DESMOPLASIA

作品数：6被引量：15H指数：3
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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors
《Acta Pharmaceutica Sinica B》2024年第7期3009-3026,共18页Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan Subhash C.Chauhan 
UTRGV School of medicine start up,CPRIT TREC Award RP230419 and Integrated Cancer Research Core(ICRC)-RP210180;Herb Kosten foundation for pancreatic cancer research;National Institutes of Health grants R01CA206069,SC1GM139727,SC2GM139715,R01CA210192 and R01CA204552.
The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological cargo.This study investigates u...
关键词：Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) DESMOPLASIA Extracellular vesicles EXOSOMES Tumor targeting Ormeloxifene Personalized medicine 
Tunable hybrid hydrogels with multicellular spheroids for modeling desmoplastic pancreatic cancer被引量：3
《Bioactive Materials》2023年第7期360-373,共14页Menekse Ermis Natashya Falcone Natan Roberto de Barros Marvin Mecwan Reihaneh Haghniaz Auveen Choroomi Mahsa Monirizad Yeji Lee Jihyeon Song Hyun-Jong Cho Yangzhi Zhu Heemin Kang Mehmet R.Dokmeci Ali Khademhosseini Junmin Lee Han-Jun Kim 
Dr.M.Ermis and Dr.N.Falcone contributed equally to this work.The authors gratefully acknowledge the funding by the National Institutes of Health(HL140951,HL137193,CA257558,DK130566);Dr.M.Ermis acknowledges The Scientific and Technological Research Council of Turkiye for 2219-International Postdoctoral Research Fellowship Program.
The tumor microenvironment consists of diverse,complex etiological factors.The matrix component of pancreatic ductal adenocarcinoma(PDAC)plays an important role not only in physical properties such as tissue rigidity ...
关键词：Pancreatic cancer DESMOPLASIA FIBROSIS Extracellular matrix Tumor microenvironment 
Pancreatic cancer: genetics, disease progression, therapeutic resistance and treatment strategies被引量：1
《Journal of Cancer Metastasis and Treatment》2021年第1期794-808,共15页Karnika Singh Gauri Shishodia Hari K.Koul 
supported in part by funds from Carroll W.Feist Endowed Chair in Cancer(Koul HK);LSUHSC-graduate stipend to Singh K.Koul HK is supported in part by the NIH/NCI RO1 R01CA242839.
Pancreatic cancer is a deadly disease and the third-highest cause of cancer-related deaths in the United States.It has a very low five-year survival rate(<5%)in the United States as well as in the world(about 9%).The ...
关键词：Pancreatic cancer signature mutations GEMCITABINE DESMOPLASIA therapeutic resistance IMMUNOTHERAPY 
Recent advances in immunotherapy for pancreatic cancer被引量：1
《Journal of Cancer Metastasis and Treatment》2020年第1期531-547,共17页Jeffrey Chi Rajvi Patel Hasan Rehman Shreya Goyal Muhammad Wasif Saif 
Pancreatic ductal adenocarcinoma(PDAC)remains a disease with a dismal prognosis.Since 1996 there have only been two upfront regimens found to be superior to gemcitabine:FOLFIRINOX(5-fluorouracil,leucovorin,irinotecan ...
关键词：Pancreatic ductal adenocarcinoma CHEMORESISTANCE DESMOPLASIA tumor microenvironment extracellular matrix IMMUNOGENICITY IMMUNOTHERAPY vaccines immune checkpoint inhibitors IMMUNOMODULATION 
Tumor reactive stroma in cholangiocarcinoma:The fuel behind cancer aggressiveness被引量：4
《World Journal of Hepatology》2017年第9期455-468,共14页Simone Brivio Massimiliano Cadamuro Mario Strazzabosco Luca Fabris 
Cholangiocarcinoma(CCA) is a highly aggressive epithelial malignancy still carrying a dismal prognosis, owing to early lymph node metastatic dissemination and striking resistance to conventional chemotherapy. Although...
关键词：Tumor microenvironment DESMOPLASIA Cancer-associated fibroblast Inflammation Tumor-associated macrophage Lymphatic endothelial cell Mesenchymal stem cell Extracellular matrix 
Targeting hyaluronan for the treatment of pancreatic ductal adenocarcinoma被引量：6
《Acta Pharmaceutica Sinica B》2016年第2期101-105,共5页Norihiro Sato Xiao-Bo Cheng Shiro Kohi Atsuhiro Koga Keiji Hirata 
supported in part by a grant-in-aid from the Ministry of Education, Culture, Sports, Science and Technologies of Japan (26462076)
Progression of cancer is often associated with interactions between cancer cells and extracellular matrix(ECM) surrounding them. Increasing evidence has suggested that accumulation of hyaluronan(HA), a major component...
关键词：Pancreatic DUCTAL ADENOCARCINOMA HYALURONAN TUMOR stroma DESMOPLASIA Tumor–stromal interaction Therapeutic target 4-Methylumbelliferone PEGPH20 
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