MONOPHOSPHATE

作品数：92被引量：261H指数：8
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相关机构：南京工业大学南京大学福建中医药大学中国人民解放军第一军医大学更多>>
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相关基金：国家自然科学基金福建省自然科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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  • 期刊=World Journal of Gastroenterologyx
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Fanlian Huazhuo Formula:A promising herbal preparation for metabolic liver disease被引量：1
《World Journal of Gastroenterology》2024年第46期4964-4968,共5页Bhupesh Singla 
Supported by the National Institutes of Health Grants,No.K99HL146954 and No.R00HL146954;the College of Pharmacy Seed Research Grant Program of the University of Tennessee Health Science Center.
The prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)has increased significantly in recent decades and is projected to increase further due to the rising obesity rates.MASLD patients are at...
关键词：Metabolic dysfunction-associated steatotic liver disease Fanlian Huazhuo Formula De novo lipogenesis Cell death Adenosine-5’-monophosphate-activated protein kinase alpha Acetyl-CoA carboxylase 
Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension被引量：2
《World Journal of Gastroenterology》2018年第38期4356-4368,共13页Denise Schaffner Adhara Lazaro Peter Deibert Peter Hasselblatt Patrick Stoll Lisa Fauth Manfred W Baumstark Irmgard Merfort Annette Schmitt-Graeff Wolfgang Kreisel 
AIM To investigate the potential effect of inhibitors of phosphodiesterase-5(PDE-5) for therapy of portal hypertension in liver cirrhosis.METHODS In the rat model of thioacetamide-induced liver fibrosis/cirrhosis the ...
关键词：Portal hypertension THIOACETAMIDE Nitric oxide Liver cirrhosis Cyclic GUANOSINE MONOPHOSPHATE Phosphodiesterase-5 SILDENAFIL Hepatic stellate cells Metabolic zonation 
Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models被引量：6
《World Journal of Gastroenterology》2018年第17期1888-1900,共13页Illona-Marie Boulete Anusha Thadi Catherine Beaufrand Viren Patwa Apoorva Joshi John A Foss E Priya Eddy Helene Eutamene Vaseem A Palejwala Vassilia Theodorou Kunwar Shailubhai 
Supported by Synergy Pharmaceuticals Inc.,which provided the funding and the plecanatide,dolcanatide and placebo used for these studies
AIM To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability, integrity of tight junctions and on suppression of visceral hypersensitivity. METHODS Transport of fluorescein...
关键词：Plecanatide Guanylyl cyclase-C AGONISTS Dolcanatide UROGUANYLIN PRECLINICAL cyclic GUANOSINE MONOPHOSPHATE Constipation Inflammatory bowel diseases 
Metformin attenuates motility,contraction,and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase被引量：11
《World Journal of Gastroenterology》2018年第7期819-832,共14页Zhen Li Qian Ding Li-Ping Ling Ying Wu Dong-Xiao Meng Xiao Li Chun-Qing Zhang 
Supported by National Natural Science Foundation of China,No.81370590
AIM To investigate the effect of metformin on activated hepatic stellate cells(HSCs) and the possible signaling pathways involved. METHODS A fibrotic mouse model was generated by intraperitoneal injection of carbon te...
关键词：hepatic stellate cell INTRAHEPATIC vascular resistance angiogenesis CONTRACTION liver fibrosis ADENOSINE monophosphate-activated protein kinase 
Guanylyl cyclase C signaling axis and colon cancer prevention被引量：2
《World Journal of Gastroenterology》2016年第36期8070-8077,共8页Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman 
Supported by NIH,No.R01CA170533,No.R01CA206026 and No.P30CA56036;Targeted Diagnostic and Therapeutics,Inc.;a Ruth L.Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows from the NIH,No.CA180500(To Blomain ES);a Ruth L.Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows from the NIH,No.F30 DK103492(To Merlino DJ);a Predoctoral Fellowship in Pharmacology/Toxicology from the PhR MA Foundation
Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, a...
关键词：Colorectal cancer GUANYLIN UROGUANYLIN Chemoprevention Heat-stable ENTEROTOXINS Cyclic GUANOSINE MONOPHOSPHATE Guanylyl CYCLASE C 
AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability被引量：4
《World Journal of Gastroenterology》2010年第30期3731-3742,共12页Yoon Mee Yang Chang Yeob Han Yoon Jun Kim Sang Geon Kim 
Supported by The National Research Foundation of Korea Grant,Funded by the Korea Government(MEST),No.2010-0001706,South Korea
The adenosine monophosphate-activated protein kinase (AMPK) and p70 ribosomal S6 kinase-1 pathway may serve as a key signaling flow that regulates energy metabolism; thus, this pathway becomes an attractive target for...
关键词：Adenosine monophosphate-activated protein KINASE Cell survival Energy METABOLISM Fatty liver Insulin resistance GLYCOGEN synthase KINASE 3β P70 RIBOSOMAL S6 kinase-1 
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