PRANLUKAST

作品数：13被引量：54H指数：6
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相关领域：医药卫生更多>>
相关作者：魏尔清俞月萍徐秋琴朱朝阳林东海更多>>
相关机构：浙江大学杭州师范大学厦门大学杭州医学院更多>>
相关期刊：《Acta Pharmacologica Sinica》《沈阳药科大学学报》《中国药理学通报》《中国药理通讯》更多>>
相关基金：国家自然科学基金浙江省自然科学基金更多>>
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Hippocampal CysLT1R knockdown or blockade represses LPS-induced depressive behaviors and neuroinflammatory response in mice被引量：3
《Acta Pharmacologica Sinica》2017年第4期477-487,共11页Jing-ran LIN Shun-chang FANG Su-su TANG Mei HU Yan LONG Arijit GHOSH Hong-bin SUN Ling-yi KONG Hao HONG 
This work was supported by grants from the National Natural Science Foundation of China （No 81273497; 81573413）, the Program for Changjiang Scholars and Innovative Research Team in University （No IRT1193）, and the Priority Academic Program Development of Jiangsu Higher Education Institutions （PAPD）.
Evidence suggests that neuroinflammation is involved in depression and that the cysteinyl leukotriene receptor 1 （CysLT1R） plays a potential pathophysiological role in several types of CNS disorders. Our previous s...
关键词：depression cysteinyl leukotriene receptor 1 LIPOPOLYSACCHARIDE FLUOXETINE PRANLUKAST hippocampus NEUROINFLAMMATION 
Nuclear translocation of cysteinyl leukotriene receptor I is involved in oxygen-glucose deprivation- induced damage to endothelial cells被引量：6
《Acta Pharmacologica Sinica》2012年第12期1511-1517,共7页San-hua FANG Ka-na LIN Xue-qin HUANG Yun-bi LU Wei-ping ZHANG Er-qing WEI 
Aim： Cysteinyl leukotriene receptor 1 （CysLT1 receptor） is located in epithelial cells, and translocates from the plasma membrane to the nucleus in a ligand-dependent manner. Here, we investigated whether CysLT1 re...
关键词：cysteinyl leukotriene receptor 1 nuclear translocation endothelial cell ischemic insult oxygen-glucose deprivation necro- sis apoptosis PRANLUKAST ZILEUTON 
Pranlukast对脑损伤保护作用的研究进展
《浙江预防医学》2009年第1期65-66,68,共3页张丽慧 赵建波 魏尔清 
关键词：脑损伤 神经保护作用 PRANLUKAST 神经元损伤 脑缺血 脑血管疾病 海马脑片 冷冻伤 兴奋性氨基酸 小鼠 小家鼠 局灶性 剂量依赖性 炎症介质 化学介质 大鼠 原代神经元 
Pranlukast attenuates oxygen-glucose deprivation-induced endothelial cell damage via inhibiting ROS production and NF-κB activation
《中国药理通讯》2008年第3期31-31,共1页San-Hua Fang Yu-Mei Yuan Fang Peng Wei-Ping Zhang Yun-Bi Lu Cheng-Tan Li Er-Qing Wei 
关键词：葡萄糖 内皮细胞 抑制作用 白三烯 
Pranlukast dose-and time-dependently protects against ischemic neuronal damage in the rat hippocampus
《沈阳药科大学学报》2008年第S1期55-55,共1页ZHANG Li-hui1,ZHAO Jian-bo1,YUAN Hui-ning1,HU Quan1,WEI Er-qing2(1.Department of Pharmacology,Hangzhou Normal University,Hangzhou 310036,China 2.Department of Pharmacology,Zhejiang University,Hangzhou 310058,China) 
Objective Our previous studies showed that the neuroprotective effect of pranlukast,a cysteinyl leukotriene receptor-1(CysLT1)antagonist,on global cerebral ischemia in rats.This study was performed to evaluate dose-an...
关键词：PRANLUKAST brain ISCHEMIA HIPPOCAMPUS NEUROPROTECTION 
Cysteinyl leukotriene receptor 1 partially mediates brain cryoinjury in mice被引量：4
《Acta Pharmacologica Sinica》2007年第7期945-952,共8页Qian DING San-hua FANG Yu ZHOU Li-hui ZHANG Wei-ping ZHANG Zhong CHEN Er-qing WEI 
Project supported by the National Natural Science Foundation of China(№ 30672449)
Aim： To determine whether the cysteinyl leukotriene receptor 1 （CysLT1 receptor） modulates brain cryoinjury and whether the CysLT1 receptor antagonist pranlukast exerts a time-dependent protective effect on cryoinj...
关键词：cysteinyl leukotriene receptor ANTAGONIST PRANLUKAST CRYOINJURY NEUROPROTECTION 
Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice被引量：7
《Acta Pharmacologica Sinica》2006年第12期1526-1536,共11页Qian DING Er-qing WEI Yan-jun ZHANG Wei-ping ZHANG Zhong CHEN 
Project supported by the National Natural Science Foundation of China(№30371637).
Aim： To determine whether cysteinyl leukotriene receptor 1 （CysLT1 receptor） is involved in N-methyl-D-aspartate （NMDA）-induced excitotoxic injury in the mouse brain. Methods： Brain injury was induced by NMDA mi...
关键词：cysteinyl leukotriene receptor EXCITOTOXICITY N-METHYL-D-ASPARTATE leukotriene receptor antagonist PRANLUKAST NMDA receptor antagonist KETAMINE 
Pranlukast reduces neutrophil but not macrophage/microglial accumu-lation in brain after focal cerebral ischemia in mice被引量：10
《Acta Pharmacologica Sinica》2006年第3期282-288,共7页Li-sheng CHU Er-qing WEI Guo-liang YU San-hua FANG Yu ZHOU Meng-ling WANG Wei-ping ZHANG 
Project supported by the National Natural Science Foundation of China(№30271498).
Aim： To determine whether pranlukast, a cysteinyl leukotriene receptor-1 antagonist, exerts an anti-inflammatory effect on focal cerebral ischemia in mice. Methods： Focal cerebral ischemia in mice was induced by per...
关键词：leukotriene receptor antagonist PRANLUKAST cerebral ischemia NEUROPROTECTION inflammation 
ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats被引量：12
《Acta Pharmacologica Sinica》2005年第4期435-440,共6页Li-huiZHANG Er-qingWEI 
Project supported by the National Natural Science Foundation of China(No 30271498).
Aim:To determine whether ONO-1078 (pranlukast),a potent cysteinyl leukotriene receptor 1 (CysLTI) antagonist,has an effect on N-methyl-D-aspartate (NMDA)- induced brain injury and vascular cell adhesion molecule-1 (VC...
关键词：leukotriene antagonists PRANLUKAST N-METHYLASPARTATE vascular cell adhesion molecule-1 NEUROTOXICITY brain injuries 
半胱氨酰白三烯受体拮抗剂pranlukast对小鼠局灶性脑缺血的治疗作用被引量：6
《中国药理学通报》2004年第7期758-761,共4页徐秋琴 魏尔清 俞月萍 张琦 张世红 朱朝阳 
国家自然科学基金资助项目;No 30271498;浙江省自然科学基金资助项目;No 39909
目的观察半胱氨酰白三烯受体拮抗剂pranlukast(ONO 1078)在小鼠局灶性脑缺血后的治疗作用。方法采用大脑中动脉阻塞造成小鼠持续性局灶性脑缺血,缺血后1、6、24h分别给小鼠腹腔注射pranlukast或依达拉奉,观察药物对缺血24、48h后的神经...
关键词：脑缺血 脑水肿 半胱氨酰白三烯受体拮抗剂 pranlukast{ONO-1078 4-氧-8-[对-(4-苯丁氧基)苯甲酰氨基]-2-(5-四唑基)-4H-1-苯并吡喃半水化合物} 依达拉奉(MCI186 3-甲基-1-苯基-2-吡唑啉-5-酮基) 
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