OXIDATIVESTRESS

作品数：22被引量：104H指数：7
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相关领域：医药卫生更多>>
相关作者：黄园吴玉杰胡小鹏金晨傅智轶更多>>
相关机构：北京体育大学皖南医学院弋矶山医院南方医科大学南方医院上海交通大学医学院附属第九人民医院更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Journal of Pharmacy and Pharmacology》《Journal of Intensive Medicine》更多>>
相关基金：国家自然科学基金安徽省自然科学基金重庆市自然科学基金更多>>
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Intestine-derived fibroblast growth factor 19 alleviates lipopolysaccharide-induced liver injury by regulating bile acid homeostasis and directly improving oxidative stress
《Journal of Intensive Medicine》2025年第1期79-88,共10页Xiaomeng Tang Jingjing Ning Yilin Zhao Shuyun Feng Lujing Shao Tiantian Liu Huje Miao Yucai Zhang Chunxia Wang 
supported by the National Natural Science Foundation of China(grant number:82171729);the Natural Science Foundation of Shanghai(grant number:23ZR1453000);the Shanghai Municipal Health Commission(grant number:202340076);the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant(grant number:20171928).
Background:Cholestasis plays a critical role in sepsis-associated liver injury(SALI).Intestine-derived fibroblast growth factor 19(FGF19)is a key regulator for bile acid homeostasis.However,the roles and underlying me...
关键词：FGF19 Bile acid OXIDATIVESTRESS Mitochondria dysfunction Acuteliver injury SEPSIS 
Injectable chitosan microspheres resisting inflammatory and oxidativestress for ameliorating intervertebral disc degeneration
《Science China Materials》2025年第2期610-625,共16页Lin Huang Wantao Wang Lei Liu Wenzheng Ma Jinghao Fan Dan Zhou Lei Zhao Zhaomin Zheng Hongmei Liu Decheng Wu 
supported by the Ministry of Science and Technology of China (2020YFA0908900);National Natural Science Foundation of China (21935011);Shenzhen Science and Technology Innovation Commission (KQTD20200820113012029, JCYJ20220530114409020, and 20231115134555001);Guangdong Provincial Key Laboratory of Advanced Biomaterials (2022B1212010003)。
The treatment of intervertebral disc (IVD) degeneration remains a significant challenge due to the uniqueischemic structure of the IVD, which comprises the scavengingof inflammatory cytokines, alleviation of cellular ...
关键词：chitosan microsphere nanozymes inflammatory relieving oxidative stress regulation intervertebral disc degeneration 
Synthesis, antibacterial evaluation, and safety assessment of Se@PLA as a potent bactericide against Xanthomonas oryzae pv. oryzae
《Chinese Chemical Letters》2024年第10期253-256,共4页Xingyu Chen Sihui Zhuang Weiyao Yan Zhengli Zeng Jianguo Feng Hongen Cao Lei Yu 
National Key Research and Development Program of China(No.2018YFD0200100);the fund of the joint-laboratory of Shanghai Dingya Pharmaceutical Chemical Technology Co.,Ltd.with Yangzhou University(2022–2027);the Yangzhou City and Yangzhou University Cooperation Program(No.YZ2023209);the Priority Academic Program Development of Jiangsu Higher Education Institutions for support。
A novel biodegradable material,Se@PLA,was designed and prepared via the selenization reaction of polylactic acid using NaHSe as the selenization reagent.This material shows excellent antibacterial activity(EC_(5)0=13...
关键词：Selenium Antibacterial activity OXIDATIVESTRESS Bacterium motility ENVIRONMENT-FRIENDLY 
Mitochondrial dysfunction: A promising therapeutic target for liver diseases
《Genes & Diseases》2024年第3期324-337,共14页Ping Chen Lichao Yao Mengqin Yuan Zheng Wang Qiuling Zhang Yingan Jiang Lanjuan Li 
funded by the Anti-aging Research Center of Wuhan University Education Development Foundation,Hubei,China(No.2002330);the National Stem Cell Clinical Research Project of China(China Medical Biotechnology Association 2019,No.007).
The liver is an important metabolic and detoxification organ and hence demands a large amount of energy,which is mainly produced by the mitochondria.Liver tissues of pa-tients with alcohol-related or non-alcohol-relat...
关键词：Chronic diseases Liverdamage Mesenchymalstem cell Mitochondrial dysfunction OXIDATIVESTRESS 
Hepatic DDAH1 mitigates hepatic steatosis and insulin resistance in obese mice: Involvement of reduced S100A11 expression被引量：1
《Acta Pharmaceutica Sinica B》2023年第8期3352-3364,共13页Xiyue Shen Kai Luo Juntao Yuan Junling Gao Bingqing Cui Zhuoran Yu Zhongbing Lu 
supported by grants from National Natural Science Foundation of China(82070250,32200631);Beijing Natural Science Foundation(5222029,China);China Postdoctoral Science Foundation(2022T150640);the Fundamental Research Funds for the Central Universities。
Dimethylarginine dimethylaminohydrolase 1(DDAH1)is an important regulator of plasma asymmetric dimethylarginine(ADMA)levels,which are associated with insulin resistance in patients with nonalcoholic fatty liver diseas...
关键词：ADMA DDAH1 Hepatic steatosis INSULINRESISTANCE S100A11 OXIDATIVESTRESS Inflammation Highfat diet 
Aconitum carmichaelii triggers neurotoxicity and Parkinson-like symptoms through initiation of ROS-mitochondrial apoptosis and the Nox5/DJ-1 signaling pathway
《BMEMat(BioMedical Engineering Materials)》2023年第2期153-167,共15页Meijun Pang Xin Song Yaodong Miao Yiwen Wang Chang Zhou Zihan Geng Jiayin Du Bernard Moussian Yanfang Su Xiuyun Liu Dong Ming 
National Key Research and Development Program,Grant/Award Number:2021YFF1200600;China Postdoctoral Science Foundation,Grant/Award。
Background:Aconitum carmichaelii,the mother root of Aconitum,has a long-applied history for treating many diseases in China.Increased use of it has prompted significant concerns regarding its extensive cardiotoxicity ...
关键词：Aconitum Carmichaelii apoptosis NEUROTOXICITY OXIDATIVESTRESS ZEBRAFISH 
Tibolone Reverses NAFLD in Ovariectomised Rats by Reducing Adiposity and Insulin Resistance
《Journal of Pharmacy and Pharmacology》2019年第4期148-164,共17页Lilian Brites Campos-Shimada Eduardo Hideo Gilglioni Danielle Aparecida Munhos Hermoso Ana Julia dos Reis Buzzo Rosangela Fernandes Garcia Elismari Rizato Martins-Maciel Emy Luiza Ishii-Iwamoto Clairce Luzia Salgueiro-Pagadigorria 
This study aimed to investigate the effects of tibolone,a synthetic steroid,on several metabolic dysfunctions induced by oestrogen deficiency,in rats.Ovariectomised(OVX)rats were used as animal model of postmenopausal...
关键词：TIBOLONE OVARIECTOMY hepatic STEATOSIS obesity OXIDATIVESTRESS 
Protective effects of a composition of Chinese herbs- Gurigumu-13 on retinal ganglion cell apoptosis in DBA/2J glaucoma mouse model被引量：3
《International Journal of Ophthalmology(English edition)》2018年第3期363-368,共6页Qiu-Li Zhang Wei Wang Yan Jiang Tian-Zi Zhang Zhan-Jun Lu Ao Jiang 
Supported by the National Natural Science Foundation of China(No.81660734)
AIM： To explore the concrete mechanism of a Mongolian compound medicine-Gurigumu-13 （GRGM） for glaucoma treatment. METHODS： DBA/2J mice, as glaucoma models, were intragastric administrated with GRGM to study the ...
关键词：GLAUCOMA retinal ganglion cells OXIDATIVESTRESS endoplasmic reticulum stress 
Fenugreek lactone attenuates palmitate-induced apoptosis and dysfunction in pancreatic β-cells被引量：2
《World Journal of Gastroenterology》2015年第48期13457-13465,共9页Jing Gong Hui Dong Shu-Jun Jiang Ding-Kun Wang Ke Fang De-Sen Yang Xin Zou Li-Jun Xu Kai-Fu Wang Fu-Er Lu 
Supported by The National Natural Science Foundation of China;No.81273683 and No.81473637
AIM: To investigate the effect of fenugreek lactone(FL) on palmitate(PA)-induced apoptosis and dysfunction in insulin secretion in pancreatic NIT-1 β-cells. METHODS: Cells were cultured in the presence or absence of ...
关键词：FENUGREEK LACTONE Diabetes OXIDATIVESTRESS Insulin SECRETION Apoptosis 
Acupuncture mechanism on oxidative stress in various diseases
《Science Foundation in China》2015年第2期60-65,共6页LIN LiTing LI Hui YANG JingWen ZENG XiangHong HE Tian SHI GuangXia LIU CunZhi 
supported by the National Natural Science Foundation of China(Grant Nos.30801483, 81222050,81303122);the Beijing Nova Program (Grant No.2014B063)
There is compelling evidence to substantiate the notion that oxidative stress,in which the production of reactive oxygen species(ROS)overwhelms antioxidant defense,is a common feature of many acute and chronic disorde...
关键词：ACUPUNCTURE Mechanism OXIDATIVESTRESS Reactiveoxygenspecies Redoxfactors doi:１０．１６２６２/j．cnki．１００５Ｇ０８４１．２０１５．０２．００１ 
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