FERROPORTIN

作品数:31被引量:106H指数:6
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相关领域:医药卫生更多>>
相关作者:段相林常彦忠林清王玮蒋丽更多>>
相关机构:青岛大学河北师范大学浙江大学中国科学院大学更多>>
相关期刊:《Acta Pharmacologica Sinica》《生理科学进展》《World Journal of Gastroenterology》《北京中医药》更多>>
相关基金:国家自然科学基金河北省自然科学基金国家重点基础研究发展计划泰国研究基金更多>>
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基于TLR/NF-κB信号通路的异功散治疗慢性病贫血的机制研究
《北京中医药》2024年第10期1100-1105,共6页姜一陵 季玉婷 郑秦 石岭 张爱萍 吴志豪 徐海涛 张瑞峰 胡洁 罗梅宏 
国家自然科学基金项目(82104778,81774271,81804021);上海市科学技术委员会“科技创新行动计划”医学创新研究项目(20Y21900400);上海市卫生健康委员会“十四五”中医特色专科和中医急诊能力提升孵化项目(ZYTSZK2-14);上海市中医药(临床类)重点学科(传统学科类)项目(shzyyzdxk-2024208);宝山区卫生健康委优青(育才)计划资助项目(BSWSYC-2003-01);宝山区医学重点学(专)科建设项目(BSZK-2023-Z01);上海市宝山区科学技术委员会医学卫生项目(21-E-23);罗梅宏宝山区名中医传承工作室项目(BSMZYGZS-2024-04)。
目的 探讨异功散通过TLR/NF-κB信号通路治疗慢性病贫血(ACD)的作用及机制。方法 将60只C57BL/6小鼠分为空白组、模型组、异功散(YGS)组、促红细胞生成素(EPO)组,建立酵母多糖诱导的脓毒症(ZIGI)炎性贫血小鼠模型,在酵母聚糖A(Zymosan A...
关键词:慢性病贫血 TLR4/NF-κB信号通路 hepcidin-ferroportin轴 异功散 
逍遥散及其拆方对Erastin诱导的LO-2肝细胞系铁死亡的影响
《湖南中医药大学学报》2024年第9期1601-1607,共7页曹梦醒 李勇 阙任烨 
国家自然科学基金项目(81873157,81573775);上海市科学技术委员会科研计划项目(19YF1445200);上海市虹口区卫生健康委员会中医药科研基金项目(HKQGYQY-ZYY-2022-08)。
目的 探讨逍遥散及其拆方对Erastin诱导肝细胞铁死亡的影响及机制。方法 使用铁死亡诱导剂Erastin诱导肝细胞LO-2铁死亡,用逍遥散及各功效拆方(逍遥散去疏肝药组、逍遥散去健脾药组、逍遥散去养血药组)的含药血清进行干预,阳性对照药使...
关键词:逍遥散 铁死亡 Erastin hepcidin-ferroportin轴 BMP6/HJV/Smad4信号通路 丙二醛 过氧化活性氧 
A Revised Classification of Primary Iron Overload Syndromes
《Journal of Clinical and Translational Hepatology》2024年第4期346-356,共11页Yasuaki Tatsumi Motoyoshi Yano Shinya Wakusawa Hiroaki Miyajima Tetsuya Ishikawa Shinsaku Imashuku Atsuko Takano Wataru Nihei Ayako Kato Koichi Kato Hisao Hayashi Kentaro Yoshioka Kazuhiko Hayashi 
Background and Aims:The clinical introduction of hepcidin25(Hep25)has led to a more detailed understanding of its relationship with ferroportin(FP)and divalent metal transporter1 in primary iron overload syndromes(PIO...
关键词:ETHNICITY FERROPORTIN HEMOCHROMATOSIS Hepcidin25 Iron overload syndrome 
Chronic administration of triclosan leads to liver fibrosis through hepcidin-ferroportin axis-mediated iron overload
《Journal of Environmental Sciences》2024年第3期144-154,共11页Jing Liu Lecong Zhang Fang Xu Ping Zhang Yang Song 
supported by the National Natural Science Foundation of China (No.22166012);Guizhou Provincial Science and Technology Projects (No.[2020]1Z007)。
Triclosan(TCS)has been manufactured as an antibacterial compound for half a century.Currently,it is widely used in various personal care products;however,its potential adverse effects raise a lot of attention.Here,we ...
关键词:TRICLOSAN Iron metabolism HEPCIDIN HEPATOTOXICITY Liver fibrosis 
Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52被引量:1
《Journal of Pharmaceutical Analysis》2024年第1期86-99,共14页Shengyou Li Xue Gao Yi Zheng Yujie Yang Jianbo Gao Dan Geng Lingli Guo Teng Ma Yiming Hao Bin Wei Liangliang Huang Yitao Wei Bing Xia Zhuojing Luo Jinghui Huang 
supported by grants from the National Natural Science Foundation of China(Grant Nos.:82122043,81972052,81902213,82201537,and 81730065);the China Postdoctoral Science Foundation(Grant Nos.:2021M693946 and 2019M653967).
A major impedance to neuronal regeneration after peripheral nerve injury (PNI) is the activation of various programmed cell death mechanisms in the dorsal root ganglion. Ferroptosis is a form of programmed cell death ...
关键词:Ferroptosis UBA52 FERROPORTIN UBIQUITINATION HYDRALAZINE Peripheral nerve injury 
DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease被引量:9
《Neural Regeneration Research》2023年第1期194-199,共6页Chun-Bo Hu Hui Jiang Yin Yang Guo-Hua Wang Qiu-Hong Ji Zhong-Zheng Jia Li-Hua Shen Qian-Qian Luo 
funded by the National Natural Science Foundation of China, No. 81873924 (to QQL), No. 82171190 (to GHW);Nantong Science and Technology Project of China, No. MS22021010 (to LHS);High-level Innovation and Entrepreneurship Talents Introduction Program of Jiangsu Province of China (to QQL)
DL-3-n-butylphthalide(NBP)-a compound isolated from Apium graveolens seeds-is protective against brain ischemia via various mechanisms in humans and has been approved for treatment of acute ischemic stroke.NBP has sho...
关键词:cystine/glutamate antiporter solute carrier family 7 member 11 DL-3-n-butylphthalide ferritin light chain ferroportin 1 ferroptosis glutathione peroxidase 4 oxidative stress iron ROTENONE transferrin receptor 
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice被引量:1
《Acta Pharmacologica Sinica》2022年第7期1686-1698,共13页Peng-ju Yan Zhao-xiang Ren Zhi-feng Shi Chun-lei Wan Chao-jun Han Liu-shuai Zhu Ning-ning Li John LWaddington Xue-chu Zhen 
This work was supported by the National Natural Science Foundation of China(81973334,81773702);the Priority Academic ProgramDevelopment of the Jiangsu Higher Education Institutes(PAPD).
Chronic administration of methamphetamine (METH) leads to physical and psychological dependence. It is generally accepted that METH exerts rewarding effects via competitive inhibition of the dopamine transporter (DAT)...
关键词:METHAMPHETAMINE drug addiction conditioned place preference Clk1 dopamine transporter iron ferroportin 1 hypoxia-inducible factor-1α STRIATUM HIPPOCAMPUS 
铁泵蛋白Ferroportin生理功能及其调控机制研究进展被引量:4
《生命科学》2022年第7期754-777,共24页李大航 徐杉 蒋丽 苏韵星 闵军霞 王福俤 
国家重点研发计划(2018YFA0507801,2018YFA0507802);国家自然科学基金项目(31930057,31970689);中国博士后科学基金项目(2021M702797)。
铁泵蛋白(Ferroportin, FPN/SLC40A1)是目前哺乳动物中唯一已知的铁外排膜蛋白,在调控机体铁稳态代谢过程中发挥重要作用。近年,围绕FPN蛋白转运铁离子生理功能及其分子调控机制方面取得了令人瞩目的研究进展。FPN蛋白通过从细胞内向外...
关键词: 铁泵蛋白 铁调素 离子转运 血色病 
α-突触核蛋白高表达对PC12细胞ferroportin、铁调节蛋白1和铁调素表达的影响
《青岛大学学报(医学版)》2022年第3期341-344,共4页王雪 宓晓晴 宋宁 
国家自然科学基金面上项目(31871049)。
目的探讨PC12细胞高表达野生型(WT)α-突触核蛋白(α-Syn)对ferroportin(FPN)、铁调节蛋白1(IRP1)蛋白表达以及铁调素mRNA表达的影响。方法PC12细胞用基础培养液处理24 h(对照组)或用2 mg/L多西环素(DOX)处理24 h(DOX处理组)。采用免疫...
关键词:Α突触核蛋白 PC12细胞 转铁蛋白 铁调节蛋白质类 
The novel SLC40A1(T419I)variant results in a loss-of-function phenotype and may provide insights into the mechanism of large granular lymphocytic leukemia and pure red cell aplasia被引量:1
《Blood Science》2022年第1期29-37,共9页Hongfei Wu Xiang Ren Meili Ge Peiyuan Dong Shichong Wang Huiming Yi Xingxin Li Jiali Huo Xuan Zheng Mengying Gao Jinbo Huang Jing Zhang Min Wang Peng Jin Neng Nie Yingqi Shao Yizhou Zheng 
was supported by grants from the National Natural Science Foundation of China under grant numbers 81770119&81700120。
Variants in the solute carrier family 40 member 1(SLC40A1)gene are the molecular basis of ferroportin disease,which is an autosomal dominant hereditary hemochromatosis.Here,we present a patient with pure red cell apla...
关键词:Ferroportin disease Iron overload Large granular lymphocytic leukemia Pure red cell aplasia SLC40A1 variant 
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