POLYMORPHISMS

作品数：634被引量：2320H指数：17
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Evaluating the scope of human leukocyte antigen polymorphisms influencing hepatitis B virus-related liver cancer and cirrhosis through multi-clustering analysis
《World Journal of Gastroenterology》2025年第7期156-159,共4页Shi Li Yue Xi Xue-Ying Dong Wen-Bin Yuan Jing-Feng Tang Ce-Fan Zhou 
Supported by National Natural Science Foundation of China,No.32270768,No.82273970,No.32070726,and No.82370715;National Key R&D Program of China,No.2023YFC2507904;the Innovation Group Project of Hubei Province,No.2023AFA026.
Hepatitis B virus remains a major cause of cirrhosis and hepatocellular carcinoma,with genetic polymorphisms and mutations influencing immune responses and disease progression.Nguyen et al present novel findings on sp...
关键词：Hepatitis B virus Gene polymorphisms Multi-clustering analysis Genetic markers Personalized medicine Clinical implications 
Association of vitamin D and polymorphisms of its receptor with antiviral therapy in pregnant women with hepatitis B被引量：2
《World Journal of Gastroenterology》2023年第19期3003-3012,共10页Rui Wang Xia Zhu Xuan Zhang Huan Liu Yu-Lin Ji Yong-Hua Chen 
Supported by the Key Research and Development Projects in Sichuan Province,No.2021YFS0168;the National Scientific and Technological Major Project for Infectious Diseases Control in China,No.2018ZX10715-003.
BACKGROUND The interruption of mother-to-child transmission(MTCT)is considered important to decrease the individual and population morbidity of hepatitis B virus(HBV)infection as well as the global burden of hepatitis...
关键词：Hepatitis B virus Vitamin D Vitamin D receptor polymorphism Antiviral therapy PREGNANCY Mother-to-child transmission 
Locked nucleic acid real-time polymerase chain reaction method identifying two polymorphisms of hepatitis B virus genotype C2 infections,rt269L and rt269I
《World Journal of Gastroenterology》2023年第11期1721-1734,共14页Kijeong Kim Yu-Min Choi Dong Hyun Kim Junghwa Jang Won Hyeok Choe Bum-Joon Kim 
Supported by the National Research Foundation of Korea,No.2022R1A2B5B01001421;the Korea Health Technology R&D Project through the Korea Health Industry Development Institute,the Ministry of Health&Welfare,Republic of Korea,No.HI22C0476.
BACKGROUND The presence of two distinct hepatitis B virus(HBV)Pol RT polymorphisms,rt269L and rt269I,could contribute to the unique clinical or virological phenotype of HBV genotype C2.Therefore,a simple and sensitive...
关键词：Hepatitis B virus Genotype C2 POLYMERASE rt269 Locked nucleic acid-real time-polymerase chain reaction Chronic hepatitis B 
Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study被引量：3
《World Journal of Gastroenterology》2022年第21期2334-2349,共16页Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler 
results in part from collaboration and network activities promoted under the frame of the international network GENIEUR (Genes in Irritable Bowel Syndrome Research Network Europe),which has been funded by the COST program (BM1106, www.GENIEUR.eu);currently supported by the European Society of Neurogastroenterology and Motility (ESNM, www.ESNM.eu)
BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bo...
关键词：Irritable bowel syndrome 5-HT3 receptor subunit gene polymorphisms Single-nucleotide polymorphism score Depression ANXIETY SOMATIZATION 
MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in Taiwan被引量：2
《World Journal of Gastroenterology》2021年第34期5737-5752,共16页Chia-Cheng Lee Yu-Cheng Kuo Je-Ming Hu Pi-Kai Chang Chien-An Sun Tsan Yang Chuan-Wang Li Chao-Yang Chen Fu-Huang Lin Chih-Hsiung Hsu Yu-Ching Chou 
the grant from the Ministry of National Defense-Medical Affairs Bureau,Taiwan,No.MND-MAB-110-109 and No.MND-MAB-D-111059.
BACKGROUND Identifying novel colorectal cancer(CRC)prognostic biomarkers is crucial to helping clinicians make appropriate therapy decisions.Melatonin plays a major role in managing the circadian rhythm and exerts onc...
关键词：Colorectal cancer MELATONIN HYPERMETHYLATION Polymorphism Prognosis Biomarker 
Association of XPG rs2094258 polymorphism with gastric cancer prognosis被引量：5
《World Journal of Gastroenterology》2019年第34期5152-5161,共10页Xiao-Qin Wang Paul D Terry Yang Li Yue Zhang Wen-Jing Kou Ming-Xu Wang 
Supported by the Fundamental Research Funds for the Central Universities,No.zdyf2017007
BACKGROUND The xeroderma pigmentosum group G(XPG)gene at chromosome 13q33 consists of 15 exons,which may be related to the occurrence and development of gastric cancer(GC).AIM To examine the association of several com...
关键词：Xeroderma pigmentosum group G Single NUCLEOTIDE POLYMORPHISMS rs2094258 GASTRIC cancer PROGNOSIS 
Role of NLRP3 inflammasome in inflammatory bowel diseases被引量：38
《World Journal of Gastroenterology》2019年第33期4796-4804,共9页Evanthia Tourkochristou Ioanna Aggeletopoulou Christos Konstantakis Christos Triantos 
Inflammasomes are multiprotein intracellular complexes which are responsible for the activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 has been a subject of intensive investigation. ...
关键词：NLRP3 INFLAMMASOME Inflammatory BOWEL diseases MUCOSAL immune system INTERLEUKIN 1β INTERLEUKIN 18 NLRP3 gene POLYMORPHISMS 
Lethal-7-related polymorphisms are associated with susceptibility to and prognosis of gastric cancer被引量：3
《World Journal of Gastroenterology》2019年第8期1012-1023,共12页Zhi-Fang Jia Dong-Hui Cao Yan-Hua Wu Mei-Shan Jin Yu-Chen Pan Xue-Yuan Cao Jing Jiang 
Supported by National Natural Science Foundation of China,No.81703293,81673145,and No.81373084;the Research Program of the Education Department of Jilin Province,No.2016487;the Scientific and Technological Development Program of Jilin Province,No.20180414055GH
BACKGROUND The lethal-7(let-7)family members and their targets are involved in the development and progression of tumors.Let-7-related polymorphisms have been reported to be associated with tumorigenesis and prognosis...
关键词：GASTRIC cancer Risk SUSCEPTIBILITY PROGNOSIS POLYMORPHISM Lethal-7 LIN28A IL23R 
Promoting genetics in non-alcoholic fatty liver disease: Combined risk score through polymorphisms and clinical variables被引量：3
《World Journal of Gastroenterology》2018年第43期4835-4845,共11页Umberto Vespasiani-Gentilucci Paolo Gallo Chiara Dell' Unto Mara Volpentesta Raffaele Antonelli-Incalzi Antonio Picardi 
Non-alcoholic fatty liver disease(NAFLD) has a prevalence of approximately 30% in western countries, and is emerging as the first cause of liver cirrhosis and hepatocellular carcinoma(HCC). Therefore, risk stratificat...
关键词：Non-alcoholic fatty liver disease Single nucleotide polymorphism Patatin-like phospholipase domain-containing protein 3 Transmembrane 6 superfamily member 2 Membrane bound O-acyltransferasedomain containing 7 Glucokinase regulatory gene Risk score Non-alcoholic steatohepatitis Non-alcoholic steatohepatitis cirrhosis Hepatocellular carcinoma 
Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?被引量：16
《World Journal of Gastroenterology》2018年第36期4152-4163,共12页Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini 
Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesi...
关键词：Biomarker ANGIOPOIETIN Neutrophil-tolymphocyte ratio POLYMORPHISMS SORAFENIB MicroRNA ADVERSE events Hepatocellular carcinoma Vascular ENDOTHELIAL growth factor 
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