supported in part by the National Science Foundation of China(Grants 91642205 and 81830038);funds of Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing,China;funded by Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-004A).
Damage or microstructural alterations of the white matter can cause dysfunction of the intrinsic neural networks in a condition termed as white matter disease(WMD).Frequently detected on brain computed tomography and ...
supported by the National Natural Science Foundation of China(82371404,82271341,82071380,and 81873743);the Knowledge Innovation Program of Wuhan Shuguang Project(2022020801020454);the Tongji Hospital Foundation for Excellent Young Scientists(2020YQ06).
Neuromyelitis optica spectrum disorder(NMOSD)is an autoimmune inflammatory demyelinating disease of the central nervous system(CNS)accompanied by blood-brain barrier(BBB)disruption.Dysfunction in microglial lipid meta...
supported by the Deutsche Forschungsgemeinshaft (to CJ)。
Schwann cells,the myelinating glia of the peripheral nervous system,wrap axons multiple times to build their myelin sheath.Myelin is of paramount importance for axonal integrity and fast axon potential propagation.How...
Supported by Shenzhen Science and Technology Project,No. SGLH20180628161804465;The Clinical Research Project of The First Affiliated Hospital of Shenzhen University,No. 20203357035 and No. 20223357021。
BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) vaccinations have been administered worldwide, with occasional reports of associated neurological complications. Specifically, the impact of vacci...
In multiple sclerosis(MS),human endogenous retrovirus W family(HERV-W)envelope protein,pHERV-W ENV,limits remyelination and induces microglia-mediated neurodegeneration.To better understand its role,we examined the so...
National Key Research and Development Program(2018YFE0113900).
Purpose:To investigate the application of critical flicker fusion frequency(CFF)in demyelinating optic neuritis(DON).Methods:A cross-sectional study.A total of 127 eyes in 69 DON patients and 63 eyes in 33 healthy con...
the National Key Research and Development Program(2018YFE0113900).
Background:Magnetic resonance imaging(MRI)plays a significant role in assessing optic neuropathy and providing more detailed information about the lesion of the visual pathway to help differentiate optic neuritis from...
supported by the Natural Science Foundation of Zhejiang Province,China(LY17C090006,LQ16C090004,and LY18H090014)。
Dear Editor,Myelin,the lipid-rich insulation that supports the integrity of axons,enables rapid conduction of nerve impulses and information flow to distant brain areas[1].Oligodendrocytes(OLs)are glial cells that mye...
Neurofilaments are the major structural proteins of the neuronal cytoskeleton and are classified according to molecular weight into heavy,intermediate,and light chains.They are released into the interstitial fluid and...
BACKGROUND Lymphoplasmacytic lymphoma is a rare non-Hodgkin’s lymphoma,occurring mostly in the elderly.It develops slowly and leads to malignant proliferation of lymphoid line cells in the bone marrow,lymph nodes and...