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SUPPRESSES: 作品数：640被引量：3146H指数：21; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：李建磊郭静杨雅阁王书奎李修成更多>>; 相关机构：北京大学复旦大学澳门科技大学武汉大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>

Overexpression of Circ-Astn1 Suppresses Hyperglycemia-Induced Endothelial Cell Damage via the miR-138-5p/SIRT1 Axis: 《Current Medical Science》2025年第1期93-103,共11页Hong-bin Yu Li-yun Wang Xiao-ning Yan Xue-yan Wu Jian-long Wu Da-wei Liu Si-yang Liu; supported by grants from the National Natural Science Foundation of China(No.81770483);Shanghai Tenth Hospital’s improvement plan for NSFC(No.04.03.17.070).; Objective To elucidate the regulatory mechanism of circRNAs in diabetic retinopathy.Methods Next-generation sequencing(NGS)was employed to identify circRNAs that are abnormally expressed in endothe-lial progenitor cel...; 关键词：Circ-Astn1 Endothelial cell HYPERGLYCEMIA miR-138-5p SIRT1

Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1: 《Current Medical Science》2024年第1期223-231,共9页Hong-li ZHANG Na LI Lin DONG Hong-xia MA Mo-chi YANG; Objective Retinoblastoma(RB)is a prevalent type of eye cancer in youngsters.Prospero homeobox 1(Prox1)is a homeobox transcriptional repressor and downstream target of the proneural gene that is relevant in lymphatic,h...; 关键词：Proxl NOTCH1 retinoblastoma cells PROLIFERATION drug resistance

Liraglutide Suppresses Myocardial Fibrosis Progression by Inhibiting the Smad Signaling Pathway被引量：2: 《Current Medical Science》2023年第5期955-960,共6页Wen SUN Hong MI De-ying HE Wen LI Yi-yan SONGYANG; supported by grants from the Natural Science Foundation of Hubei Province(No.2022CFB671);Health Research Project of Hubei Province(No.WJ2023F020);Hubei Province Key Laboratory Open Project(No.2021KFY023).; Objective Liraglutide is a commonly used hypoglycemic agent in clinical practice,and has been demonstrated to have protective effects against the development of cardiovascular disease.However,its potential role in myo...; 关键词：LIRAGLUTIDE myocardial fibrosis TGFβl SMAD

Maslinic Acid Suppresses High Glucose-induced Inflammation by Epigenetically Inhibiting TXNIP Expression被引量：6: 《Current Medical Science》2022年第6期1213-1219,共7页Lin WANG Yi-fu FAN Bing-rui LI Wen-hui SUN Li-na WANG; supported by grants from the National Natural Science Foundation of China(No.81804053);the Natural Science Foundation of Shanghai Science and Technology Commission(No.16ZR1401000).; Objective Hyperglycemia-induced inflammation and subsequent endothelial injuries ultimately lead to the pathogenesis of cardiovascular diseases associated with high mortality,such as atherosclerosis.Maslinic acid(MA)i...; 关键词：maslinic acid INFLAMMATION N 6-methyladenosine RNA demethylase ALKBH5

Overexpression of MiR-633 Suppresses the Tumorigenicity of Gastric Cancer Cells and Induces Apoptosis by Targeting MAPK1被引量：3: 《Current Medical Science》2022年第5期1033-1045,共13页Hai-long LI Yao-hui SONG Zheng-ping DU Yong-hua HU Zhuan-xiong WANG Xi CHEN Xing-mei LU Ying-xia CHEN Yong-qiang DUAN Xiang-dong ZHU; supported by grants from Natural Science Foundation of Gansu Province(No.20JR5RA189 and No.17JR5RA169);the Foundation of the fundamental scientific research funds for colleges and universities in Gansu Province[No.(2014)63-15];the National Natural Science Fundation of China(No.81760830).; Objective MicroRNA(miRNA/miR)-633 is dysregulated in several types of cancers and is involved in tumorigenesis.However,the function and role of this miRNA in gastric cancer(GC)are not fully understood.The aim of the p...; 关键词：miR-633 gastric cancer APOPTOSIS metastasis mitogen-activated protein kinase 1

Lentivirus-Mediated Short Hairpin RNA for Follistatin Downregulation Suppresses Tumor Progression in Hypopharyngeal Carcinoma被引量：1: 《Current Medical Science》2022年第4期832-840,共9页Liang GE Shao-feng LIU; supported by the Project of Young and Middle-aged Scientific Research Fund of Wannan Medical College(No.WK2019F11).; Objective:Follistatin(FST)inhibits the action of activin by interfering with the binding of activin to its receptor.Although the prognostic value of FST in various cancers has been investigated previously,studies rare...; 关键词：FOLLISTATIN hypopharyngeal carcinoma migration INVASION PROLIFERATION apoptosis

BOPl Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation被引量：5: 《Current Medical Science》2021年第2期287-296,共10页Yu-peng YANG Rui-huan QIN Jun-jle ZHAO Xin-yu QIN; supported by National Natural Science Foundation of China(No.31670806)。; Block of proliferation 1(BOP1)is a key protein involved in ribosome maturation and affects cancer progression.However,its role in gastric cancer(GC)remains unknown.This study aimed to explore the expression of BOPI in...; 关键词：gastric cancer block of proliferation 1 cell proliferation P53

Cornel Iridoid Glycoside Suppresses Hyperactivity Phenotype in rTg4510 Mice through Reducing Tau Pathology and Improving Synaptic Dysfunction被引量：3: 《Current Medical Science》2020年第6期1031-1039,共9页Deng-lei MA Yi LUO Rui HUANG Zi-run ZHAO Li ZhANG Ya-li LI Qi WANG Lin LI Lan ZhANG; This research was supported by National Natural Science Foundation of China(Nos.81473373,81874351,81673406);Capital Science and Technology Leading Talent Training Project(No.Z 191100006119017);Beijing Hospitals Authority Ascent Plan(No.DFL20190803);Cultivation Fund of Capital Medical University(No.PYZ19134).; rTg4510 mice are transgenic mice expressing P301L mutant tau and have been developed as an animal model of tauopathies including Alzheimer’s disease(AD).Besides cognitive impairments,rTg4510 mice also show abnormal h...; 关键词：cornel iridoid glycoside rTg4510 mouse HYPERACTIVITY TAUOPATHY Alzheimer’s disease tau phosphorylation synaptic function

Polysaccharide from Angelica Sinensis Suppresses Inflammation and Reverses Anemia in Complete Freund's Adjuvant-induced Rats被引量：20: 《Current Medical Science》2020年第2期265-274,共10页Ming-ming LI Yu ZHANG Jun WU Kai-ping WANG; This project was supported by Natural Science Foundation of Hubei Province(No.2018CFB488).; The antinlammatory and antianemic activities of Angelica sinensis polysaccharide(ASP)isolated from roots of Angelica sinensis(AS)was investigated in a complete Freund's adjuvant(CFA)-induced arthritic rat model.It was...; 关键词：POLYSACCHARIDE Angelica sinensis ARTHRITIS INFLAMMATION ANEMIA

Bcl6 Suppresses Cardiac Fibroblast Activation and Function via Directly Binding to Smad4被引量：2: 《Current Medical Science》2019年第4期534-540,共7页Jian NI Qing-qing WU Hai-han LIAO Di FAN Qi-zhu TANG; Bcl6,a critical pro-oncogene of human B-cell lymphomas,can promote tumor progress.Previous studies have found that Bcl6 participates in hypoxia injury in cardiomyocytes.However,the effect of Bcl6 on cardiac fibroblast...; 关键词：BCL6 cardiac FIBROBLAST TRANSFORMING growth factor β1 SMAD4

SUPPRESSES