FIBROGENESIS

作品数：46被引量：605H指数：15
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相关领域：医药卫生更多>>
相关作者：陈志南边惠洁李浩吴佼更多>>
相关机构：第四军医大学同济大学上海中医药大学更多>>
相关期刊：《Journal of Bio-X Research》《World Journal of Gastroenterology》《肝脏》《Current Medical Science》更多>>
相关基金：国家自然科学基金河北省自然科学基金上海市教育委员会重点学科基金广西壮族自治区自然科学基金更多>>
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TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway
《Current Medical Science》2024年第3期519-528,共10页Jia SONG Dong-lei SUN Chen-yang LI Yu-xin LUO Qian LIU Yue YAO Hong ZHANG Ting-ting YANG Mei SONG Xin-li BAI Xiao-lan ZHANG 
supported by grants from the National Natural Science Foundation of China(No.82270545 and No.81870381);Natural Science Foundation of Hebei Province(No.H2014206446)。
Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium ...
关键词：tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease MYOFIBROBLASTS transforming growth factor-β1 
Gut microbiota controls the development of chronic pancreatitis:A critical role of short-chain fatty acids-producing Gram-positive bacteria被引量：7
《Acta Pharmaceutica Sinica B》2023年第10期4202-4216,共15页Li-Long Pan Zheng-Nan Ren Jun Yang Bin-Bin Li Yi-Wen Huang Dong-Xiao Song Xuan Li Jia-Jia Xu Madhav Bhatia Duo-Wu Zou Chun-Hua Zhou Jia Sun 
supported by funds from the National Natural Science Foundation of China(Grant Nos.82070666,82122068);the Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province(Grant No.BK20200026,China);the Collaborative Innovation Center of Food Safety and Quality Control of Jiangsu Province,the Fundamental Research Funds for the Central Universities(Grant Nos.JUSRP221037,JUSRP22007,China);the China Postdoctoral Science Foundation(Grant No.2022M721366);the Excellent Postdoctoral Program of Jiangsu Province(Grant No.2023ZB168,China);Wuxi City’s first“double hundred”young and middle-aged medical and health talents(Grant No:BJ2020045,China);Wuxi Social Development Science and Technology Demonstration Project(Grant No:N20201003,China)。
Chronic pancreatitis(CP)is a progressive and irreversible fibroinflammatory disorder,accompanied by pancreatic exocrine insufficiency and dysregulated gut microbiota.Recently,accumulating evidence has supported a corr...
关键词：Chronic pancreatitis Antibiotic exposure Gut microbiota Short-chain fatty acids-producing bacteria Pancreatic fibrogenesis Macrophage responses Toll-like receptor 4 
Integrative omics analysis identifies macrophage migration inhibitory factor signaling pathways underlying human hepatic fibrogenesis and fibrosis被引量：1
《Journal of Bio-X Research》2019年第1期16-24,共9页Zhipeng Liu Naga Chalasani Jingmei Lin Samer Gawrieh Yuan He Yan J.Tseng Wanqing Liu 
supported in part by a NIH grant,No.R01 DK106540(to WL).
The genetic basis underlying liver fibrosis remains largely unknown.We conducted a study to identify genetic alleles and underlying pathways associated with hepatic fibrogenesis and fibrosis at the genome-wide level i...
关键词：hepatic fibrosis GENOMICS macrophage migration inhibitory factor alpha-smooth muscle actin pathway enrichment analysis genetic susceptibility 
Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis被引量：2
《Asian Pacific Journal of Tropical Medicine》2017年第5期423-432,共10页Naglaa M.El-Lakkany Walaa H.El-Maadawy Sayed H.Seif el-Din Olfat A.Hammam Salwa H.Mohamed Shahira M.Ezzat Marwa M.Safar Samira Saleh 
supported by Theodore Bilharz Research Institute(grant number:ID-MS-99/A,2012,PI:Naglaa El-Lakkany)
Objective:To investigate the antifibrotic role of rosmarinic acid(RA),a natural polyphenolic compound,on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods:The impact of RA on stellate cell line...
关键词：Hepatic fibrosis Hepatic stellate cells Rosmarinic acid APOPTOSIS PROLIFERATION Profibrogenic markers 
Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects被引量：15
《World Journal of Gastroenterology》2014年第42期15499-15517,共19页S?ren M?ller Jens H Henriksen Flemming Bendtsen 
Supported by Novo Nordisk Foundation and the University of Copenhagen
In addition to complications relating to the liver, patients with cirrhosis and portal hypertension develop extrahepatic functional disturbances of multiple organ systems. This can be considered a multiple organ failu...
关键词：FIBROGENESIS Splanchnic haemodynamics Inflammation Bacterial translocation Infections Systemic circulation Cirrhotic cardiomyopathy Hepatopulmonary syndrome Portopulmonary hypertension Hepatorenal syndrome ASCITES 
Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation被引量：6
《World Journal of Gastroenterology》2014年第36期13088-13104,共17页Devanshi Seth Alastair Duly Paul C Kuo Geoffrey W McCaughan Paul S Haber 
Supported by Philanthropic Anonymous Source;the University of Sydney Bridging Support Grant,in part for Honours Project;Supported by the National Health and Medical Research Council,No.NHMRC Practitioner Research Fellowship for PH support
AIM: To investigate over-expression of Osteopontin (OPN) pathway expression and mechanisms of action in human alcoholic liver disease (ALD), in vivo and in vitro acute alcohol models.
关键词：Hepatic stellate cells Liver cirrhosis PLASMIN STEATOSIS FIBROGENESIS Transforming growth factor β Osteopontin isoform 
Fibrogenesis in alcoholic liver disease被引量：4
《World Journal of Gastroenterology》2014年第25期8048-8054,共7页Hideki Fujii Norifumi Kawada 
Supported by A grant-in-Aid for Scientific Research (B) from the Japan Society for the Promotion of Science (JSPS) through grant No.25293177 to Kawada N (2013-2016);a Grant-in-Aid for Scientific Research (C) from the JSPS through grant No.25461007 to Fujii H(2013-2016)
Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. In developed countries, ALD is a major cause of end-stage liver disease that requires transplantation. The spectrum of ALD includes ...
关键词：Stellate cell Kupffer cell STEATOHEPATITIS FIBROSIS CYTOKINE Oxidative stress 
Cellular and molecular mechanisms in the pathogenesis of liver fibrosis:An update被引量：91
《World Journal of Gastroenterology》2014年第23期7260-7276,共17页Gülsüm ?zlem Elpek 
There have been considerable recent advances towards a better understanding of the complex cellular and molecular network underlying liver fibrogenesis.Recent data indicate that the termination of fibrogenic processes...
关键词：Liver Liver fibrosis CIRRHOSIS FIBROGENESIS Hepatic stellate cells MYOFIBROBLAST Extracellular matrix 
Mechanisms of fibrogenesis in liver cirrhosis:The molecular aspects of epithelial-mesenchymal transition被引量：18
《World Journal of Hepatology》2014年第4期207-216,共10页Sun-Jae Lee Kyung-Hyun Kim Kwan-Kyu Park 
Supported by The National Research Foundation of Korea Grant funded by the Korean Government,No.2012R1A1A401015639
Liver injuries are repaired by fibrosis and regeneration.The cause of fibrosis and diminished regeneration,especially in liver cirrhosis,is still unknown.Epithelialmesenchymal transition(EMT) has been found to be asso...
关键词：Epithelial-mesenchymal transition Liver Fibrosis TRANSFORMING growth factor-beta1 Biological markers 
PNPLA3 I148M polymorphism and progressive liver disease被引量：19
《World Journal of Gastroenterology》2013年第41期6969-6978,共10页Paola Dongiovanni Benedetta Donati Roberta Fares Rosa Lombardi Rosellina Margherita Mancina Stefano Romeo Luca Valenti 
Supported by Associazione Malattie Metaboliche del Fegato ONLUS(Non-profit organization for the Study and Care of Metabolic Liver Diseases);Centro Studi Malattie Metaboliche del Fegato,Universitàdegli Studi di Milano
The 148 Isoleucine to Methionine protein variant(I148M)of patatin-like phospholipase domain-containing 3(PNPLA3),a protein is expressed in the liver and is involved in lipid metabolism,has recently been identified as ...
关键词：Alcoholic LIVER DISEASE Chronic HEPATITIS C virus HEPATITIS FIBROGENESIS Genetics Hepatocellular carcinoma LIVER DISEASE Nonalcoholic fatty LIVER DISEASE Patatin-like PHOSPHOLIPASE domain-containing 3 Single nucleotide POLYMORPHISM Steatosis 
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