EPILEPTOGENESIS

作品数：29被引量：56H指数：5
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相关期刊：《Chinese Medical Journal》《Neuroimmunology and Neuroinflammation》《Acta Epileptologica》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》更多>>
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Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy被引量：1
《Neuroscience Bulletin》2024年第5期564-576,共13页Yujia Shen Yiwei Gong Xiaoli Da Shajing Gao Shuo Zhang Minjuan Sun Yuanzhi Yang Xiaoyun Qiu Menghan Li Yang Zheng Fan Fei Yi Wang Zhong Chen Cenglin Xu 
supported by grants from the National Natural Science Foundation of China(U21A20418 and 82173796);the Natural Science Foundation of Zhejiang Province(LD22H310003);the Research Project of Zhejiang Chinese Medical University(2023JKZDZC04).
Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the primary focus.It is one of the major resultants of pharmacoresistance and...
关键词：Secondary epileptogenesis Low-frequency stimulation SUBICULUM Temporal lobe epilepsy 
The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy被引量：1
《Neuroscience Bulletin》2024年第5期621-634,共14页Xiuxiu Liu Ying Zhang Yanming Zhao Qian Zhang Feng Han 
supported by the National Key Research and Development Program of China(81930103);the National Natural Science Foundations of China(82104162);the Natural Science Foundation of Jiangsu Province(BK20210539).
Epilepsy is a multifaceted neurological syndrome characterized by recurrent,spontaneous,and synchronous seizures.The pathogenesis of epilepsy,known as epileptogenesis,involves intricate changes in neurons,neuroglia,an...
关键词：EPILEPTOGENESIS Neurovascular unit Molecular mechanisms Drug targets 
The Contributions of Thrombospondin-1 to Epilepsy Formation被引量：1
《Neuroscience Bulletin》2024年第5期658-672,共15页Yao Cheng Yujie Zhai Yi Yuan Qiaoyun Wang Shucui Li Hongliu Sun 
supported by the Natural Science Foundation of Shandong Province(ZR2021MH034 and ZR2022MH059);the National Natural Science Foundation of China(81573412).We’d like to thank Editage for English language editing.
Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory networks.Abnormal synaptogenesis plays a vital role in the formation of...
关键词：Thrombospondin-1 EPILEPTOGENESIS SYNAPTOGENESIS HYPEREXCITABILITY 
Akt Inhibitor Perifosine Prevents Epileptogenesis in a Rat Model of Temporal Lobe Epilepsy被引量：9
《Neuroscience Bulletin》2018年第2期283-290,共8页Feng Zhu Jiejing Kai Linglin Chen Meiling Wu Jingyin Dong Qingmei Wang Ling-Hui Zeng 
supported by the National Natural Science Foundation of China(81371429);the Public Welfare Technology Application Research Project of Zhejiang Province,China(2016C33211);the Science and Technology Commission of Hangzhou Municipality,Zhejiang Province,China(20140633B37and 20160533B73)
Accumulating data have revealed that abnormal activity of the mTOR(mammalian target of rapamycin)pathway plays an important role in epileptogenesis triggered by various factors. We previously reported that pretreatmen...
关键词：Akt-mTOR signaling PERIFOSINE Kainic acid Spontaneous seizure Cognitive function 
Generation of Febrile Seizures and Subsequent Epileptogenesis被引量：6
《Neuroscience Bulletin》2016年第5期481-492,共12页Bo Feng Zhong Chen 
supported by the National Natural Science Foundation of China (91332202 and 81503045)
Febrile seizures（FSs） occur commonly in children aged from 6 months to 5 years. Complex（repetitive or prolonged） FSs, but not simple FSs, can lead to permanent brain modification. Human infants and immature rodent...
关键词：Febrile seizures Epilepsy Epileptogenesis 
Early hypoactivity of hippocampal rhythms during epileptogenesis after prolonged febrile seizures in freely-moving rats被引量：2
《Neuroscience Bulletin》2015年第3期297-306,共10页Bo Feng Yang-Shun Tang Bin Chen Zheng-Hao Xu Yi Wang Deng-Chang Wu Hua-Wei Zhao Shi-Hong Zhang Zhong Chen 
supported by the National Natural Science Foundation of China (91332202, 81273506, 81273492);the Program for Zhejiang Leading Team of S&T Innovation, China (2011R50014)
Prospective and experimental studies have shown that individuals with early-life complex/prolonged febrile seizures （FSs） have a high incidence of temporal lobe epilepsy during adulthood, revealing a close relations...
关键词：febrile seizure seizure susceptibilityepilepsy hippocampal rhythms 
One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death被引量：9
《Neuroscience Bulletin》2013年第3期295-302,共8页Ling-Lin Chen Hang-Feng Feng Xue-Xia Mao Qing Ye Ling-Hui Zeng 
supported by grants from the National Nature Science Foundation of China (8107262);the Zhejiang Provincial Natural Science Foundation of China (Y2100417);the Foundation of Qianjiang Talents (QJD1002012);the Foundation of Health Department of Zhejiang Province for Outstanding Youths (2010)
Determining the minimal duration of status epilepticus （SE） that leads to the development of subsequent spontaneous seizures （i.e., epilepsy） is important, because it provides a critical timewindow for seizure int...
关键词：EPILEPTOGENESIS PILOCARPINE Fluoro-JadeB staining Timm staining Morris water maze 
Expression of connexin 30 and connexin 32 in hippocampus of rat during epileptogenesis in a kindling model of epilepsy被引量：1
《Neuroscience Bulletin》2012年第6期729-736,共8页Bijan Akbarpour Mohammad Sayyah Vahab Babapour Reza Mahdian Siamak Beheshti Ahmad Reza Kamyab 
Objective Understanding the molecular and cellular mechanisms underlying epileptogenesis yields new in- sights into potential therapies that may ultimately prevent epilepsy. Gap junctions （GJs） create direct interce...
关键词：connexin 30 connexin 32 HIPPOCAMPUS KINDLING 
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