ANTITUBERCULOSIS

作品数：20被引量：37H指数：3
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相关领域：医药卫生更多>>
相关作者：孟庆义李锡芳更多>>
相关机构：钦州市第一人民医院中国药科大学更多>>
相关期刊：《中华医学写作杂志》《World Journal of Clinical Cases》《Infectious Microbes & Diseases》《Food Science and Human Wellness》更多>>
相关基金：国家自然科学基金更多>>
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Understanding antituberculosis drug-induced hepatotoxicity:Risk factors and effective management strategies in the pediatric population
《World Journal of Clinical Pediatrics》2025年第2期47-55,共9页Pooja Semwal Manjit Kaur Saini Moinak Sen Sarma 
Antituberculosis drug-induced hepatotoxicity(ATDIH)is a significant concern while managing pediatric tuberculosis.There is limited data on pediatric ATDIH,and much of the management practices are extrapolated from adu...
关键词：Antituberculosis therapy DRUG Liver INJURY Isonaizid RIFAMPICIN PYRAZINAMIDE 
Breaking barriers:The potential of nanosystems in antituberculosis therapy
《Bioactive Materials》2024年第9期106-134,共29页Christian S.Carnero Canales Jessica Ingrid Marquez Cazorla Renzo Marianito Marquez Cazorla Cesar Augusto Roque-Borda Giulia Polinario Rufo A.Figueroa Banda Rafael Miguel Sabio Marlus Chorilli Helder A.Santos Fernando Rogerio Pavan 
support from the S˜ao Paulo Research Foundation(FAPESP,Brazil),Grant numbers#01664-1,#2022/02661-3 and#2020/16573-3,respectively;National Council for Scientific and Technological Development(CNPq):Productivity Research Fellows(PQ CNPq):305408/2022-4;This study is part of the National Institute of Science and Technology in Pharmaceutical Nanotechnology:a transdisciplinary approach,INCT-NANOFARMA,which is supported by S˜ao Paulo Research Foundation(FAPESP,Brazil)Grant#2014/50928-2,and by“Conselho Nacional de Desenvolvimento Científico e Tecnol′ogico”(CNPq,Brazil)Grant#465687/2014-8.Prof.H.A.Santos acknowledges financial support from the Research Council of Finland(Grant No.331151)and the UMCG Research Funds.
Tuberculosis(TB),caused by Mycobacterium tuberculosis,continues to pose a significant threat to global health.The resilience of TB is amplified by a myriad of physical,biological,and biopharmaceutical barriers that ch...
关键词：TUBERCULOSIS Mycobacterium tuberculosis Nanoscale drug delivery systems Barriers Drug resistance 
Insight of Natural Compounds Halimane Diterpenoids against Mycobacterium tuberculosis: Virtual Screening, DFT, Drug-Likeness, and Molecular Dynamics Approach
《Computational Molecular Bioscience》2024年第2期35-58,共24页Laurent Gael Eyia Andiga Boris Davy Bekono Désiré Mama Bikele Pie Pascal Onguéné Amoa Luc Calvin Owono Owono Luc Léonard Mbaze Meva’a 
In the purpose to design novel antituberculosis (anti-TB) drugs agents against Mycobacterium tuberculosis (Mtb), we have built a molecular library around 42 Halimane Diterpenoids isolated from natural sources. Two Mtb...
关键词：Antituberculosis Druglikeness Density Functional Theory Halimane Diterpenoids Molecular Docking Molecular Dynamics Simulation 
A narrative review on inhibitory effects of edible mushrooms against malaria and tuberculosis-the world’s deadliest diseases
《Food Science and Human Wellness》2023年第4期942-958,共17页Ashaimaa Y.Moussa Baojun Xu 
supported by two grants(UIC202007 and UIC202107)from BNU-HKBU United International College.
The isolated secondary metabolites from 39 edible mushrooms are reported,among which 107 compounds were active,61 demonstrated antitubercular activities with IC_(50) range of 0.2-50μg/mL and 46 manifested antimalaria...
关键词：ANTITUBERCULOSIS ANTIPLASMODIAL MACROFUNGI MUSHROOMS Structure activity relationship 
A Systematic Review on Antituberculosis Drug Discovery and Antimycobacterial Potential of Biologically Synthesized Silver Nanoparticles:Overview and Future Perspectives
《Infectious Microbes & Diseases》2022年第4期139-148,共10页Christian K.Ezeh Chibuzor N.Eze Uju M.E.Dibua Stephen C.Emencheta 
Rapid emergence and quick evolution of drug-resistant and aggressive mycobacterial strains have resulted in the present antimycobacterial drug crisis and the persistence of tuberculosis as a major public health proble...
关键词：antimycobacterial activity silver nanoparticles CYTOTOXICITY biological synthesis TUBERCULOSIS MYCOBACTERIAL 
Delayed diagnosis and comprehensive treatment of cutaneous tuberculosis:A case report被引量：2
《World Journal of Clinical Cases》2021年第16期4007-4015,共9页Lu-Jue Gao Zi-Hui Huang Quan-Yong Jin Guo-Ying Zhang Min-Xing Gao Jia-Yan Qian Si-Xun Zhu Yang Yu 
The Key Science and Technology Project of Nanjing Health and Family Planning Commission,No.ZKX18042;The Youth Talent Project of Nanjing Health and Fitness Commission,No.QRX17030;and The Key Science and Technology Project of National Health Commission,No.ZKX18048.
BACKGROUND Tuberculosis(TB)is a widespread infectious disease,with an incidence that is increasing worldwide.Cutaneous TB(CTB)occurs rarely,accounting for less than 1%of all TB cases.Due to the clinical presentation a...
关键词：Cutaneous tuberculosis Delayed diagnosis Dressing change ANTITUBERCULOSIS Case report 
New antituberculosis drugs targeting the respiratory chain
《Chinese Chemical Letters》2020年第6期1357-1365,F0003,共10页Qian Li Xiaoyun Lu 
financial support from the National Natural Science Foundation of China(No.81922062);Guangdong Provincial Science and Technology Program(No.2018A050506043)and Jinan University。
With the emergence of multidrug-resistant tuberculosis and extensive drug-resistant tuberculosis strains,there is an urgent need to develop novel drugs for the treatment of tuberculosis.The respiratory chain is a prom...
关键词：Respiratory chain Antituberculosis drug QcrB NADH-2 ATP synthase 
NAT2 Involed in the Susceptibility to Antituberculosis Drug-Induced Liver Injury
《Journal of Advances in Medicine Science》2019年第3期6-11,共6页Donglin Zhu Changzhi Xu Zhizhi Xie Gang Xiao Yun Xi 
Objective: To investigate whether the N-acetyltransferase 2 (NAT2) gene is involved in the development of susceptibility to antituberculosis drug-induced liver damage (ATDLI) in patients with pulmonary tuberculosis in...
关键词：NAT2 MassARRAY TUBERCULOSIS Liver INJURY Genetic POLYMORPHISM 
Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury被引量：1
《Asian Pacific Journal of Tropical Medicine》2018年第11期609-620,共12页Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala Monika Bhadauria 
financially supported by UGC Major Research Project [(F42-520/2013(SR)]
To evaluate hepatic injury induced by antituberculosis drugs(ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis(bee hive product) against ATDs induced hepatic injury. Meth...
关键词：ANTITUBERCULOSIS drugs PROPOLIS Biochemical Hepatic injury 
Association of Genetic Polymorphism of GSTM1 and GSTT1 with the Susceptibility to Antituberculosis Drug-induced Hepatotoxicity in Chinese Population
《Journal of Advances in Medicine Science》2018年第3期80-83,共4页Gang Xiao 
Objective To investigate the relationship between the polymorphism of glutathione S transferase M1, T1(GSTM1, GSTT1) gene and the susceptibility to antituberculosis drug induced hepatotoxicity (ATDH) in patients with ...
关键词：GSTM1 GSTT1 TUBERCULOSIS HEPATOTOXICITY Genetic Polymorphism 
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