Charleen T Chu Hua-feng Wei; Supported by grants to HW from the NIH(R01GM084979,3R01GM084979-02S1,and 2R01GM084979-06A1)and R01AG026389-10S1 to CTC;Supported by grants to ZX from Shanghai Municipal Health Bureau(201840149);Supported by grants to ZX from the National Natural Science Foundation of China(81971418);Supported by grants to YW from the National Natural Science Foundation of China(81503663).; Propofol is a commonly used intravenous anesthetic agent,which has been found to affect cell survival and proliferation especially in early life.Our previous studies show that propofol-induced neurodegeneration and ne...; 关键词：PROPOFOL AUTOPHAGY ATG5 CALCIUM lnsP3 RECEPTORS RYANODINE RECEPTORS mouse embryonic FIBROBLASTS

Ryanodine受体蛋白的分子结构和理化性质分析: 《生物学杂志》2019年第5期25-30,共6页杨越朱家佳唐乖龙鼎新; 国家自然科学基金(81673227;81172712);南华大学研究生科学基金项目(2018KYY220); Ryanodine受体(Ryanodine receptor, RyR)是一种重要的配体门控的Ca 2+通道,分析RyR蛋白的结构及其理化性质对了解其调控机制具有重要意义。运用生物信息学方法,对RyR 3种亚型蛋白进行了分子结构和理化性质分析。结果显示RyR 3种亚型均...; 关键词：RYANODINE受体生物信息学蛋白结构氨基酸

Synthesis and Bioactivities Evaluation of Novel Anthranilic Diamides Containing N-(tert-Butyl)benzohydrazide Moiety as Potent Ryanodine Receptor Activator被引量：1: 《Chinese Journal of Chemistry》2019年第6期605-610,共6页Yunyun Zhou Wei Wei Liangliang Zhu Yuxin Li; the NSFC/China (No.21502229);Tianjin Natural Science Foundation (No.16JCYBJC29400).; Anthranilic diamides have been proven to be a class of efficacious and safe insecticides targeting ryanodine receptors (RyRs) during the last decade. In order to develop innovative scaffolds with high insecticidal act...; 关键词：anthranilic diamides acylhydrazine HETEROCYCLES calcium channel STRUCTURE-ACTIVITY relationships INSECTICIDAL activities

Synthesis, bioactivity, action mode and 3D-QSAR of novel anthranilic diamide derivatives被引量：4: 《Chinese Chemical Letters》2019年第2期417-420,共4页Weijie Liu Jiao Li Kai He Fangfang Huang Yi Ma Yuxin Li Qingshan Li Fengbo Xu; supported by the National Natural Science Foundation of China(Nos. 20772060 and 21172114); To study the pesticide effect, action mode, structure-activity relationships (SARs) of anthranilic diamide insecticide and screen highly active pesticides, novel anthranilic diamide derivatives were synthesized.Bioass...; 关键词：Anthranilic DIAMIDE RYANODINE RECEPTOR INSECTICIDE Action MODE 3D-QSAR

硫酸镁在恶性高热治疗中的作用被引量：2: 《临床麻醉学杂志》2019年第1期85-87,共3页刘瑞莲许学兵; 深圳市科创委课题<硫酸镁治疗恶性高热的可行性实验研究>(JCYJ20150331142757390); 恶性高热(malignant hyperthermia,MH)是在特异性药物触发下肌纤维持续强直性收缩,并随之出现产热量急剧增加、组织缺氧、酸中毒及肌肉细胞坏死、弥漫性血管内凝血、心血管功能衰竭等表现的一种疾病。目前认为骨骼肌细胞Ryanodine受体1(...; 关键词：高热治疗恶性高热硫酸镁细胞内CA^2+浓度 RYANODINE 弥漫性血管内凝血 receptor CA^2+释放

Xyloketal B exerts antihypertensive effect in renovascular hypertensive rats via the NO-sGC-cGMP pathway and calcium signaling被引量：5: 《Acta Pharmacologica Sinica》2018年第5期875-884,共10页Li-yan ZHAO Jie LI Xiong-qing HUANG Guo-hao WANG Xiao-fei LV Wei-feng MENG Wen-liang CHEN Ji-yan PANG Yong-cheng LIN Hong-shuo SUN Guan-lei WANG Yao-min DU; This study was supported by grants from the National Natural Science Foundation of China （No 81370897 and 81402926）, the NSFC-CIHR China-Canada Joint Health Research Initiative Proposal （No 81361128011）, the CIHR-NSFC China-Canada Joint Health Research Initiative （CIHR, FRN #132571）, the National Key New Drug Creation Program （No 2009ZX09103- 039）, the Research Funds for Provincial Key Laboratory from the Department of Education of Guangdong Province （No50000-3211105）, the Guangdong Natural Science Foundation （No 2016A030313293）, Guangdong Provincial Department of Science and Technology （No 2016A050502023, No 2017A020215104） and the Science and Technology Program of Guangzhou （No 201509010012）.; Xyloketal B （Xyl-B） is a novel marine compound isolated from mangrove fungus Xylaria sp. （No 2508）. We previously showed that XyI-B promoted endothelial NO release and protected against atherosclerosis through the...; 关键词：hypertension two-kidney two-clip renovascular hypertensive rats aortic rings smooth muscle cells xyloketal B NO-sGC- cGMP pathway SNP methylene blue INDOMETHACIN KCl RYANODINE

The Efficacy of Microcurrent Therapy on Eccentric Contraction-Induced Muscle Damage in Rat Fast-Twitch Skeletal Muscle: 《Open Journal of Applied Sciences》2018年第3期89-102,共14页Yosuke Hiroshige Daiki Watanabe Chihiro Aibara Keita Kanzaki Satoshi Matsunaga Masanobu Wada; Microcurrent (MC) therapy, in which a very small electric current is applied to the body, has widely been used to promote tissue healing and relieve symptoms. The aim of this study was to examine the effect of MC trea...; 关键词：RYANODINE RECEPTOR Sarcoplasmic Reticulum SERCA MYOSIN ATPASE

Design, Synthesis and Insecticidal Evaluation of Anthranilic Diamides Containing Optically Pure Amino Acid Moiety被引量：2: 《Chinese Journal of Chemistry》2016年第12期1218-1224,共7页Shaa Zhou Sha Zhou Xuewen Hua Wei Wei Yongtao Xie Minggui Chen Xiangde Meng Ming Liu Lixia Xiong Na Yang Baolei Wang Zhengming Li; Two series of N-pyridylpyrazolecarboxamide derivatives were designed and synthesized by introducing D-alanine acid esters and D-serine acid esters into the skelecton of chlorantraniliprole. The obtained structures wer...; 关键词：RYANODINE amino acid insecticidal activity

Design, synthesis and insecticidal activity of biphenyl-diamide derivatives被引量：1: 《Chinese Chemical Letters》2016年第3期321-324,共4页Ye Liu Chao Lei Xiao-Yong Xu Xu-Sheng Shao Zhong Li; Diamides acting on insect ryanodine receptors are an intensive research area now. In order to search for novel candidates, a series of diamides containing biphenyl substructure were designed and synthesized.Their inse...; 关键词：Diamide Insecticide Ryanodine insecticide Biphenyl

睾酮对去势急性心肌梗死大鼠心肌细胞2型Ryanodine受体磷酸化的影响: 《山东医药》2016年第2期26-27,共2页李永健陈康寅王林; 目的探讨睾酮对去势急性心肌梗死(AMI)大鼠左心室功能、心肌细胞2型Ryanodine受体(RYR2)、磷酸化RYR2(RYR2P)及其亚单位钙稳蛋白2(FKBP12.6)表达的影响。方法采用去势术联合冠状动脉结扎术建立雄性SD大鼠去势AMI模型,随机分为对照组、...; 关键词：急性心肌梗死睾酮 2型Ryanodine受体大鼠

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