PHOSPHOINOSITIDE

作品数：74被引量：298H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：关宇翔张剑锋更多>>
相关机构：中山医学大学中国医科大学西安交通大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划泰国研究基金更多>>
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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway
《Neural Regeneration Research》2025年第11期3245-3258,共14页Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu 
supported by the National Nature Science Foundation of China,No.81471308(to JL);the Innovative Leading Talents of Liaoning Province,No.XLYC1902031(to JL);Science and Technology Projects in Liaoning Province,No.2022-BS-238(to CH);Young Top Talents of Liaoning Province,No.XLYC1907009(to LW);Dalian Science and Technology Innovation Fund,No.2018J11CY025(to JL)。
Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem ce...
关键词：behavior EXOSOME extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT) 
Soy lecithin in combination with soy isoflavones improves learning and memory impairments in rats by modulating cerebral vasodilation
《Food Science and Human Wellness》2025年第4期1330-1342,共13页Dajun Li Xianyun Wang Chengyan Qi Huini Ding Jing Shen Hongmei Huang Yuandi Xi 
supported by the National Natural Science Foundation of China(82273620,81302427)。
Identifying a potential dietary non-pharmacological treatment to prevent cerebrovascular damage in Alzheimer's disease is crucial for alleviating cognitive decline in older adults and enhancing quality of life.This st...
关键词：Cognitive impairment Cerebral vasodilation LECITHIN ISOFLAVONES Endothelial nitric oxide synthase(eNOS) Phosphoinositide-dependent kinase-1(PDK-1) 
To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway
《World Journal of Gastrointestinal Oncology》2025年第3期270-290,共21页Zhuo-Cong Bao Zhao-Dong Liu Ye Zhang Hui-Jun Dai Hui Jia Fu Ren Ning Li Lu Zhao Yi-Wei Wang Shang-Yu Lv Yan Zhang 
the Central Government Guidance Local Science and Technology Development Fund,No.2023JH6/100100021;Liaoning Province Education Department Foundation of China,No.JYTMS20231393;Scientific Research Project of Liaoning Province Education Department,No.SYYX2019015;Science and Technology Fund of Shenyang Medical College,No.20171004,Shenyang Medical College Master’s Science and Technology Innovation Fund,No.Y20220509;Liaoning Provincial Department of Education Scientific Research Project,No.LJ212410164032.
BACKGROUND Liver cancer has a high incidence and mortality worldwide,especially in China.Herein,we investigated the therapeutic effect and mechanism of tetrahydrocurcumin against hepatocellular carcinoma(HCC),with a f...
关键词：Hepatocellular carcinoma TETRAHYDROCURCUMIN Network pharmacology Molecular docking PI3K/AKT signaling pathway 
Dapagliflozin exerts anti-apoptotic effects by mitigating macrophage polarization via modulation of the phosphoinositide 3-kinase/protein kinase B signaling pathway
《World Journal of Diabetes》2025年第2期163-174,共12页Sheng-Xi Xiong Lin-Juan Huang Han-Shuang Liu Xiao-Xiao Zhang Min Li Yu-Bing Cui Chen Shao Xiao-Lei Hu 
Natural Science Foundation of Anhui Province,No.2208085MH216;Major Natural Science and Technology Project of Bengbu Medical College,No.2020byfy004;Scientific Research Program of Anhui Provincial Health Commission,No.AHWJ2023BAc10028.
BACKGROUND Macrophages are central to the orchestration of immune responses,inflammatory processes,and the pathogenesis of diabetic complications.The dynamic polarization of macrophages into M1 and M2 phenotypes criti...
关键词：DAPAGLIFLOZIN Macrophage polarization INFLAMMATION Macrophage apoptosis Phosphoinositide 3-kinase/protein kinase B signaling pathway 
Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models
《World Journal of Stem Cells》2025年第1期22-39,共18页Jing Yang Jun Yuan Yan-Qing Wen Li Wu Jiu-Jiang Liao Hong-Bo Qi 
support from the“111 program”of Ministry of Education of China and State Administration of Foreign Experts Affairs of China.
BACKGROUND Uterine injury can cause uterine scarring,leading to a series of complications that threaten women’s health.Uterine healing is a complex process,and there are currently no effective treatments.Although our...
关键词：Uterine injury Bone marrow mesenchymal stem cells Uterine smooth muscle cells Phosphoinositide 3-kinase/protein kinase B pathway Cell-cell interactions Cell proliferation Immune regulation Wound regeneration 
BIRC3 induces the phosphoinositide 3-kinase-Akt pathway activation to promote trastuzumab resistance in human epidermal growth factor receptor 2-positive gastric cancer
《World Journal of Gastrointestinal Oncology》2024年第11期4436-4455,共20页Shu-Liang Li Pei-Yao Wang Yang-Pu Jia Zhao-Xiong Zhang Hao-Yu He Peng-Yu Chen Xin Liu Bang Liu Li Lu Wei-Hua Fu 
the Tianjin Municipal Education Commission Scientific Research Project,No.2018KJ055.
BACKGROUND Trastuzumab-targeted therapy is currently the standard of care for advanced human epidermal growth factor receptor 2(HER2)-positive gastric cancer.However,the emergence of resistance to trastuzumab poses si...
关键词：Gastric cancer Human epidermal growth factor receptor 2 TRASTUZUMAB DRUG-RESISTANCE BIRC3 
Banxia xiexin decoction prevents the development of gastric cancer
《World Journal of Clinical Oncology》2024年第10期1293-1308,共16页Guo-Xiu Zu Ke-Yun Sun Xi-Jian Liu Ji-Qin Tang Hai-Liang Huang Tao Han 
Supported by the Key Program of Shandong Province,China,No.2016CYJS08A01-6.
BACKGROUND In China banxia xiexin decoction(BXD)has been used in treating gastric cancer(GC)for thousands of years and BXD has a good role in reversing GC histopathology,but its chemical composition and action mechani...
关键词：Banxia xiexin decoction Gastric cancer Ultra-performance liquid chromatography tandem quadrupole elec-trostatic field orbitrap mass spectrometry Network pharmacology Whole transcriptomic sequencing Phosphoinositide 3-kinase/protein kinase B signaling pathway 
Scorpiones,Scolopendra and Gekko Inhibit Lung Cancer Growth and Metastasis by Ameliorating Hypoxic Tumor Microenvironment via PI3K/AKT/mTOR/HIF-1αSignaling Pathway
《Chinese Journal of Integrative Medicine》2024年第9期799-808,共10页MAO Qi-yuan WANG Xue-qian LIN Fei YU Ming-wei FAN Hui-ting ZHENG Qi LIU Lan-chun ZHANG Chu-chu LI Dao-rui LIN Hong-sheng 
Supported by the Special Scientific Research Project of the Chinese Medicine Industry of the State Administration of Traditional Chinese Medicine of China(No.201307006);National Natural Science Foundation of China(No.82104656,82004179,82074405);Fundamental Research Funds for the Central Public Welfare Research Institutes(No.ZZ14-YQ-013,ZZ15-YQ-024)。
Objective:To investigate whether Buthus martensii karsch(Scorpiones),Scolopendra subspinipes mutilans L.Koch(Scolopendra)and Gekko gecko Linnaeus(Gekko)could ameliorate the hypoxic tumor microenvironment and inhibit l...
关键词：SCORPIONES SCOLOPENDRA Gekko dredging collaterals and activating blood Chinese medicine of worms lung cancer hypoxic tumor microenvironment phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling pathway 
Integrative analyses identified gap junction beta‐2 as a prognostic biomarker and therapeutic target for breast cancer
《Cancer Innovation》2024年第4期43-56,共14页Di Zhang Lixi Li Fei Ma 
Background:Increasing evidence has shown that connexins are involved in the regulation of tumor development,immune escape,and drug resistance.This study investigated the gene expression patterns,prognostic values,and ...
关键词：breast cancer CONNEXIN gap junction beta‐2 phosphoinositide 3‐kinase‐Akt‐mTOR pathway prognosis 
RBM5 suppresses proliferation,metastasis and glycolysis of colorectal cancer cells via stabilizing phosphatase and tensin homolog mRNA
《World Journal of Gastrointestinal Oncology》2024年第7期3241-3255,共15页Chu-Xiang Wang Feng Liu Yi Wang 
BACKGROUND RNA binding motif 5(RBM5)has emerged as crucial regulators in many cancers.AIM To explore more functional and mechanistic exploration of RBM5 since the lack of research on RBM5 in colorectal cancer(CRC)dict...
关键词：Colorectal cancer RNA binding motif 5 Phosphatase and tensin homolo Phosphoinositide 3-kinase/anti-protein kinase GLYCOLYSIS 
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