LYCORINE

作品数：8被引量：36H指数：3
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相关领域：医药卫生更多>>
相关作者：何艳刘静王淑玲胡济梁石洪凡更多>>
相关机构：中南大学宁夏大学中国科学院大学中国科学院更多>>
相关期刊：《Medicinal Plant》《Science China(Life Sciences)》《Science China Chemistry》《Virologica Sinica》更多>>
相关基金：国家自然科学基金国家教育部博士点基金福建省自然科学基金更多>>
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Lycorine derivative effectively inhibits the replication of coronaviruses both in vitro and in vivo被引量：1
《hLife》2024年第2期75-87,共13页Liang Shen Jianzhong Zhao Ying Xia Junjie Lu Jiali Sun Jian Tang Hui Xing Lijuan Yin Yang Yang Chunhua Wang 
supported by National Natural Science Foundation of China (82002192,32302218);General project of Natural Science Foundation of Hubei Province (2019CFA016,2022CFB539,2022CFD107);Young and Middle-aged Talents Project of Hubei Provincial Education Department (Q20222605);Tianjin Municipal Science and Technology Committee (21JCQNJC01410);China Postdoctoral Science Foundation (2021M702460);Science and Technology Plan (in the field of medical and health care)of Xiangyang (2022YL05B,2022YL12A).
The established and ongoing prevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and seasonal human coronaviruses(HCoV)like HCoV-OC43,HCoV-NL63,and HCoV-229E,pose a continuous threat to public heal...
关键词：BROAD-SPECTRUM antiviral drug lycorine derivative Ly-8 
Research Progress on Pharmacological Effects of Lycorine Hydrochloride
《Medicinal Plant》2023年第2期97-100,共4页Shan GAO Chenghao JIN 
Supported by the Talent Training Program for the Reform and Development of Local Colleges and University of the Central Government(2020GSP16)。
Lycoris radiata,a Chinese herbal medicine,is a plant of Amaryllidaceae family,which has the antidotal,expectorant,diuretic,emetic and insecticidal effects.Lycorine hydrochloride is an alkaloid extracted from the bulb ...
关键词：Lycorine hydrochloride Pharmacological effects Anti-fungus ANTI-VIRUS ANTI-TUMOR 
LC-MS/MS Analysis of Lycorine and Galantamine in Human Serum Using Pentafluorophenyl Column
《American Journal of Analytical Chemistry》2022年第9期300-313,共14页Chizuko Sasaki Tatsuo Shinozuka Kuniko Yoshimura Takaaki Maruhashi Yasushi Asari Fumiko Satoh 
Lycorine and galantamine are natural alkaloids found in Amaryllidaceae plants, such as narcissus. Narcissus leaves and roots are sometimes accidentally ingested because they resemble vegetables. Lycorine and galantami...
关键词：LYCORINE GALANTAMINE NARCISSUS Pentafluorophenyl Column LC/MS/MS 
In Vitro Inhibition of Alphaviruses by Lycorine
《Virologica Sinica》2021年第6期1465-1474,共10页Na Li Zhen Wang Rui Wang Zhe-Rui Zhang Ya-Nan Zhang Cheng-Lin Deng Bo Zhang Lu-Qing Shang Han-Qing Ye 
This work was supported by the National Key Research and Development Program of China(2018YFA0507201)。
Chikungunya virus(CHIKV) is a mosquito-borne alphavirus. As an emerging virus, CHIKV imposes a threat to public health. Currently, there are no vaccines or antivirals available for the prevention of CHIKV infection. L...
关键词：Chikungunya virus(CHIKV) ALPHAVIRUS LYCORINE ANTIVIRAL 
Lycorine inhibits the growth and metastasis of breast cancer through the blockage of STAT3 signaling pathway被引量：14
《Acta Biochimica et Biophysica Sinica》2017年第9期771-779,共9页Jian Wang Jie Xu Guoqiang Xing 
Signal transducer and activator of transcription 3 （STAT3） is involved in the growth and metastasis of breast cancer, and represents a potential target for developing new anti-tumor drugs. The purpose of this study ...
关键词：breast cancer LYCORINE STAT3 tumor growth METASTASIS 
Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway被引量：17
《Science China(Life Sciences)》2017年第4期417-428,共12页Xuexiang Ying Anling Huang Yajing Xing Liping Lan Zhengfang Yi Pingqing He 
supported by National Natural Science Foundation of China (81272463, 81472788);Major State Basic Research Development Program of China (2015CB910400)
Breast cancer is the most commonly diagnosed cancer type worldwide among women and more than 90% of patients die from tumor metastasis. Lycorine, a natural alkaloid, has been widely reported possessing potential effic...
关键词：metastasis inducing inhibited invasion paclitaxel blocking migration suppressed chemotherapy toxicity 
An LC-MS/MS Method for the Simultaneous Determination of Lycorine and Galanthamine in Rat Plasma and Its Application to Pharmacokinetic Study of Lycoris Radiata Extract in Rats
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2014年第6期861-868,共8页周欣 刘月彬 黄珊 刘莹 
supported by the Natural Science Foundation of Fujian Province of China(No.2013J01382)
A rapid, sensitive, and selective liquid chromatography-tandem mass spectrometry was developed for the simultaneous determination of lycorine and galanthamine, two major constituents in Lycoris radiata extract, in rat...
关键词：liquid chromatography-tandem mass spectrometry Lycoris radiata extract PHARMACOKINETIC ratplasma 
Multiple biological functions and pharmacological effects of lycorine被引量：14
《Science China Chemistry》2013年第10期1382-1391,共10页CAO ZhiFei YANG Ping ZHOU QuanSheng 
supported by Chinese Academy of Science Special National Strategic Leader Project(XDA01040200);Suzhou City Scientific Research Funds(SS201004 and SS201138);the priority academic program development of Jiangsu Higher Education Institutions(PAPD);Cultivation Base of State Key Laboratory of Stem Cell and Biomaterials built together by Ministry of Science and Technology and Jiangsu Province,Jiangsu Province’s Key Discipline of Medicine(XK201118);Research and Innovation Project for College Graduates of Jiangsu Province(CXZZ13_0824)
Lycorine is the major active component from the amaryllidaceae family plant Lycoris radiate,a represent traditional Chinese medicinal herb,and is one of the typical alkaloids with pyrrolophenanthridine nucleus core.Ly...
关键词：traditional Chinese medicinal herbs LYCORINE ANTI-CANCER ANTI-VIRUS ANGIOGENESIS NEOVASCULARIZATION 
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