partly supported by Grant-in-Aid for Scientific Research on Innovative Areas funding from the Ministry of Education,Culture,Sports,Science,and Technology(MEXT)KAKENHI(No.22H04677 to KO);a grant from the Japan Society for the Promotion of Science KAKENHI(No.20K09543 to ST,No.20K07228 to KK,and No.19KK0183 to KO);the Takeda Science Foundation(2021 to KK).
Mouse spermatogenesis entails the maintenance and self-renewal of spermatogonial stem cells(SSCs),which require a complex web-like signaling network transduced by various cytokines.Although brain-derived neurotrophic ...
This work was supported by the National Key Research and Development Program of China(No.2022YFC2702700);the National Natural Science Foundation of China(No.82171597);Clinical Research Plan of Shanghai Hospital Development Center(No.SHDC2020CR3077B).
The regulation of spermatogonial proliferation and apoptosis is of great significance for maintaining spermatogenesis.The single-cell RNA sequencing(scRNA-seq)analysis of the testis was performed to identify genes upr...
This work was supported by the Ministry of Science and Technology of the People’s Republic of China(NO.2014CB943103);the National Natural Science Foundation of China(No.31671203 and NO.31471104);the Science and Technology Commission of Shanghai Municipality(NO.17JC1420100).
Spermatogonial development is a vital prerequisite for spermatogenesis and male fertility.However,the exact mechanisms underlying the behavior of spermatogonia,including spermatogonial stem cell(SSC)self-renewal and s...
the grants from the National Key Research and Development Program of China (Project No. 2016YFC1000200);the National Natural Science Foundation of China (Project No. 31472054).
While hallmarks of rodent spermatogonia stem cell biomarkers' heterogeneity have recently been identified, their stage and subset distributions remain unclear. Furthermore, it is currently difficult to accurately iden...
This work was supported by the National Natural Science Foundation of China (Number 31371174), the Natural Science Foundation of Jiangsu Province, China (Number BK20131230), and the Postgraduate Research and Practice Innovation Program of Jiangsu Province, China (KYCX17-1893). We thank Dr. Wilkinson (University of California, USA) for kindly providing Rhox 10 antibody.
To clarify the functions and mechanism of stimulated by retinoic acid gene 8 (Stra8) in spermatogenesis, we analyzed the testes from Stra8 knockout and wild-type mice during the first wave of spermatogenesis. Compar...
The H2-receptor antagonist cimetidine is an antiulcer drug also used for the treatment of cancer due to its antiangiogenic effect. However, this drug has caused structural changes in the seminiferous tubules. Vitamin ...
Apoptosis is an integral part of the spermatogenic process, necessary to maintain a proper ratio of Sertoli to germ cell numbers and provide an adequate microenvironment to germ cells. Apoptosis may also represent a p...
Col la I (one of the subunit of collagen type I) is a collagen, which belongs to a family of extracellular matrix (ECM) proteins that play an important role in cellular proliferation and differentiation. However, ...
Establishment of an in vitro system that allows the development of testicular germ cells to sperm will be valuable for studies of spermatogenesis and future treatments for male infertility. In the present study, we de...
Acknowledgment This work was supported by the National Natural Science Foundation of China (No. 30200195). We thank Dr Hai-Bin Wang for taking photographs and Dr Su-Hui Wu (Henan Normal University, China) for statistical analysis. We thank the faculty of Huanghuai University for supporting Dr En-Zhong Li.
Aim: To investigate whether estrogen stimulates the proliferation of spermatogonia or induces spermatogenesis in cryptorchid mice. Methods: Mice were surgically rendered cryptorchid, then treated with different dose...