IMMUNOMODULATION

作品数:259被引量:1340H指数:16
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相关领域:医药卫生更多>>
相关作者:龚明玉商亚珍李素婷周晓霞王宝元更多>>
相关机构:武汉大学承德医学院南京医科大学南京大学更多>>
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相关基金:国家自然科学基金中国博士后科学基金国家重点基础研究发展计划北京市自然科学基金更多>>
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  • 期刊=World Journal of Stem Cellsx
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Fetal mice dermal mesenchymal stem cells promote wound healing by inducing M2 type macrophage polarization
《World Journal of Stem Cells》2025年第2期96-104,共9页Zhen-Yu Xia Yi Wang Nian Shi Mei-Qi Lu Yun-Xiang Deng Yong-Jun Qi Xing-Lei Wang Jie Zhao Du-Yin Jiang 
National Natural Science Foundation of China,No.81873934;and Jinan Science and Technology Planning Project,No.202225065.
BACKGROUND Mesenchymal stem cells,found in various tissues,possess significant healing and immunomodulatory properties,influencing macrophage polarization,which is essential for wound repair.However,chronic wounds pre...
关键词:Fetal dermal mesenchymal stem cells Macrophage polarization Wound healing IMMUNOMODULATION M2 phenotype 
Mesenchymal stem cells and their derived exosomes for the treatment of COVID-19
《World Journal of Stem Cells》2024年第4期353-374,共22页Xiang-Yi Hou La-Mu Danzeng Yi-Lin Wu Qian-Hui Ma Zheng Yu Mei-Ying Li Li-Sha Li 
Supported by Science and Technology Department Project of Jilin Province,China,No.20230101163JC;the Outstanding Youth Fund Project of Jilin Provincial Department of Education,China,No.JJKH20241324KJ.
Coronavirus disease 2019(COVID-19)is an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).SARS-CoV-2 infection typically presents with fever and respiratory symptoms,whi...
关键词:COVID-19 Cytokine storm IMMUNOMODULATION Mesenchymal stem cell Mesenchymal stem cell-derived exosomes 
Interferon-gamma and tumor necrosis factor-alpha synergistically enhance the immunosuppressive capacity of human umbilical-cordderived mesenchymal stem cells by increasing PD-L1 expression被引量:1
《World Journal of Stem Cells》2023年第8期787-806,共20页Zhuo Chen Meng-Wei Yao Zhi-Lin Shen Shi-Dan Li Wei Xing Wei Guo Zhan Li Xiao-Feng Wu Luo-Quan Ao Wen-Yong Lu Qi-Zhou Lian Xiang Xu Xiang Ao 
Supported by the National Natural Science Foundation of China,No.81871568,No.32100643;COVID-19 Infection and Prevention Emergency Special Project of Chongqing Education Commission,No.KYYJ202009.
BACKGROUND The immunosuppressive capacity of mesenchymal stem cells(MSCs)is dependent on the“license”of several proinflammatory factors to express immunosuppressive factors such as programmed cell death 1 ligand 1(P...
关键词:Human umbilical-cord-derived mesenchymal stem cells Programmed cell death 1 ligand 1 IMMUNOMODULATION INTERFERON-GAMMA Tumor necrosis factor-alpha Ulcerative colitis 
Immunomodulation:The next target of mesenchymal stem cell-derived exosomes in the context of ischemic stroke
《World Journal of Stem Cells》2023年第3期52-70,共19页Xiao-Qian Shan Yong-Yin Luo Jun Chang Jing-Jing Song Nan Hao Lan Zhao 
Supported by National Natural Science Foundation of China,No.82074533.
Ischemic stroke(IS)is the most prevalent form of brain disease,characterized by high morbidity,disability,and mortality.However,there is still a lack of ideal prevention and treatment measures in clinical practice.Not...
关键词:Mesenchymal stem cells EXOSOMES Ischemic stroke IMMUNOMODULATION INFLAMMATION Exosome therapy 
Anti-fibrotic effect of adipose-derived stem cells on fibrotic scars
《World Journal of Stem Cells》2022年第2期200-213,共14页Sophie Vanderstichele Jan Jeroen Vranckx 
BACKGROUND Sustained injury,through radiotherapy,burns or surgical trauma,can result in fibrosis,displaying an excessive deposition of extracellular matrix(ECM),persisting inflammatory reaction,and reduced vasculariza...
关键词:FIBROSIS Fat grafting Adipose-derived stem cells ANGIOGENESIS Anti-fibrotic effect IMMUNOMODULATION 
Application of adipose-derived stem cells in treating fibrosis被引量:1
《World Journal of Stem Cells》2021年第11期1747-1761,共15页Zhu-Jun Li Li-Quan Wang Yun-Zhu Li Chen-Yu Wang Jiu-Zuo Huang Nan-Ze Yu Xiao Long 
Supported by the National Natural Science Foundation of China,No.81670444;and the CAMS Innovation Fund for Medical Sciences(CIFMS),No.2020-I2MC&T-A-004.
Fibrosis is the hyperactivation of fibroblasts that results in excessive accumulation of extracellular matrix,which is involved in numerous pathological changes and diseases.Adipose-derived stem cells(ASCs)are promisi...
关键词:Adipose-derived stem cells FIBROSIS IMMUNOMODULATION MODIFICATION Therapeutic effect Clinical trials 
Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages被引量:2
《World Journal of Stem Cells》2021年第9期1160-1176,共17页Alexia Nedel Sant'Ana Anelise Bergmann Araújo Fabiany da Costa Gonçalves Ana Helena Paz 
Fundo de IncentivoàPesquisa e Eventos(Fipe)-Hospital de Clínicas de Porto Alegre,No.GPPG 2017-0004.
Mesenchymal stromal cells (MSCs) are multipotent and self-renewing stem cellsthat have great potential as cell therapy for autoimmune and inflammatorydisorders, as well as for other clinical conditions, due to their i...
关键词:Mesenchymal stromal cells MACROPHAGE MONOCYTE IMMUNOMODULATION Cell therapy IMMUNOREGULATION 
Review of the potential of mesenchymal stem cells for the treatment of infectious diseases被引量:4
《World Journal of Stem Cells》2021年第6期568-593,共26页Amit Sharma Anuja Chakraborty Bithiah Grace Jaganathan 
The therapeutic value of mesenchymal stem cells (MSCs) for the treatment of infectious diseases and the repair of disease-induced tissue damage has been explored extensively. MSCs inhibit inflammation, reduce pathogen...
关键词:Infectious diseases Mesenchymal stem cells Antimicrobial effect IMMUNOMODULATION Tissue repair COVID-19 
Targeting mesenchymal stem cell therapy for severe pneumonia patients被引量:4
《World Journal of Stem Cells》2021年第2期139-154,共16页Guy Lam Yuan Zhou Jia-Xian Wang Yat-Ping Tsui 
Supported by the Project Contract for Technical Innovation Project for Small and Medium-sized Science and Technology Enterprises in Jiangning District,No.2020JSCX0563.
Pneumonia is the inflammation of the lungs and it is the world’s leading cause of death for children under 5 years of age.The latest coronavirus disease 2019(COVID-19)virus is a prominent culprit to severe pneumonia....
关键词:PNEUMONIA Human mesenchymal stem cells IMMUNOMODULATION Alveolar protection Pandemic challenge Clinical trials 
Prospects for the therapeutic development of umbilical cord bloodderived mesenchymal stem cells被引量:6
《World Journal of Stem Cells》2020年第12期1511-1528,共18页Soyoun Um Jueun Ha Soo Jin Choi Wonil Oh Hye Jin Jin 
Umbilical cord blood(UCB)is a primitive and abundant source of mesenchymal stem cells(MSCs).UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and disorders.Despite the high lat...
关键词:Umbilical cord blood Mesenchymal stem cell Stem cell therapy IMMUNOMODULATION Regenerative medicine Therapeutic cell manufacturing processing 
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