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the National Natural Science Foundation of China:a Study on the Use of Tongfengqingxiao for Treating Gouty Arthritis and Neutrophil Extracellular Traps Formation based on the Transforming Growth Factor-β1 Signaling Pathway (No. 81860857);a Study on the Mechanism by which Tongfeng Qingxiao Regulates the Toll-like receptors-myeloid Differentiation Factor 88-nuclear Factor Kappa-B Signaling Pathway in Gouty Arthritis Rats with Gut Dysbiosis and Dampness-Heat Syndrome based on the Gut-enteric-microbiota Axis (No. 82060871);National Natural Science Foundation of Jiangxi Province:a Study on the Regulatory Mechanism of the Toll-like receptors-Myeloid differentiation factor 88-nuclear factor kappa-B Signaling Pathway Related to Dysbacteriosis of the Intestinal Flora with Gouty Arthritis in Rats Mediated by Tongfengqingxiao,based on the “Gut-Microbiota” Axis (No. 20202BAB206071)。
OBJECTIVE: To evaluate the indicators of an animal model of gouty arthritis(GA) with dampness heat accumulation and the intervention effect of Tongfeng Qingxiao formula(痛风清消方, TFQXF). METHODS: Seventy-two healthy...
supported by grants from the National Natural Science Foundation of China(No.32270947);Yunnan Applied Basic Research Projects,Kunming Medical University Union Special Fund(No.202301AY070001-043,No.202301AY070001-159);The Ten Thousand Scientists Program of Yunnan Province(No.YN-WR-MY-2018-040,No.YNWR-QNBJ-2018-152);535 Talent Project of First Affiliated Hospital of Kunming Medical University(No.2022535Q01);Yunnan Clinical Center for Skin Immune Diseases(No.ZX2019-03-02).
A 32-year-old male patient with gout presented to First Affiliated Hospital of Kunming Medical University for the first time,complaining of intermittent knee and ankle pain for the past 4 years.The highest level of hi...
To the Editor:Gouty arthritis,an autoinflammatory disease,exhibits a rapid onset of clinical symptoms but often resolve spontaneously within 7–10 days.In the acute gouty inflammatory responses,monosodium urate(MSU)cr...
A 50-year-old male patient with a history of chronic tophaceous gout presented with low back pain and bilateral shoulder,hip,knee,and buttock pain for 1 year.He had nocturnal exacerbations of buttock pain and signific...
BACKGROUND Gout is a disease characterized by hyperuricemia,and resultant deposition of uric acid crystals in tissues.While typically manifested as intraarticular crystals or tophi,gout can also cause pathology at ent...
BACKGROUND Gout is a common type of inflammatory arthritis caused by the deposition of monosodium urate crystals in the joints and surrounding tissues.It typically appears with abrupt and intense pain,redness,and swel...
Supported by the National Natural Science Foundation of China,No.81774336(to Pang ZH).
BACKGROUND Gouty tophi are a chronic granulomatous caused by a deposition of monosodium urate crystal deposition in the body.Once broken,it may easily induce severe infection.Sepsis complicated with secondary hemophag...
BACKGROUND Gouty tophus is rarely reported in the head and neck areas.To the best of our knowledge,this is the first report on multiple gouty tophi in the head and neck with normal serum uric acid(SUA)levels.CASE SUMM...
Supported by the National Natural Science Foundation of China:Research on the Mechanism of Chinese Herbal Compound Up-regulating Salivary Gland AQP5 and Increasing Intracellular Ca2+in Salivary Gland Cells based on the Theory of"Homology of Jin and Blood"(No.81273714);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Priority Nursing Discipline Project of Jiangsu Province:Study on the Mechanism of Fire Needle Regulating Acute Gouty Arthritis NLRP3 Inflammasome Activation(No.2019YSHL001)。
OBJECTIVE:To explore the therapeutic effect and inflammatory mechanism of fire needles on gouty arthritis.METHODS:Sixty male Sprague-Dawley rats were divided into four groups,that is,control group,the model group,the ...
Gout is a metabolic disorder that is characterized by a deposition of monosodium urate crystals in the joint or soft tissue. Gout manifestations in head and neck region are rare, and larynx is an infrequently affected...