云南高校图书馆联盟文献共享服务平台- CLAUSENAMIDE

CLAUSENAMIDE: 作品数：17被引量：34H指数：4; 导出分析报告; 相关领域：医药卫生理学更多>>; 相关作者：张均田段文贞更多>>; 相关机构：中国医学科学院北京协和医学院更多>>; 相关期刊：《Neural Regeneration Research》《中国药理通讯》《Acta Pharmacologica Sinica》《Chinese Medical Journal》更多>>; 相关基金：国家自然科学基金更多>>

Antioxidative and antiapoptotic effects of （＋）-clausenamide on acetaminophen-induced nephrotoxicity in mice: 《TMR Modern Herbal Medicine》2018年第3期127-135,共9页Hong-Min Yu Min Wang Zong-Chao Yu Yi-Fang Li Chun-Xin Huang Fang-Xuan Han Fan-Na Liu Rong-Rong He; This work was partly supported by TCM Modernization Program of Hainan Province （2015ZY01）, Natural Science Foundation of China （81573675 ＆ 81622050 ＆ 81673709）, Science and Technology Program of Guangzhou （201604046016 ＆ 201604020175） and Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine （20161070）.; Objective：（＋）-Clausenamide （（＋）-CLA）, the active ingredient of wampee, was isolated from the leaves of Clausena lansium （Lour.） Skeels. This study aimed to evaluate the protective potential of ...; 关键词：（＋）-Clausenamide ACETAMINOPHEN Kidney injury Oxidative stress Apoptosis pathway

Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells： an insight into the efflux-metabolism alliance被引量：1: 《中国药理学通报》2015年第B11期211-211,共1页; Aim The present study developed a CYP3A4-expressed Caco-2 monolayer model at which effects of the efflux-metabolism alliance on the transport and uptake of clausenamide（CLA） enantiomers as CYP3A4 substrates were inv...; 关键词：CLAUSENAMIDE ENANTIOMERS CYTOCHROME P450 3A4 P-GLYCOPROTEIN CACO-2 cell line

Recent advances in the study of(-)clausenamide:chemistry,biological activities and mechanism of action被引量：4: 《Acta Pharmaceutica Sinica B》2014年第6期417-423,共7页Shi-feng Chu Jun-tian Zhang; Clausenamide(clau)is one of seven novel compounds isolated from Clausena lansium(Lour)skeels.Clau is unusual in that it contains 4 chiral centers yielding 8 pairs of enantiomers.After identification of the configurati...; 关键词：(-)Clausenamide ENANTIOMERS COGNITION Alzheimer's disease pathology Tau High phosphorylation Synaptic plasticity

Novel Concise Synthesis of （-）-Clausenamide1被引量：1: 《Chinese Journal of Chemistry》2013年第3期344-348,共5页Di Liu Xiaoming Yu Liang Huang; A six-step synthesis of （-）-clausenamide is described. Optically pure （R,E）-1,3-diphenylallylic alcohol was ac-etylated and then subjected to an Ireland-Claisen rearrangement, giving the γ,δ-unsaturated acid, wh...; 关键词：（-）-clausenamide diastereoselective synthesis Ireland-Claisen rearrangement diastereoselectivebromo｜actonization bromo-c^-lactone aminolysis

Preparation of 4-and 6-desphenyl analogues of(-)-clausenamide and alternative synthesis of(+)-epi-clausenamide被引量：1: 《Chinese Chemical Letters》2011年第11期1261-1264,共4页Jian Jun Xue Yu Mei Zhou Xiao Ming Yu; supported by Natural Science Foundation of China(No30672530); 4- and 6-desphenyl analogues of（-）-clausenamide,6 and 7,were prepared in optical active form from commercially available D-pyroglutamic acid and the known racemic pyrrolidinone 13,respectively.In order to confirm th...; 关键词：（-）-Clausenamide Desphenyl analogue （＋）-epi-Clausenamide Synthesis

Selective 3-and 6-OH modification of (-)-clausenamide被引量：4: 《Chinese Chemical Letters》2011年第7期761-764,共4页Jian Jun Xue Xiao Ming Yu; financially supported by Natural Science Foundation of China(No.30672530); （-）-Clausenamide is a drug candidate under Phase I clinical trial for treatment of Alzheimer＇s disease （AD）. In order to elucidate the substituent related structure-activity relationship, six one-substituent modi...; 关键词：（-）-Clausenamide DERIVATIVES SYNTHESIS Alzheimer＇s disease

High performance liquid chromatographic separation of clausenamide enantiomers with chiral-AGP stationary phase被引量：1: 《Chinese Chemical Letters》2010年第7期860-863,共4页Yan Wang Qing Qiang Yao Mu Zou Wang; A method of high performance liquid chromatographic separation of clausenamide enantiomers with chiral-AGP（α_1-acid glycoprotein） stationary phases has been established.The absolute configurations of（-）clausenami...; 关键词：ENANTIOMERS （-）Clausenamide （＋）Clausenamide Chiral-AGP HPLC

Effect of clausenamide on hippocampal neuron apoptosis induced by sodium nitroprusside被引量：1: 《Neural Regeneration Research》2007年第1期33-37,共5页Yongjun Liu Qifeng Zhu; BACKGROUND： Aggregation of β-amyloid peptide （A β ）, excitatory intoxication, oxidation injury and inflammation reaction are generally regarded as the main pathogenesis for Alzheimer disease （AD）. （ - ） claus...; 关键词：HIPPOCAMPUS NEURON APOPTOSIS CLAUSENA LANSIUM

Different effects of nine clausenamide ennatiomers on liver glutathione biosynthesis and glutathione S-transferase activity in mice被引量：10: 《Acta Pharmacologica Sinica》2006年第8期1024-1028,共5页Yu-qun WU Li-de LIU Hua-ling WEI Geng-tao LIU; Aim： To study the effects of nine synthetic clausenamide with different stereo structures on liver glutathione （GSH） biosynthesis and glutathione S-transferase （GST） activity in mice. Methods： The nine test comp...; 关键词：CLAUSENAMIDE GLUTATHIONE γ-glutamylcysteine synthetase glutathione S-transferase

Study on the Intramolecular Cyclization through Openmg of Epoxide IV. Cyclization of N-Methyl-N-benzoylmethylene β-Methyl-α, β- epoxypropionamide in Aprotic and Protic Solvents: 《Chinese Chemical Letters》2006年第4期457-460,共4页Li Hong WANG Liang HUANG; Intramolecular cyclization of β -methyl substituted epoxide under aprotics （e.g. LDA in benzene） and protic conditions （e.g. LiOH in MeOH/H2O）both gave a mixture of β-,γ-, δ- and ε-lactam but in different ratio.; 关键词：Ring closure EPOXIDE clausenamide.

CLAUSENAMIDE