supported by the National Key R&D Program of China(grant nos.2021YFF0701603 and 2022YFA1504302);the National Natural Science Foundation of China(grant nos.21925109,U22A20388,and 92256302);the Fundamental Research Funds for the Central Universities(grant nos.226-2023-00115 and 226-2022-00224);the College of Material Chemistry and Chemical Engineering,Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education,Hangzhou Normal University(grant no.KFJJ2023003).
Oxy-substituted planar chiral ferrocenes are of great importance in asymmetric synthesis and pharmaceuticals.However,enantioselective C–H activation of ferrocenes that form C–O bonds remains a huge challenge and has...
Financial support from the National Natural Science Foundation of China (grant nos.22025103,92256301,21831002,22271133,22101122,and 22201127);the National Key R&D Program of China (grant nos.2021YFF0701604 and 2021YFF0701704);New Cornerstone Science Foundation through the XPLORER PRIZE,Shenzhen Science and Technology Program (grant nos.KQTD20210811090112004 and JCYJ20220818100600001);Shenzhen Key Laboratory of Cross-Coupling Reactions (grant no.ZDSYS20220328104200001).
Enantioselective radical desymmetrization is a highly effective approach for rapidly creating enantioenriched molecules,introducing dramatically increased structural complexity from readily available prochiral or meso...
the National Key R&D Program of China(grant no.2021YFA1500200);the National Natural Science Foundation of China(grant nos.92056108 and 92256303)for financial support.
A distinct class of C1-symmetric N-heterocyclic carbene(NHC)ligands possessing a chiral fused tetrahydroquinoline ring and a chiral N-arylmethyl group was designed and synthesized via an asymmetric catalytic synthesis...
We gratefully acknowledge funding from the Jiangsu Specially Appointed Professor Plan,National Natural Science Foundation of China(grant no.22071111);Natural Science Foundation of Jiangsu Province of China(grant no.BK20201368).
The development of new catalytic enantioselective access to stereogenic CF_(3)-containingmolecules is of great interest for expediting the discovery of lead compounds that remain challenging.Specifically,enantioselect...
the National Natural Science Foundation of China(Nos.21790332,91956000,22188101);the Fundamental Research Funds for the Central Universities,and the Haihe Laboratory of Sustainable Chemical Transformations for their financial support.
Herein we report a method for highly diastereoselective and enantioselective nickel-catalyzed reductive coupling of imines and unactivated alkenes.A monodentate chiral spiro phosphoramidite ligand is the key to contro...
supported by National Natural Science Foundation of China(grant no.22171079);the Natural Science Foundation of Shanghai(grant no.21ZR1480400);the Shanghai Rising-Star Program(grant no.20QA1402300);the Shanghai Municipal Science and Technology Major Project(grant no.2018SHZDZX03);the Program of Introducing Talents of Discipline to Universities(grant no.B16017);the Fundamental Research Funds for the Central Universities and the China Postdoctoral Science Foundation(grant no.2021M701197).
The facile construction of chiral quaternaryα-alkenylated pyrrolidinones is a long-term challenge in organic synthesis.The asymmetric difunctionalization of 1,3-dienes represents the most compelling tool for assembli...
supported by the National Key R&D Program of China(grant no.2018YFE0126800);the National Natural Science Foundation of China(grant nos.21831005,91856106,21991112,and 22071150);the Shanghai Municipal Education Commission(grant no.201701070002E00030);the China Postdoctoral Science Foundation(grant no.2021M692058).
By adjusting the bond angle and stereocontrol substituent of the chiral bicyclic imidazole catalysts,direct enantioselective C-acetylation of indolones and their sequencial pattern have been successfully developed.Ind...
the National Natural Science Foundation of China(NSFC)(nos.21871178,22071149,21901158,21702135)and the STCSM(no.19JC1430100)for their financial support.
Enantioselective intermolecular three-component oxysulfenylations of alkenes with phenols and alcohols as O-nucleophiles were achieved using chiral BINAM-derived sulfide/phosphoric acid as the cocatalyst.Notably,chira...
grant fromNSFC(nos.21821002,21772222,and 91956112),CAS(no.XDB20000000);Science and Technology Commission of Shanghai Municipality(nos.18JC1415600 and 20JC1417100).
The synergistic use of transition metal catalysis and electrochemistry is an attractive strategy for oxidative site-selective C–H functionalization since the use of stoichiometric chemical oxidants can be avoided and...
the National Natural Science Foundation of China(nos.21790330 and 91956000)and the“111”Project(no.B06005)of the Ministry of Education of China for financial support.
The regio-and enantioselective functionalization of 1,3-dienes has become a powerful tool for the synthesis of allylic compounds,yet it remains a challenge for aliphatic dienes.Herein,we report a nickel-catalyzed asym...