Background:Acute kidney injury (AKI) is a severe disease in critically ill patients.Neutrophil infiltration into kidney was associated with the development of AKI,and P-selectin may be involved in the process of ne...
Background Platelet P-selectin plays an important role in inflammation and contributes to thrombosis and hemostasis. Fibrinogen may take part in inflammation, thrombosis, and hemostasis via enhancement of platelet P-s...
Background Adhesion molecules play an important role in the development and progression of coronary atherosclerosis. The aim of this study was to compare concentrations of soluble forms of adhesion molecules in patien...
Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. Platelet activation may play an important role in pathologic progress in lung cancer. In this study, we aimed to clar...
Background Early local platelet activation after coronary intervention identifies patients at increased risk of acute stent thrombosis (AST). However, early changes in platelet activation in coronary circulation fol...
Background The release of Weibel-Palade Bodies (WPB) is a form of endothelial cell activation But the signal transduction pathway leading to WPB release is not yet defined We hypothesized that small G-protein ra...
This work was supported by grants from the Japanese Society for the Promotion of Science (No. JSPS-RFTF97100201) ; by the Hong Kong Baptist University Faculty Research Grant (No. HKBU/FRG/01-02/11-27).
Background llexonin A (IA), purified from the Chinese herbal medicine Maodongqing (Ilex pubescens Hook, et Am) has been commonly used in south China to treat thrombotic disorders. In this study, we aimed to study the ...
ThisworkwassupportedbytheScientificFoundationofMinistryofHealthofChina (No 98 2 2 83)andShanghaiNaturalScienceFoundation (N
To explore the effect of anti-P-selectin monoclonal antibody (mAb) on renal ischemia/reperfusion (I/R) injury in rats Methods Renal function, renal histopathological changes, plasma P-selectin levels and renal P-sel...
Objective To examine the relationship between P selectin expression and human glomerulonephritis. Methods P selectin expression was investigated in renal biopsies of glomerulonephritis patients (n=133) by imm...
Platelet plays an importent role in thromboembolic diseases. It is demonstrated that recurrent pulmonary embolism may cause pulmonary hypertention. In recent years,P-selectin(granule membrane protein,GMP40)was fou...