AGONISTS

作品数：136被引量：373H指数：10
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The dual function of cGAS-STING signaling axis in liver diseases
《Acta Pharmacologica Sinica》2024年第6期1115-1129,共15页Xiao-jao-yang Li jiao-rong Qu Yin-hao Zhang Run-ping Liu 
supported by the Beijing Nova Program of Science&Technology(Grant No.Z211100002121167 to RPL);the Fundamental Research Funds for the Central Universities to XJYL;the Fundamental Research Funds for the Central Universities(Grant No.2023-JYB-XJSJJ009 to JRQ);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.ZYYCXTD-C-202006 to XJYL);Beijing Municipal Science&Technology Commission(Grant No.7212174 to XL);National Natural Science Foundation of China(Grant No.82004045 and 82274186 to XJYL);National Key Research and Development Program on Modernization of Traditional Chinese Medicine(No.6132022YFC3502100 to XJYL);the National High-Level Talents Special Support Program to XJYL.
Numerous liver diseases,such as nonalcoholic fatty liver disease,hepatitis,hepatocellular carcinoma,and hepatic ischemia-reperfusion injury,have been increasingly prevalent,posing significant threats to global health....
关键词：STING chronic liver diseases immune response dual regulation STING agonists STING inhibitors 
Metabolic disorders in prediabetes:From mechanisms to therapeutic management被引量：1
《World Journal of Diabetes》2024年第3期361-377,共17页Wen-Xin Ping Shan Hu Jing-Qian Su Song-Ying Ouyang 
Supported by National Natural Science Foundation of China,No.31770948,No.31570875,and No.81803547;Natural Science Foundation of Fujian Province,No.2021J01204;and Fujian Provincial Regional Development Project,No.2021N3005.
Diabetes,one of the world's top ten diseases,is known for its high mortality and complication rates and low cure rate.Prediabetes precedes the onset of diabetes,during which effective treatment can reduce diabetes ris...
关键词：PREDIABETES Glucagon-like peptide agonists Sodium–glucose cotransporter 2 inhibitors Vitamin D Chinese herbal medicines 
Emerging therapeutic options for non-alcoholic fatty liver disease:A systematic review
《World Journal of Hepatology》2023年第8期1001-1012,共12页Jasmine Tidwell Natalie Balassiano Anjiya Shaikh Mahmoud Nassar 
BACKGROUND Non-alcoholic fatty liver disease(NAFLD)has become a prevalent cause of chronic liver disease and ranks third among the causes of transplantation.In the United States alone,annual medical costs are approxim...
关键词：Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Cyclophilin inhibitors Fibroblast growth factor 21 analogs Dual peroxisome proliferator-activated receptor agonists Pan peroxisome proliferator-activated receptor agonists 
Small molecule-based immunomodulators for cancer therapy被引量：10
《Acta Pharmaceutica Sinica B》2022年第12期4287-4308,共22页Yinrong Wu Zichao Yang Kui Cheng Huichang Bi Jianjun Chen 
This work was supported by the National Natural Science Foundation of China(No.82173668);Scientific Research Project of High-Level Talents(No.C1034335,China)in Southern Medical University of China;Thousand Youth Talents Program(No.C1080094,China)from the Organization Department of the CPC Central Committee,China.
Immunotherapy has led to a paradigm shift in the treatment of cancer.Current cancer immunotherapies are mostly antibody-based,thus possessing advantages in regard to pharmacodynamics(e.g.,specificity and efficacy).How...
关键词：Cancer immunotherapy Small molecules IMMUNOMODULATORS INHIBITORS AGONISTS 
Finally, Some Reason for Hope in Proteinuric Kidney Disease
《Open Journal of Nephrology》2022年第3期241-248,共8页Devin Teehan Christopher Tyburski Geoffrey Teehan 
Background: After years of predictable outcomes with limited tools to combat the ravages of proteinuric chronic kidney disease (CKD) associated with or without diabetes, exciting new options are available to slow the ...
关键词：Chronic Kidney Disease Sodium-Glucose Co-Transporter 2 Inhibitors Mineralocorticoid Agonists Angiotensin Receptor Blockers Angiotensin Converting Enzyme Inhibitors 
Non-alcoholic fatty liver disease:Epidemiology,pathophysiology and an update on the therapeutic approaches被引量：4
《Asian Pacific Journal of Tropical Biomedicine》2022年第3期99-114,共16页Rehab F.Abdel-Rahman 
Non-alcoholic fatty liver disease(NAFLD)denotes a spectrum of fatty liver disease in individuals without significant alcohol consumption.NAFLD is set to be the most common etiology of serious liver diseases in numerou...
关键词：Non-alcoholic fatty liver disease STEATOSIS Insulin sensitizers Glucagon-like peptide-1 analogues Dipeptidyl peptidase-4 inhibitors Farnesoid X receptor agonists 
Repositioning of dipeptidyl peptidase-4 inhibitors and glucagon like peptide-1 agonists as potential neuroprotective agents被引量：4
《Neural Regeneration Research》2019年第5期745-748,共4页Shaker A.Mousa Bassam M.Ayoub 
Repositioning of dipeptidyl peptidase-4 inhibitors and glucagon like peptide-1 receptor agonists is a breakthrough in the field of neural regeneration research increasing glucagon like peptide-1 bioavailability, hence...
关键词：REPOSITIONING DPP-4 INHIBITORS GLP-1RA neural regeneration blood-brain barrier Parkinson’s DISEASE Alzheimer’s DISEASE diabetic retinopathy 
Crosstalk between gut microbiota and antidiabetic drug action被引量：12
《World Journal of Diabetes》2019年第3期154-168,共15页Yevheniia Kyriachenko Tetyana Falalyeyeva Oleksandr Korotkyi Nataliia Molochek Nazarii Kobyliak 
Type 2 diabetes (T2D) is a disorder characterized by chronic inflated blood glucose levels (hyperglycemia), at first due to insulin resistance and unregulated insulin secretion but with tendency towards global spreadi...
关键词：Type 2 diabetes Gut microbiota Metformin Α-GLUCOSIDASE INHIBITORS Glucagon-like peptide-1 AGONISTS PEROXISOME proliferator-activated receptors γ AGONISTS Dipeptidyl peptidase-4 INHIBITORS Sodium/glucose COTRANSPORTER INHIBITORS 
Treatment of type 2 diabetes, lifestyle, GLP1 agonists and DPP4 inhibitors被引量：2
《World Journal of Diabetes》2014年第5期636-650,共15页Gerald H Tomkin 
In recent years the treatment focus for type 2 diabetes has shifted to prevention by lifestyle change and to more aggressive reduction of blood sugars during the early stage of treatment. Weight reduction is an import...
关键词：Type 2 diabetes LIFESTYLE modification Dipeptidyl PEPTIDASE 4 INHIBITORS Glucagon-like peptide-1 AGONISTS INSULIN 
Novel and emerging diabetes mellitus drug therapies for the type 2 diabetes patient被引量：3
《World Journal of Diabetes》2014年第3期305-315,共11页Charmaine D Rochester Oluwaranti Akiyode 
Type 2 diabetes mellitus is a metabolic disorder of deranged fat, protein and carbohydrate metabolism resulting in hyperglycemia as a result of insulin resistance and inadequate insulin secretion. Although a wide vari...
关键词：Type 2 diabetes mellitus Sodium dependent glucose co-transporter 2 inhibitors 11β -Hydroxysteroid dehydrogenase type 1 inhibitors Glycogen phosphorylase inhibitors Protein tyrosine phosphatase 1B inhibitors G protein-coupled receptor agonists Glucokinase activators 
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