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NUCLEOSOMES: 作品数：17被引量：28H指数：2; 导出分析报告; 相关领域：生物学更多>>; 相关作者：孙啸刘宏德周传政任松叶蔡禄更多>>; 相关机构：东南大学内蒙古科技大学中国科学院南开大学更多>>; 相关期刊：《Science China(Life Sciences)》《Frontiers in Biology》《Science China Chemistry》《Journal of Cancer Metastasis and Treatment》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划更多>>

The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications被引量：1: 《Protein & Cell》2023年第3期165-179,共15页Yanjing Li Kexue Gei Tingting Li Run Cai Yong Chen; supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37010303 to Y.C.);the National Natural Science Foundation of China(31670748,31970576 to Y.C.,and 32071195 and 31900934 to Y.L.);the Young Elite Scientist Sponsorship Program by Chinese Association for Science and Technology(YESS20170198 to Y.L.);the National Postdoctoral Program for Innovative Talents(Bx201700263 to Y.L.).; Histone lysine methyltransferases(HKMTs)deposit methyl groups onto lysine residues on histones and play important roles in regulating chromatin structure and gene expression.The structures and functions of HKMTs have ...; 关键词：NUCLEOSOME cryo-EM structures histone methyltransferases epigenetics histone methylation TUMORIGENESIS

AtMCM10 promotes DNA replication-coupled nucleosome assembly in Arabidopsis被引量：1: 《Journal of Integrative Plant Biology》2023年第1期203-222,共20页Xinjie Zhao Jingyi Wang Dan Jin Jinkui Cheng Hui Chen Zhen Li Yu Wang Huiqiang Lou Jian-Kang Zhu Xuan Du Zhizhong Gong; supported by National Natural Science Foundation of China (31921001)。; Minichromosome Maintenance protein 10(MCM10)is essential for DNA replication initiation and DNA elongation in yeasts and animals.Although the functions of MCM10 in DNA replication and repair have been well documented,...; 关键词：AtMCM10 H3K27me1 nucleosomes assembly

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) contributes to incorporation of histone variant H2A.Z into nucleosomes: 《Protein & Cell》2019年第9期694-699,共6页Ling-Yao Wang Yun-xiao He Min Li Jian Ding Yi Sui Joan W.Conaway Ronald C.Conaway Yong Cai Jingji Jin; Current research has dem on strated that the dynamic distribution of histone variant H2A.Z at specific loci can be regulated by ATP-dependent chromatin remodelers, histone chaperones and histone post-translational mod...; 关键词：HISTONE CHROMATIN CHAPERONES

Nuclear actin switch of the IN080 remodeler: 《Journal of Molecular Cell Biology》2019年第5期343-344,共2页Jun Wu Yimin Lao Bing Li; the National Key R&D Program of China(2018YFC1004500);the National Natural Science Foundation of China(31872817 to B.L).; Eukaryotic DNA is wrapped in nucleosomes, which impede the access of transcription factors and regulatory proteins to template DNA. Chromatin remodelers utilize the energy from ATP hydrolysis to drive histone movement...; 关键词：EUKARYOTIC DNA NUCLEOSOMES of the FIELD

DNA damage in nucleosomes: 《Science China Chemistry》2019年第5期561-570,共10页Mengtian Ren Jing Bai Zhen Xi Chuanzheng Zhou; supported by the National Natural Science Foundation of China(21572109,21877064,21740002);the National Key R&D Program of China(2017YFD0200501); Eukaryotic genomic DNA is packed into chromatin, whose fundamental structural unit is the nucleosome. As DNA-histone protein complexes, nucleosomes show different properties toward exogenous and endogenous DNA-damagin...; 关键词：DNA damage DNA ALKYLATION DNA-protein CROSS-LINK NUCLEOSOME radical reactive intermediate

Chemically synthesized histone H2A Lys13 di-ubiquitination promotes binding of 53BP1 to nucleosomes被引量：2: 《Cell Research》2018年第2期257-260,共4页Jia-Bin Li Yun-Kun Qi Qiao-Qiao He Hua-Song Ai San-ling Liu Jia-Xing Wang Ji-Shen Zheng Lei Liu Changlin Tian; Acknowledgments We thank Drs Rui-Ming Xu and Qing-Long You （Institute of Biophysics, Chinese Academy of Sciences） for kindly providing the GST-53BP1 plasmid. We also thank the Center for Biomedical Analysis of Tsinghua University for sample analysis. This work was supported by the National Key Research and Development Plan （2017YFA0505200 and 2016YFA0400903） and the National Natu- ral Science Foundation of China （21532004, 81621002, 21621003 and 21708036）.; Dear Editor, p53-binding protein 1 （53BP1） is a critical regulator of cellular response to DNA double-strand breaks （DSBs） . To accomplish its repair function, 53BP1 must be recruited to the chromatin surrounding...; 关键词：H2A 化学绑定 p53 蛋白质约束力 DNA 管理者

Transcriptional Regulation of the Ambient Temperature Response by H2A.Z Nucleosomes and HSF1 Transcription Factors in Arabidopsis被引量：17: 《Molecular Plant》2017年第10期1258-1273,共16页Sandra Cortijo Varodom Charoensawan Anna Brestovitsky Ruth Buning Charles Ravarani Daniela Rhodes John van Noort Katja E. Jaeger Philip A. Wigge; Temperature influences the distribution, range, and phenology of plants. The key transcriptional activators of heat shock response in eukaryotes, the heat shock factors （HSFs）, have undergone large-scale gene amplif...; 关键词：gene expression regulation plant temperature sensing and signaling TRANSCRIPTOMICS nucleosome dynamics histone variant H2A.Z heat shock transcription factors

Nucleosomes Suppress Spontaneous Mutations Base-Specifically in Eukaryotes: 《Science Foundation in China》2012年第1期23-23,共1页; A research team led by Professor He Xionglei at the College of Life Sciences,Sun Yat-sen(Zhongshan) University made a breakthrough in understanding how chromatin structure regulates spontaneous mutations,with a discov...; 关键词：真核细胞核小体突变基础生命科学学院中山大学结构调整结构单元

Histone variants:making structurally and functionally divergent nucleosomes and linkers in chromatin: 《Frontiers in Biology》2011年第2期93-101,共9页Leilei SHI Yuda FANG; supported by the National Natural Science Foundation of China(Grant No.91019006 to Y.F.);the Chinese Academy of Sciences(No.KSCX2-YW-N-099 to Y.F.)。; In addition to the post-translational modifications of histone proteins,emerging literature suggests that the mosaic nucleosomes formed by incorporation of various histone variants provide another mechanism for modify...; 关键词：H2AX H2AZ H3.3 CenH3 H1

Multifunctionality of the linker histones： an emerging role for protein-protein interactions被引量：2: 《Cell Research》2010年第5期519-528,共10页Steven J McBryant Xu Lu Jeffrey C Hansen; Linker histones, e.g., H1, are best known for their ability to bind to nucleosomes and stabilize both nucleosome structure and condensed higher-order chromatin structures. However, over the years many investigators ha...; 关键词：CHROMATIN linker histone higher-order structure NUCLEOSOMES

NUCLEOSOMES