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作品数:101被引量:254H指数:7
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相关领域:医药卫生更多>>
相关作者:邱光苏国辉刘汇文李湄珍邓兆华更多>>
相关机构:福建医科大学加州大学香港大学中南大学更多>>
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相关基金:国家自然科学基金中国博士后科学基金国家重点基础研究发展计划福建省自然科学基金更多>>
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Induction of translation-suppressive G3BP1+stress granules and interferonsignaling cGAS condensates by transfected plasmid DNA
《hLife》2025年第1期21-37,共17页Vladimir Majerciak Zhi-Ming Zheng 
supported by the Intramural Research Program of the National Institutes of Health,the National Cancer Institute,and the Center for Cancer Research(ZIASC010357 to Z.M.Z.).
Plasmid DNA transfection is one of the fundamental tools of biomedical research.Here,we found that plasmid DNA transfection mediated by liposomes activates multiple innate immune responses in several widely used cell ...
关键词:plasmid DNA TRANSFECTION stress granules cyclic GMP-AMP synthase(cGAS) Kaposi’s sarcoma-associated herpesvirus(KSHV) protein kinase R(PKR) 
Therapeutic Insights into Low-intensity Vibration for Generating Induced Tumor-Suppressive Cells and Modulating the Bone Microenvironment
《Engineering》2024年第12期201-215,共15页Xue Xiong Qingji Huo Changpeng Cui Uma KAryal BonHeon Ku Chin-Suk Hong HeeChang Lim Jing Liu Andy Chen William R.Thompson Bai-Yan Li Xue-Lian Li Hiroki Yokota 
funded by the Indiana Clinical and Translational Science Institute and Showalter Trust (to Uma K. Aryal);the Human Resources Program in Energy Technology of the Korea Institute of Energy Technology Evaluation and Planning (20214000000140 (to HeeChang Lim));the National Institutes of Health R35GM147412 (to Jing Liu) and R01AR074473 (to William R. Thompson);the National Natural Science Foundation of China, 81971326 (to Bai-Yan Li);the 100 Voices of Hope (to Hiroki Yokota)。
Bone frequently serves as a metastatic site for breast and prostate cancers. Given the potential of low-intensity vibration(LIV) to increase bone health and reduce cancer risk, this study investigated the impact of LI...
关键词:Low-intensity vibrations Induced tumor-suppressing cells Lymphocytes Breast cancer Bone metastasis 
SEC61 translocon gamma subunit is correlated with glycolytic activity,epithelial mesenchymal transition and the immune suppressive phenotype of lung adenocarcinoma
《Acta Biochimica et Biophysica Sinica》2024年第12期1748-1760,共13页Changshuai Zhou Huanhuan Cui Yuechao Yang Lei Chen Mingtao Feng Yang Gao Deheng Li Liangdong Li Xin Chen Xiaoqiu Li Yiqun Cao 
supported by the grants from the National Natural Science Foundation of China(Nos.82173177 and 82103429).
Lung adenocarcinoma(LUAD)remains a predominant cause of cancer-related mortality globally,underscoring the urgency for targeted therapeutic strategies.The specific role and impact of the SEC61 translocon gamma subunit...
关键词:SEC61G lung adenocarcinoma tumor immune microenvironment GLYCOLYSIS epithelial mesenchymal transition 
Beyond the Gut:The intratumoral microbiome’s influence on tumorigenesis and treatment response
《Cancer Communications》2024年第10期1130-1167,共38页Hao Zhang Li Fu Xinwen Leiliang Chunrun Qu Wantao Wu Rong Wen Ning Huang Qiuguang He Quan Cheng Guodong Liu Yuan Cheng 
National Natural Science Foundation of China,Grant/Award Numbers:82372943,82303610;Hunan Provincial Natural Science Foundation of China,Grant/Award Number:2022JJ20095;Hunan Youth Science and Technology Talent Project,Grant/Award Number:2023RC3074;China Postdoctoral Science Foundation,Grant/Award Number:2023MD734131;Chongqing Postdoctoral Science Foundation,Grant/Award Number:CSTB2023NSCQBHX0002;Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University;Chongqing Postdoctoral Research Special Funding Project,Grant/Award Number:2023CQBSHTB3095。
The intratumoral microbiome(TM)refers to the microorganisms in the tumor tissues,including bacteria,fungi,viruses,and so on,and is distinct from the gut microbiome and circulating microbiota.TM is strongly associated ...
关键词:analysis methods IMMUNOTHERAPY intratumoral microbiome treatment application tumorpromotive and tumor-suppressive mechanisms 
Revealing the crucial roles of suppressive immune microenvironment in cardiac myxoma progression
《Signal Transduction and Targeted Therapy》2024年第9期4014-4029,共16页Zedong Jiang Qianlong Kang Hong Qian Zhijie Xu Huan Tong Jiaqing Yang Li Li Renwei Li Guangqi Li Fei Chen Nan Lin Yunuo Zhao Huashan Shi Juan Huang Xuelei Ma 
supported by the Natural Science Foundation of Sichuan Province(2022NSFSC0774);the Sichuan Science and Technology Regional Collaboration Project(2023YFQ0012).
Cardiac myxoma is a commonly encountered tumor within the heart that has the potential to be life-threatening.However,the cellular composition of this condition is still not well understood.To fill this gap,we analyze...
关键词:MYXOMA CARDIAC IMPAIRED 
Suppressive effects of exercise-conditioned serum on cancer cells:A narrative review of the influence of exercise mode,volume,and intensity被引量:1
《Journal of Sport and Health Science》2024年第4期484-498,F0003,共16页Francesco Bettariga Dennis R.Taaffe Daniel A.Galvao Chris Bishop Jin-Soo Kim Robert U.Newton 
Cancer is a major cause of morbidity and mortality worldwide,and the incidence is increasing,highlighting the need for effective strategies to treat this disease.Exercise has emerged as fundamental therapeutic medicin...
关键词:Cancer cells High intensity interval training Moderate intensity continuous training Resistance training MYOKINES 
Converting“cold”to“hot”:epigenetics strategies to improve immune therapy effect by regulating tumor-associated immune suppressive cells被引量:4
《Cancer Communications》2024年第6期601-636,共36页Yijia Tang Guangzu Cui Haicong Liu Ying Han Changjing Cai Ziyang Feng Hong Shen Shan Zeng 
National Natural Science Foundation of China,Grant/Award Numbers:82373275,81974384,82173342,82203015;China Postdoctoral Science Foundation,Grant/Award Number:2023JJ40942;Nature Science Foundation of Hunan Province,Grant/Award Numbers:2021JJ3109,2021JJ31048,2023JJ40942;Nature Science Foundation of Changsha,Grant/Award Number:73201;CSCO Cancer Research Foundation,Grant/Award Numbers:Y-HR2019-0182,Y-2019Genecast-043;the Key Research and Development Program of Hainan Province,Grant/Award Numbers:ZDYF2020228,ZDYF2020125。
Significant developments in cancer treatment have been made since the advent of immune therapies.However,there are still some patientswithmalignant tumors who do not benefit from immunotherapy.Tumors without immunogen...
关键词:DNA methylation epigenetics strategy histone modification immune suppressive cell noncoding RNA 
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
《Cellular & Molecular Immunology》2024年第5期495-509,共15页Ronja Wieboldt Michael Sandholzer Emanuele Carlini Chia-wei Lin Anastasiya Börsch Andreas Zingg Didier Lardinois Petra Herzig Leyla Don Alfred Zippelius Heinz Läubli Natalia Rodrigues Mantuano 
supported by funding from the Swiss National Science Foundation(SNSF Grant No.310030-215237/1);the Schoenmakers-Müller Foundation,a research grant from Ono Pharmaceuticals,and the Cancer League of Basel(KlbB).Open access funding provided by University of Basel.
The overexpression of sialic acids on glycans,called hypersialylation,is a common alteration found in cancer cells.Sialylated glycans can enhance immune evasion by interacting with sialic acid-binding immunoglobulin-l...
关键词:sialoglycans Sialic acid-binding immunoglobulin-like lectin tumor microenvironment myeloid derived suppressor cells 
MicroRNAs modulation in lung cancer: exploring dual mechanisms and clinical prospects
《BIOCELL》2024年第3期403-413,共11页SHAHID HUSSAIN HABIB BOKHARI XINGXING FAN SHAUKAT IQBAL MALIK SUNDAS IJAZ MUHAMMAD ADNAN SHEREEN AIMAN FATIMA 
The global incidence of lung cancer is marked by a considerably elevated mortality rate.MicroRNAs(miRNAs)exert pivotal influence in the intricate orchestration of gene regulation,and their dysregulation can precipitate...
关键词:MIRNAS ONCOGENES Tumor suppressive genes Lung cancer therapy 
Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive FAT1 and inhibits stemness maintenance in thyroid carcinoma
《Frontiers of Medicine》2023年第6期1186-1203,共18页Jie Shao Wenjuan Wang Baorui Tao Zihao Cai Haixia Li Jinhong Chen 
supported by Shanghai Shenkang Hospital Development Center(No.SHDC12019X38).
Through bioinformatics predictions,we identified that GTF2I and FAT1 were downregulated in thyroid carcinoma(TC).Further,Pearson’s correlation coefficient revealed a positive correlation between GTF2I expression and ...
关键词:thyroid carcinoma mesenchymal stem cell extracellular vesicle GTF2I FAT1 CDK4 
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