ALPHAVIRUS

作品数：9被引量：11H指数：2
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相关领域：医药卫生更多>>
相关作者：王丽杜航管雪婷姜艳平李一经更多>>
相关机构：中国科学院大学东北农业大学中国农业科学院哈尔滨兽医研究所更多>>
相关期刊：《Virologica Sinica》《Open Journal of Rheumatology and Autoimmune Diseases》《淡水渔业》《hLife》更多>>
相关基金：国家自然科学基金国家科技支撑计划更多>>
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A high throughput antiviral screening platform for alphaviruses based on Semliki Forest virus expressing eGFP reporter gene
《Virologica Sinica》2023年第4期585-594,共10页Yu-Jia Shi Jia-Qi Li Hong-Qing Zhang Cheng-Lin Deng Qin-Xuan Zhu Bo Zhang Xiao-Dan Li 
supported by the Creative Research Group Program of Natural Science Foundation of Hubei Province (2022CFA021);National Natural Science Foundation of China (81702005).
Alphaviruses,which contain a variety of mosquito-borne pathogens,are important pathogens of emerging/reemerging infectious diseases and potential biological weapons.Currently,no specific antiviral drugs are available ...
关键词：ALPHAVIRUS Semliki Forest virus Reporter virus High throughput screening INHIBITOR 
Structural basis of Semliki Forest virus entry using the very-low-density lipoprotein receptor
《hLife》2023年第2期124-136,共13页Ying Li Zhennan Zhao Sheng Liu Haichen Wang Junqing Sun Yan Chai Jingya Zhou Yinuo Wang Yi Shi Hao Song George Fu Gao 
supported by the National Natural Science Foundation of China (82072290,82122040,and 32100129);supported by CAS Project for Young Scientists in Basic Research (YSBR-010);the Youth Innovation Promotion Association CAS (Y2021033).
Alphaviruses are a group of important viruses that cause significant diseases in humans.Among them,Semliki Forest vi-rus(SFV)not only causes symptoms such as joint pain but also infects neuron cells and induces enceph...
关键词：ALPHAVIRUS Semliki Forest virus very-low-density lipoprotein receptor cryo-electron microscopystruc-ture RECEPTOR viral entry 
In Vitro Inhibition of Alphaviruses by Lycorine
《Virologica Sinica》2021年第6期1465-1474,共10页Na Li Zhen Wang Rui Wang Zhe-Rui Zhang Ya-Nan Zhang Cheng-Lin Deng Bo Zhang Lu-Qing Shang Han-Qing Ye 
This work was supported by the National Key Research and Development Program of China(2018YFA0507201)。
Chikungunya virus(CHIKV) is a mosquito-borne alphavirus. As an emerging virus, CHIKV imposes a threat to public health. Currently, there are no vaccines or antivirals available for the prevention of CHIKV infection. L...
关键词：Chikungunya virus(CHIKV) ALPHAVIRUS LYCORINE ANTIVIRAL 
Visualization of the Oncolytic Alphavirus M1 Life Cycle in Cancer Cells
《Virologica Sinica》2021年第4期655-666,共12页Jia Dan Lin Nie Xudong Jia Cuiying Xu Jing Cai Yuan Lin Jun Hu Wenbo Zhu Yinyin Li Dong Chen Ying Liu Cheng Hu Guangmei Yan Jiankai Liang Qinfen Zhang 
This research was supported by the Science and Technology Program of Guangzhou(201707020003);the Pioneering Talents Project of Guangzhou Development Zone,Guangdong Province(CY2018-012);the Guangzhou People's Livelihood Science and Technology Tackling Key Project(201803010113);the Young Teacher Training Program of Sun Yat-sen University(20ykpy22);the National Natural Science Foundation of China(No.81802536).
Oncolytic alphavirus M1 has been shown to selectively target and kill cancer cells,but cytopathic morphologies induced by M1 virus and the life cycle of the M1 strain in cancer cells remain unclear.Here,we study the k...
关键词：Oncolytic virus M1 ALPHAVIRUS Electron microscopy Life cycle of virus 
Correction to:Visualization of the Oncolytic Alphavirus M1 Life Cycle in Cancer Cells
《Virologica Sinica》2021年第4期830-831,共2页Jia Dan Lin Nie Xudong Jia Cuiying Xu Jing Cai Yuan Lin Jun Hu Wenbo Zhu Yinyin Li Dong Chen Ying Liu Cheng Hu Guangmei Yan Jiankai Liang Qinfen Zhang 
Correction to:Virologica Sinica(2021)https://doi.org/10.1007/s12250-020-00339-7 In the original version of Fig.6,published on January 22,2021,the names of image panels(row 2 to row 5)were mislabeled during figure layo...
关键词：ALPHA Cancer corrected 
Drug Therapeutic in the Subacute and Chronic Phase of Chikungunya Virus Infection
《Open Journal of Rheumatology and Autoimmune Diseases》2021年第2期36-47,共12页Mariana do Socorro Quaresma Silva Rita Catarina Medeiros Sousa Cezar Augusto Muniz Caldas 
Background: Chikungunya fever is an infectious disease that can evolve to a subacute or chronic condition, with changes in the dail...
关键词：Chikungunya Fever Post-Infectious Inflammatory Disease ALPHAVIRUS 
Chikungunya infection:A potential re-emerging global threat被引量：5
《Asian Pacific Journal of Tropical Medicine》2016年第10期910-915,共6页Shanmugaraj Bala Murugan Ramalingam Sathishkumar 
The Department of Biotechnology,Bharathiar University,Coimbatore,Tamil Nadu,India for supporting this research through DST-FIST (SR/FST/LST-299/2006 Dt:31-01-2007);UGC-SAP (F.No.3-9/2007 (SAP-II) February 2007)
Infectious diseases are indeed a lifelong threat to everyone irrespective of age, sex, lifestyle and socio-economic status. The infectious diseases have persisted among the prominent causes of death globally. Recently...
关键词：AEDES MOSQUITOES ALPHAVIRUS Arthropod-borne disease CHIKUNGUNYA Non-Structural PROTEINS Structural PROTEINS 
鲑鱼甲病毒E1基因高保守区融合表达及免疫特性的分析
《淡水渔业》2016年第4期49-53,共5页蒋烨 杜航 唐丽杰 乔薪瑗 王丽 管雪婷 姜艳平 崔文 李一经 刘敏 
国家科技支撑计划(2013BAD12B02)
根据Gen Bank中公布的鲑鱼甲病毒(salmonid alphavirus,SAV)SAV 1、SAV 2和SAV3三个基因型中E1基因,选择高保守序列702 bp(436-1137)合成基因,命名为SAV E1,将其克隆到原核表达载体p Cold TF中构建重组质粒。然后将重组质粒转化到大肠...
关键词：鲑鱼甲病毒(salmonid alphavirus SAV) E1高保守蛋白 原核表达 免疫特性 
Architecture and biogenesis of plus-strand RNA virus replication factories被引量：6
《World Journal of Virology》2013年第2期32-48,共17页David Paul Ralf Bartenschlager 
Supported by The DFG,SFB638,TP A5 and SFB/TRR83,TP 13
Plus-strand RNA virus replication occurs in tight association with cytoplasmic host cell membranes. Both, viral and cellular factors cooperatively generate distinct organelle-like structures, designated viral replicat...
关键词：VIRAL REPLICATION factory VIRAL REPLICATION complex Plus-strand RNA VIRUS Membrane remodeling Virus-host interaction ALPHAVIRUS Enterovirus Coronavirus Flavivirus Hepatitis C VIRUS 
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