SKELETON

作品数：439被引量：687H指数：12
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Ageing-related bone and immunity changes:insights into the complex interplay between the skeleton and the immune system
《Bone Research》2024年第3期502-516,共15页Bobin Mi Yuan Xiong Samuel Knoedler Michael Alfertshofer Adriana C.Panayi Haixing Wang Sien Lin Gang Li Guohui Liu 
supported by the National Key R&D Program of China (2021YFA1101500);Wuhan Science and Technology Bureau (2022020801020464);partially supported by University Grants Committee,Research Grants Council of the Hong Kong Special Administrative Region,China (14113723,N_CUHK472/22,T13-402/17-N and AoE/M-402/20);Direct Grant of CUHK (2022.042)。
Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues,including the skeletal and immune systems.Recent studies have elucidated the intricate ...
关键词：SKELETON INSIGHT IRREVERSIBLE 
Metabolic reprogramming in skeletal cell differentiation
《Bone Research》2024年第3期539-554,共16页Joshua C.Bertels Guangxu He Fanxin Long 
partly supported by NIH grant R01DK125498 (FL)。
The human skeleton is a multifunctional organ made up of multiple cell types working in concert to maintain bone and mineral homeostasis and to perform critical mechanical and endocrine functions.From the beginning st...
关键词：FUNCTIONS SKELETON PROGRAMMING 
Neuro-bone tissue engineering:emerging mechanisms,potential strategies,and current challenges被引量：2
《Bone Research》2023年第4期695-720,共26页Wenzhe Sun Bing Ye Siyue Chen Lian Zeng Hongwei Lu Yizhou Wan Qing Gao Kaifang Chen Yanzhen Qu Bin Wu Xiao Lv Xiaodong Guo 
supported by the National Natural Science Foundation of China(Grant Nos.82072446,81873999,82272460,82202715,82102546,82102627);the Natural Science Foundation of Hubei Province(2021CFB277,2021CFB596)。
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells.Peripheral nerve endings release neurogenic factors and sense skeletal signals,which mediate bone metabolism and ske...
关键词：METABOLISM MECHANISMS SKELETON 
Glucose uptake and distribution across the human skeleton using state-of-the-art total-body PET/CT
《Bone Research》2023年第3期586-594,共9页Weizhao Lu Yanhua Duan Kun Li Jianfeng Qiu Zhaoping Cheng 
supported by the Science and Technology Funding from Jinan (grant number:2020GXRC018);the Academic Promotion Program of Shandong First Medical University (grant number:2019QL009);the Taishan Scholars Program of Shandong Province (grant number:TS201712065)。
A growing number of studies have demonstrated that the skeleton is an endocrine organ that is involved in glucose metabolism and plays a significant role in human glucose homeostasis.However,there is still a limited u...
关键词：METABOLISM SKELETON ORGANS 
Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment被引量：2
《Bone Research》2022年第1期107-121,共15页Anke Baranowsky Denise Jahn Shan Jiang Timur Yorgan Peter Ludewig Jessika Appelt Kai K.Albrecht Ellen Otto Paul Knapstein Antonia Donat Jack Winneberger Lana Rosenthal Paul Köhli Cordula Erdmann Melanie Fuchs Karl-Heinz Frosch Serafeim Tsitsilonis Michael Amling Thorsten Schinke Johannes Keller 
funded by grants from the Else-Kr?ner-Fresenius-Stiftung (EKFS 2017_A22);the German Research Foundation (DFG KE 2179/4-1);the Berlin Institute of Health to JK;from the Hertie-Stiftung (Hertie Academy of Clinical Neuroscience);the German Research Foundation (DFG;grant numbers: DFG FOR 2879 [project LU 1924/1-]) to PL.
Intermittent injections of parathyroid hormone(iPTH) are applied clinically to stimulate bone formation by osteoblasts, although continuous elevation of parathyroid hormone(PTH) primarily results in increased bone res...
关键词：TREATMENT representing SKELETON 
Roles of mechanosensitive channel Piezo 1/2 proteins in skeleton and other tissues被引量：28
《Bone Research》2021年第4期456-472,共17页Lei Qin Tailin He Sheng Chen Dazhi Yang Weihong Yi Huiling Cao Guozhi Xiao 
This work was supported by the National Key Research and Development Program of China Grant(2019YFA0906004);the National Natural Science Foundation of China Grants(81991513,82022047,81630066,81870532,81972100);the Guangdong Provincial Science and Technology Innovation Council Grant(2017B030301018);the Science and Technology Innovation Commission of Shenzhen Municipal Government Grants(JCYJ20180302174117738,JCYJ20180302174246105,KQJSCX20180319114434843,JSGG20180503182321166);the China Postdoctoral Science Foundation(2019M651641).
Mechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from both the external and internal environments.The mechanotransduction process requires a range of...
关键词：MEC SENSATION ORGANS 
Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis被引量：7
《Bone Research》2021年第3期264-283,共20页Ming Chen Yi Li Xiang Huang Ya Gu Shang Li Pengbin Yin Licheng Zhang Peifu Tang 
funded by the National Natural Science Foundation of China(81972102,81772369,81972115,82002330 and 81702176).
Angiogenesis and osteogenesis are coupled.However,the cellular and molecular regulation of these processes remains to be further investigated.Both tissues have recently been recognized as endocrine organs,which has st...
关键词：HOMEOSTASIS ORGANS diseases 
PGE2/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib被引量：6
《Bone Research》2021年第3期396-409,共14页Peng Xue Shenyu Wang Xiao Lyu Mei Wan Xialin Li Lei Ma Neil CFord Yukun Li Yun Guan Wenyuan Ding Xu Cao 
supported by National Institute on Aging of the National Institutes of Health under Award Number R01 AG068997 and P01 AG066603(to X.C.).
Skeletal interoception regulates bone homeostasis through the prostaglandin E2(PGE2)concentration in bone.Vertebral endplates undergo ossification and become highly porous during intervertebral disc degeneration and a...
关键词：pain DOSAGE IMPAIRED 
Ultra-processed food targets bone quality via endochondral ossification被引量：1
《Bone Research》2021年第2期200-212,共13页Janna Zaretsky Shelley Griess-Fishheimer Adi Carmi Tamara Travinsky Shmul Lior Ofer Tali Sinai Svetlana Penn Ron Shahar Efrat Monsonego-Ornan 
supported by the Israel Science Foundation(Grant No.1050/13).
Ultra-processed foods have known negative implications for health;however,their effect on skeletal development has never been explored.Here,we show that young rats fed ultra-processed food rich in fat and sugar suffer...
关键词：consuming SUGAR SKELETON 
Chronic kidney disease and the skeleton被引量：1
《Bone Research》2014年第4期205-217,共13页Paul D Miller 
Fractures across the stages of chronic kidney disease （CKD） could be due to osteoporosis, some form of renal osteodystrophy defined by specific quantitative histomorphometry or chronic kidney disease-mineral and bon...
关键词：CKD GFR PTH MBD 
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