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ANTITUMOR: 作品数：470被引量：1206H指数：15; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：明艳林陈良华刘韶松齐宪荣李润涛更多>>; 相关机构：北京大学天津医科大学中国药科大学福建省亚热带植物研究所更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>

Therapeutic potential of kakkatin derivatives against hepatocellular carcinoma: 《World Journal of Clinical Oncology》2025年第3期13-19,共7页Sahiba Chahal Vikram Patial; Supported by the Indian Council of Scientific and Industrial Research,No.MLP0204(CSIR-IHBT no.5712).; In this article,we commented on the work done by Jiang et al,where they syn-thesized a kakkatin derivative,6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-me-thoxy-4H-chromen-4-one(HK),and investigated its antitumor activ...; 关键词：Hepatocellular carcinoma ANTITUMOR Kakkatin PROTOONCOGENES CISPLATIN

Computation of Structure Activity and Design of Chalcone Derivatives: 《Computational Chemistry》2019年第2期51-58,共8页Yan Jiang Qi Yang Shuping Zhang; Based on the antitumor activity of chalcone derivatives and their structure, the structure-activity relationship of chalcone derivatives was analyzed by CoMFA (comparative molecular field analysis) method and then the...; 关键词：Three Dimensional-Quantitative Structures ACTIVITY Relationship CHALCONE DERIVATIVES COMPARATIVE Molecular Field Analysis ANTITUMOR ACTIVITY

Antitumor Research on Artemisinin and Its Bioactive Derivatives被引量：8: 《Natural Products and Bioprospecting》2018年第4期303-319,共17页Yunqin Zhang Guowei Xu Shuqun Zhang Dong Wang PSaravana Prabha Zhili Zuo; supported by CAS"Light of West China"Program([2014]91 to Z.Z.);the Basic Research Plan of Yunnan Provincial Science and Technology Department(grant number 2014FA042);CAS Strategic biological resources service network(ZSTH-021);the Strategic Priority Research Program of the Chinese Academy of Sciences,Grant No.XDA12030206.; Cancer is the leading cause of human death which seriously threatens human life.The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties.Simultaneously,a varie...; 关键词：ARTEMISININ Artemisinin derivatives ANTITUMOR ACTIVITY MECHANISM

Synthesis, Antitumor Activity and Preliminary Structure-activity Relationship of 2-Aminothiazole Derivatives被引量：3: 《Chemical Research in Chinese Universities》2016年第6期929-937,共9页LI Hongshuang WANG Xinran DUAN Guiyun XIA Chengcai XIAO Yuliang LI Furong GE Yanqing YOU Guirong HAN Junfen FU Xiaopan; In this paper, we described the synthesis of 2-aminoflfiazole sublibrary containing methyl, bromo, phenylor butylidene at 4- or/and 5-position of its core. All target compounds were evaluated tbr their antitumor activ...; 关键词：2-Aminotlfiazole ANTITUMOR activity STRUCTURE-ACTIVITY RELATIONSHIP

Synthesis and screening of novel inositol phosphonate derivatives for anticancer functions in vitro被引量：1: 《Chinese Chemical Letters》2015年第3期329-333,共5页Wen-Bin Chen Jian-Bing Liu Dao-Lei Dou Fan-Bo Song Lu-Yuan Li Zhen Xi; financially supported by Tianjin Municipal Natural Science Foundation (Key Program No.12JCZDJC22000);Ministry of Science and Technology of China (Nos.2010CB126102,2011BAE06B05); Phosphonates have been frequently used as suitable isosteric and isoelectronic replacements for biologically important phosphates in the development of drugs or drug candidates because of their stability toward the ac...; 关键词：phosphonate inositol toward anticancer screening instead biologically antitumor dissolved hydroxyl

The Reaction of Cyanoacetylhydrazine with Chloroacetone: Synthesis of 1,2,4-Triazine, 1,3,4-Oxadiazine and Their Fused Derivatives with Antitumor Activities: 《Open Journal of Medicinal Chemistry》2012年第1期1-9,共9页Rafat M. Mohareb Eman M. Samir; The reaction of cyanoacetylhydrazine with chloroacetone gave the N-(1-chloropropan-2-ylidene)-2-cyanoacetohy- drazide. This compound reacted with either hydrazine hydrate or phenylhydrazine to give the corresponding 1...; 关键词：1 2 4-Triazine 3 4-Oxadiazine PYRAZOLE ANTITUMOR

Design,synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino)quinoline-3-carbonitrile derivatives被引量：1: 《Chinese Chemical Letters》2010年第5期554-557,共4页Bao Liu,Qi Dong You,Zhi Yu Li Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China; supported by National Natural Science Foundation of China(No.30371676); A series of new 6,7-disubstituted-4-(benzothiazol-6-ylamino)quinoline-3-carbonitrile derivatives(12a-l) were synthesized.The cytotoxicity of 12 new compounds was evaluated in AGS,HepG2 and HT-29 cell lines.The results...; 关键词：3-Quinolinecarbonitrile derivatives SYNTHESIS ANTITUMOR

Design,synthesis and antitumor activity of 3-substituted quinolone derivatives (Ⅰ)被引量：1: 《Chinese Chemical Letters》2008年第12期1395-1397,共3页Hua Wang Qi Dong You Zhi Yu Li Yi Quan Zou; supported by National Natural Science Foundation of China (No.30271543).; A series of quinolone derivatives containing benzimidazole, benzoxazole or benzothiazole ring were synthesized. The cytotoxicity of 12 new compounds was evaluated in KB, Be17402, A2780 and HT-29 cell lines. Most of sy...; 关键词：Quinolone derivatives SYNTHESIS ANTITUMOR

Synthesis and antitumor activity of N^1-acetylamino-(5-alkyl/aryl-1,3,4-thiadiazole-2-yl)-5-fluorouracil derivatives被引量：4: 《Chinese Chemical Letters》2008年第11期1281-1284,共4页Kai Bo Zheng Jun He Jie Zhang; A new series of N^1-acetylamino-（5-alkyl/aryl- 1,3,4-thiadiazole-2-yl）-5-fluorouracil derivatives were designed and synthesized. These compounds have not been reported in literature, and their structure chemical wer...; 关键词：5-Fluorouracil derivatives 1 3 4-THIADIAZOLE SYNTHESIS ANTITUMOR

Synthesis and antitumor activity of derivatives of 23-hydroxybetulinic acid: 《Chinese Chemical Letters》2007年第10期1195-1198,共4页Jin Pei Zhou Dan Li Xiao Ming Wu Wen Cai Ye Lu Yong Zhang; supported by the National Natural Science Foundation of the People's Republic of China(No.30472083).; A series of natural product 23-hydroxybetulinic acid derivatives were prepared. In the preparation of mono-O-benzoyl ester derivative, it was observed that benzoyl group migrated from 3-0- to 23-O-position during the ...; 关键词：23-Hydroxybetulinic acid TRITERPENOID ANTITUMOR SYNTHESIS

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