SPECTROMETRY

作品数：461被引量：896H指数：12
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Influence of traditional Chinese medicines on the in vivo metabolism of lopinavir/ritonavir based on UHPLC-MS/MS analysis被引量：1
《Journal of Pharmaceutical Analysis》2022年第2期270-277,共8页Linlin Li Xinxiang Yu Dongmin Xie Ningning Peng Weilin Wang Decai Wang Binglong Li 
supported by the Development Plan of Science and Technology of Traditional Chinese Medicine in Shandong Province(Grant No.:2019e0350);the Development Plan of Medical and Health Technology in Shandong Province(Grant No.:2018WS133).
A fast,reliable,and cost-effective liquid chromatography-tandem mass spectrometry method was established to determine the effects of the traditional Chinese medicine employed to treat coronavirus disease 2019,namely,L...
关键词：Lopinavir/ritonavir Combination of Chinese and western medicine Drug-drug interaction Ultra high-performance liquid chromatography-tandem mass SPECTROMETRY PHARMACOKINETICS COVID-19 
Comparison of pharmacokinetics of different oral Panax notoginseng saponins using ultra-high performance liquid mass spectrometry被引量：2
《Journal of Traditional Chinese Medical Sciences》2021年第1期90-98,共9页Huichao Wu Huimin Liu Shouyin Du Jie Bai Yang Lu Lin Zhang 
This workwas financially supported by the National Science and Technology Major Project for Essential Drug Research and Development(No.2014ZX09301306-009);the National Science and Technology Major Project for Essential Drug Research and Development(No.2014ZX09301306-008).
Objective:To discuss and compare the plasma pharmacokinetics after three oral Panax notoginseng saponin(PNS)administrations in beagle dogs.PNS is the main active ingredient of the traditional Chinese medicine(TCM)Pana...
关键词：Ultra-high performance liquid mass SPECTROMETRY Panax notoginseng saponin preparation Soft capsule Hard capsule Comparison of pharmacokinetics 
Review of the diagnosis of gastrointestinal lanthanum deposition被引量：6
《World Journal of Gastroenterology》2020年第13期1439-1449,共11页Masaya Iwamuro Haruo Urata Takehiro Tanaka Hiroyuki Okada 
Lanthanum carbonate is used for treatment of hyperphosphatemia mostly in patients with chronic renal failure.Although lanthanum carbonate is safe,recently,lanthanum deposition in the gastrointestinal mucosa of patient...
关键词：LANTHANUM CARBONATE HYPERPHOSPHATEMIA GASTROINTESTINAL endoscopy LANTHANUM phosphate Scanning electron microscopy Energy-dispersive X-ray SPECTROMETRY 
Prediction of fibril formation by early-stage amyloid peptide aggregation
《Journal of Pharmaceutical Analysis》2020年第2期194-199,共6页Jiaojiao Hu Huiyong Sun Haiping Hao Qiuling Zheng 
supported by National Natural Science Foundation of China(GrantNos.81930109,81720108032,81430091,81421005,81703471,and 81603031);the Natural Science Foundation of Jiangsu Province(Grant No.BK20170740);the 111 project(Grant No.G20582017001);projects for Major New Drug Innovation and Development(Grant Nos.2018ZX09711001-002-003 and 2018ZX09711002-001-004);the State Key Laboratory of Natural Medicines at China PharmaceuticalUniversity,China(Grant No.SKLNMZZCX201817);a“Double-First Rate”project(Grant No.CPU2018GF09)。
Amyloid fibrils are found in systemic amyloidosis diseases such as Alzheimer's disease,Parkinson's disease,and type II diabetes.Currently,these diseases are diagnosed by observation of fibrils or plaques,which is an i...
关键词：Mass SPECTROMETRY AMYLOID FIBRIL EARLY-STAGE OLIGOMER Peptide AGGREGATION 
Mitochondrial Dysfunctions in Patients with Migraine
《Neuroscience & Medicine》2019年第4期339-353,共15页R. Alloush M. Haroun A. Shalash H. El-Fawal M. Hamdy 
Study Objectives: Migraine is a complex neurovascular disease and is believed to be due to a mixture of genetic and environmental factors. Study design: This was a cross-sectional observational prospective hospital ba...
关键词：MIGRAINE MIGRAINE with AURA MIGRAINE without AURA MITOCHONDRIAL Function Marker N-Acetyl-Aspartate (NAA) Magnetic Resonance Spectroscopy (MRS) and Liquid Chromatography-Mass SPECTROMETRY (LC/MS) 
Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease被引量：8
《World Journal of Gastroenterology》2019年第43期6404-6415,共12页Xing-Xin Yang Jia-Di Wei Jian-Kang Mu Xin Liu Feng-Jiao Li Yan-Qin Li Wen Gu Jing-Ping Li Jie Yu 
the National Natural Science Foundation of China,No.81660596;the National Natural Science Foundation of China,No.81760733;the Science and Technology Project of Yunnan China,No.2017FF117-013;the Science and Technology Project of Yunnan China,No.2016FD050;the Application and Basis Research Project of Yunnan China,No.201801CH00227
BACKGROUND Developing mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represent attractive strategies for therapy of nonalcoholic fatty liver disease(NAFLD).Polygonatum kin...
关键词：Metabolomics MITOCHONDRIA Multivariate statistical analysis Non-alcoholic FATTY liver POLYGONATUM kingianum Ultra-high performance liquid chromatography/mass SPECTROMETRY 
Metabolomic Profiling Differences among Asthma,COPD,and Healthy Subjects:A LC-MS-based Metabolomic Analysis被引量：4
《Biomedical and Environmental Sciences》2019年第9期659-672,共14页LIANG Ying GAI Xiao Yan CHANG Chun ZHANG Xu WANG Juan LI Ting Ting 
funded by the National Natural Science Foundation of China-Youth Fund Project [No.81400017,81700039,81800038];the National Natural Science Foundation of China Emergency Management Project [No.81641153]
Objective Asthma and chronic obstructive pulmonary disease(COPD)feature different inflammatory and cellular profiles in the airways,indicating that the cellular metabolic pathways regulating these disorders are distin...
关键词：ASTHMA Chronic OBSTRUCTIVE pulmonary disease Metabolomics Liquid CHROMATOGRAPHY Mass SPECTROMETRY 
Chemical Components of Achyranthes bidentata Leaves by Ultra High Performance Liquid Chromatography-Mass Spectrometry被引量：1
《Medicinal Plant》2019年第4期16-19,共4页Haiyang DONG Jinshuo MA Fulin YAN 
Supported by Key Scientific and Technological Research Project in Higher Education Institutions of Henan Province(17A350002);Project of National Natural Science Foundation of China(81172953)
[Objectives] To study the chemical components and relative content of Achyranthes bidentata leaves and provide a scientific basis for further development and utilization of A. bidentata leaves.[Methods] The chemical c...
关键词：Achyranthes bidentata LEAVES ULTRA high performance liquid chromatography-mass SPECTROMETRY (UHPLC-MS) Chemical components Inokosterone 
The Application of Electrospray Tandem Mass Spectrometry for <i>de novo</i>Sequencing of Reduced Insulins
《Journal of Biosciences and Medicines》2019年第7期135-150,共16页Xichen Gao 
Insulin, a blood glucose level mediator, is the mainstream therapeutic choice for diabetes patients. Since patent protection for many originator products is about to expire, manufacturers of follow-on insulin are dete...
关键词：Insulin Tandem Mass SPECTROMETRY ELECTROSPRAY de novo SEQUENCING 
Changes in mass spectrometry of proteins in patients with 1-bromopropane poisoning after treatment
《China Medical Abstracts(Internal Medicine)》2019年第2期76-76,共1页MIAO Rongming 
Objective To investigate the changes in mass spectrometryof proteins in patients with 1-bromopropane(1-BP) poisoning after treatment and their biologicalfunctions. Methods From May 2016 to December 2017,3 male patient...
关键词：CHANGES SPECTROMETRY of proteins 1-BROMOPROPANE POISONING AFTER TREATMENT 
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